X Mab 500 Mg Injection 50 Ml

X Mab 500 Injection 50ml

Rpg Life Sciences Ltd.

Vial of 50 ML

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MRP ~~₹42658.5~~

₹34979.97

₹853.17/ML

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Prescription required for this medicine

Store in refrigerator or (2^o - 8^o C) Do Not Freeze

Composition

Polysorbate (35 Mg) + Rituximab (500 Mg) + Sodium Chloride (450 Mg) + Trisodium Citrate (367.5 Mg)

X Mab 500 Injection 50ml is primarily used to manage various types of blood cancers. It belongs to a class of medicines known as monoclonal antibodies.

This medicine is employed in the management of blood cancers, rheumatoid arthritis, and certain autoimmune disorders. In these conditions, it helps control inflammation and reduce symptoms, offering relief to the patients.

Before starting this medicine, it's vital to consult your doctor, who will guide you on the appropriate dosage and frequency. Ensure you inform your doctor about any pre-existing diseases or ongoing medications. If you experience any side effects while on this medicine, inform your doctor immediately. For the best results, continue the medicine for the duration prescribed by your doctor.

X Mab 500 Injection 50ml is beneficial for managing the following health conditions:

Management of Non-Hodgkin lymphoma, a cancer that affects the lymphatic system
Control of Chronic lymphocytic leukaemia, a blood and bone marrow cancer
Reduction of inflammation, pain, and joint damage in Rheumatoid arthritis
Management of Granulomatosis with polyangiitis and microscopic polyangiitis, rare disorders that cause inflammation of blood vessels

Directions for Use of X Mab 500 Injection 50ml

Administer X Mab 500 Injection 50ml as follows:

Ensure you are taking the proper dosage.
Only a certified professional should administer the injection.
Adhere to the dietary recommendations given by your doctor.

X Mab 500 Injection 50ml is administered intravenously.

Side Effects of X Mab 500 Injection 50ml

X Mab 500 Injection 50ml may have the following common side effects:

Infusion reactions: This might include symptoms like fever, chills, shivering or shaking, low blood pressure, and skin rashes (hives).
Infections: You might encounter various bacterial, viral, or fungal infections.
Neutropaenia: This refers to a lower count of neutrophils, a type of white blood cell that fights infection.
Anaemia: This means your body has fewer red blood cells than normal.
Thrombocytopaenia: This condition involves having fewer platelets in your blood than normal. Platelets help with clotting to prevent excessive bleeding.

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing the use of X Mab 500 Injection 50ml. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are some general guidelines for managing common side effects:

Infusion reactions: If you experience reactions during or after the infusion of X Mab 500 Injection 50ml, inform your doctor right away. They may slow down the rate of your infusion to help manage these symptoms.
Infections: If you notice signs of an infection, such as fever, chills, or increased tiredness after using X Mab 500 Injection 50ml, it is important to inform your doctor immediately. They can check for infections and prescribe appropriate medications if necessary.

X Mab 500 Injection 50ml contains Rituximab (500 mg) and works in the following ways:

Binds to CD20 antigen: Rituximab specifically targets and binds to the CD20 antigen present on the surface of B-lymphocytes.
Depletes B-cells: Once bound to CD20, Rituximab triggers processes that lead to the reduction of B-cells. These processes include antibody-dependent cellular cytotoxicity, complement-dependent cytotoxicity, and apoptosis.
Manages medical conditions: The depletion of B-cells assists in managing the conditions for which X Mab 500 Injection 50ml is prescribed, including blood cancers, rheumatoid arthritis, and certain autoimmune disorders.

Pregnancy

Caution is advised while taking X Mab 500 Injection 50ml if you are pregnant. It is best to consult your doctor before taking this medicine.

Breastfeeding

X Mab 500 Injection 50ml is contraindicated for breastfeeding/lactating women. Discuss this with your doctor to understand the potential risks and benefits.

Alcohol

It's always wise to consult your doctor for advice on this matter.

Liver

Caution is advised when using X Mab 500 Injection 50ml if you have a history of liver problems. It's paramount to discuss this with your doctor before starting the medication, as it may affect liver function.

Kidney

If you have a history of kidney problems, caution is advised while taking X Mab 500 Injection 50ml. Always consult your doctor before initiating this medicine.

Using Machines & Driving

There are no known risks associated with using machinery or driving while on X Mab 500 Injection 50ml, but it's always best to discuss any concerns with your doctor.

Allergy

It is contraindicated if you have a known hypersensitivity to rituximab or any of the components in X Mab 500 Injection 50ml. Ensure that you inform your doctor about any allergies before beginning this medication.

Children

Caution is advised while administering X Mab 500 Injection 50ml to children under 18 years of age. Always consult your doctor before giving this medicine to a child.

Older Patients

Older patients should take X Mab 500 Injection 50ml under medical supervision as they may be more susceptible to its side effects. Caution is advised if patients are above 70 years of age, as they might also have liver and kidney issues. Your doctor will guide you based on your health status.

Interactions of X Mab 500 Injection 50ml

Drug-Drug Interactions

X Mab 500 Injection 50ml interacts with the following medicines:

Immunosuppressants: Immunosuppressant medicines like methotrexate or azathioprine can increase the risk of infections when taken with rituximab due to enhanced immune suppression.
Antihypertensive Agents: Antihypertensive medications like enalapril can lead to severe hypotension during rituximab infusion due to their combined blood pressure-lowering effects.
Biologic Therapies: Other biologic therapies, such as adalimumab or infliximab, can increase the risk of serious infections and adverse immune responses when used with rituximab.

Drug-Food Interactions

There are no food interactions with X Mab 500 Injection 50ml.

Drug-Disease Interactions

X Mab 500 Injection 50ml interacts with the following diseases:

Active Infections: If you have an active infection, using X Mab 500 Injection 50ml might worsen your condition as it can lower your body's ability to fight infections.
History of Recurrent or Chronic Infections: If you have a history of recurrent or chronic infections, use this medicine with caution, as it can potentially increase the risk of infections.
Underlying Immunodeficiency: This medicine's use in patients with underlying immunodeficiency could lead to severe infections due to a further weakened immune system.
Heart Disease or Cardiovascular Problems: If you have a history of heart disease or cardiovascular problems, be cautious while using this medicine, as it might exacerbate these conditions.

Daily Dose

The daily dose of X Mab 500 Injection 50ml should be administered as prescribed by your doctor. The dosage may vary based on the severity of your condition and how you respond to the medication. It's crucial to adhere to the prescribed dosage and not exceed it without consulting your doctor.

Over Dose

An overdose is highly unlikely for this medication as it is administered by a skilled healthcare professional.

Missed Dose

If you forget to take your X Mab 500 Injection 50ml as scheduled, consult your doctor for advice.

Keep X Mab 500 Injection 50ml vials ideally between 2°C to 8°C.
Protect the vials from direct light.
Dispose of any partially used vials.
Always keep this medicine out of children's reach.
Ensure you use the injection before the expiry date mentioned on the packaging.

For those managing blood cancers, consider a diet rich in antioxidants, such as fruits, vegetables, and whole grains, to support overall health.
If you're dealing with rheumatoid arthritis, try to engage in low-impact exercises like swimming or cycling, which can help in reducing joint pain and stiffness. Always consult your doctor before starting any exercise regimen.

Fact Box

Drug Category	Monoclonal Antibody
Therapeutic Category	Oncolytic/Antirheumatic
Available Dosage Types	Injection
Habit Forming	No
Ailment	Leukaemia, Rheumatoid Arthritis

What disorders does X Mab 500 Injection 50ml help manage?

X Mab 500 Injection 50ml is used to manage blood cancers, rheumatoid arthritis, and certain autoimmune disorders.

How does X Mab 500 Injection 50ml work?

X Mab 500 Injection 50ml contains rituximab that targets specific proteins in B-cells, helping to control the relevant disorder.

Can X Mab 500 Injection 50ml be used with other medicines?

Yes, X Mab 500 Injection 50ml may be combined with other medications, depending on your medical condition and doctor's advice.

What are the side effects of X Mab 500 Injection 50ml?

Common side effects include infusion reactions, infections, low blood count, headache, fatigue, and muscle or joint pain.

How can I manage these side effects?

Side effect management may involve premedication to reduce the risk of infusion reactions and regular monitoring of blood counts.

Can I receive vaccinations while using X Mab 500 Injection 50ml?

Live vaccines should be avoided during and after using X Mab 500 Injection 50ml due to the increased risk of vaccine-related adverse events.

How is X Mab 500 Injection 50ml administered?

X Mab 500 Injection 50ml is administered intravenously by a doctor in a clinical setting.

Certified Content

Written by

Dr Nikita Lobo

Medical Editor & Reviewer | 7 years

BDS, MDS

Reviewed by

Dr. Chhavi Rosha

Health & Medical Content Writer | 8 years

BMS, FMC, MD Resident

Check out Editorial Policy

Manufacturer details

RPG House, 463, Dr. Annie Besant Road, Worli, Mumbai 400030

Country of origin: INDIA

References

Genentech. (2010). Rituxan prescribing information. https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/103705s5311lbl.pdf
Genentech. (1997). HIGHLIGHTS OF PRESCRIBING INFORMATION [Prescribing information]. https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/103705s5464lbl.pdf
Sarsour, K., Beckley‐Kartey, S., Melega, S., Odueyungbo, A., Kirchner, P., Khalife, N., & Bangs, J. (2020). Rituximab utilization for approved and off‐label nononcology indications and patients’ experiences with the Patient Alert Card. Pharmacology Research & Perspectives, 8(1). https://doi.org/10.1002/prp2.555
Hanif, N., & Anwer, F. (2024, February 28). Rituximab. StatPearls - NCBI Bookshelf. https://www.ncbi.nlm.nih.gov/books/NBK564374/
Rituximab: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB00073

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