Vosicaz Tablet 10

Glenmark Pharmaceuticals Ltd.

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Composition

Voriconazole (200 Mg)

Vosicaz Tablet 10 is used to manage serious fungal infections in adults. It belongs to a class of medicines known as azoles.

In addition to treating severe fungal infections, Vosicaz Tablet 10 is effective against invasive aspergillosis, candidemia in non-neutropenic patients, and disseminated Candida infections affecting various body parts, such as the skin, abdomen, kidneys, bladder wall, and wounds. It also addresses oesophagal candidiasis and serious infections caused by Scedosporium apiospermum and Fusarium species. Furthermore, it can prevent fungal infections in high-risk bone marrow transplant recipients.

Take this medicine exactly as directed by your doctor. Before starting, inform your doctor of any existing health conditions or medications you are taking. If you experience any side effects, contact your doctor immediately. For optimal results, it is crucial to continue the medication for the full duration prescribed by your doctor.

Vosicaz Tablet 10 is used for the following:

Managing invasive aspergillosis (a serious infection caused by a type of fungus called Aspergillus)
Dealing with candidemia in non-neutropenic patients
Handling disseminated Candida infections in various body parts, including skin, abdomen, kidney, bladder wall, and wounds
Tackling oesophagal candidiasis (a yeast infection in the food pipe)
Controlling serious fungal infections caused by Scedosporium apiospermum and Fusarium species
Preventing fungal infections in high-risk bone marrow transplant recipients

To use Vosicaz Tablet 10 correctly, follow these instructions:

Swallow the tablet whole with water.
Do not crush or chew it.
Always consult your doctor if you have any doubts about how to take this medicine.

Vosicaz Tablet 10 is taken orally.

Here are some common side effects you might experience while taking Vosicaz Tablet 10:

Abdominal pain
Fever
Rash
Nausea and vomiting
Diarrhoea
Headache
Swelling in your hands, ankles, or feet
Blurred vision
Difficulty breathing or wheezing

Managing the Side Effects:

Most side effects are temporary and generally harmless, and they resolve when you discontinue using Vosicaz Tablet 10. However, if you experience serious side effects or worsening symptoms, please consult your doctor.

Here are some tips for managing common side effects:

Nausea and vomiting: Try taking Vosicaz Tablet 10 with a meal to help reduce these symptoms.
Diarrhoea: Consider taking this medicine with food or milk to lessen this effect.

Vosicaz Tablet 10 contains voriconazole (200 mg), which works on your body in the following way:

Inhibits ergosterol synthesis: Voriconazole blocks the production of ergosterol, a vital component of the fungal cell membrane. By inhibiting its synthesis, voriconazole disrupts the structure of these membranes.
Prevents fungal growth: Disrupting the fungal cell membrane prevents the growth and spread of fungi, effectively managing the infection.

Pregnancy

Vosicaz Tablet 10 is not generally recommended during pregnancy. If you are pregnant or planning to conceive, consult your doctor before taking this medicine.

Breastfeeding

Caution is advised while taking Vosicaz Tablet 10 during breastfeeding, so consult your doctor before use.

Alcohol

Caution is advised while taking Vosicaz Tablet 10 with alcohol, so consult your doctor before use.

Liver

If you have liver disease, you should use Vosicaz Tablet 10 with caution, as dose adjustments may be needed. Discuss your liver condition with your doctor before starting this medicine.

Kidney

If you have any kidney health issues, consult your doctor before taking Vosicaz Tablet 10.

Using Machines & Driving

Vosicaz Tablet 10 may cause visual disturbances such as blurred vision and colour vision changes, so caution is advised while operating machinery and driving.

Allergy

Vosicaz Tablet 10 should not be taken if you are allergic to voriconazole or any of the tablet's ingredients. Consult your doctor if you have known allergies.

Children

Vosicaz Tablet 10 is not recommended for children under 2 years of age. Caution is advised when giving this medicine to children above 2 years of age, or give it only when prescribed by the doctor or paediatrician.

Older Patients

Older patients should take Vosicaz Tablet 10 under medical supervision owing to potential susceptibility to side effects, particularly liver and kidney issues. Your doctor will guide you based on your health status.

Drug-Drug Interactions

Vosicaz Tablet 10 interacts with the following medicines:

Antiretroviral medications: Medicines like efavirenz and ritonavir can decrease the effectiveness of Vosicaz Tablet 10.
Antituberculotics: Rifampin, when taken with Vosicaz Tablet 10, may reduce the blood levels of voriconazole, potentially decreasing its efficacy.
Antiepileptics: Medicines such as carbamazepine can increase the metabolism of voriconazole, lessening its effect.
Immunosuppressants: Sirolimus and similar medicines have an increased risk of side effects when used alongside Vosicaz Tablet 10.
Ergot alkaloids: The simultaneous use of medications such as ergotamine and dihydroergotamine with Vosicaz Tablet 10 could potentially increase the risk of ergotism (a condition causing severe pain in limbs).
Antiarrhythmics: Use of quinidine in combination with Vosicaz Tablet 10 may lead to increased levels of quinidine, which can cause serious heart problems.

Drug-Food Interactions

There are no known food interactions with Vosicaz Tablet 10.

Drug-Disease Interactions

Vosicaz Tablet 10 interacts with the following diseases:

Liver disease: This medicine may cause liver enzymes to rise; regular monitoring is recommended for patients with liver disease.
Heart disease: Patients suffering from heart conditions need to take caution as Vosicaz Tablet 10 may prolong the QT interval, leading to serious heart rhythm disorders.

Daily Dose

The daily dose of Vosicaz Tablet 10 should be taken as instructed by your doctor. The dosage might vary depending on the severity of your condition and how you respond to the medication. Follow your doctor's instructions and avoid exceeding the suggested dosage without consulting your doctor.

Over Dose

If you take more than the prescribed dose of Vosicaz Tablet 10, you might experience an increase in side effects such as visual disturbances, fever, or nausea. In this case, it's important to inform your doctor right away.

Missed Dose

If you forget to take a dose of Vosicaz Tablet 10, you should take it as soon as you remember. However, if it's close to the time for your next dose, skip the missed one and continue with your regular schedule. Never adjust your dosage without talking to your doctor.

Store Vosicaz Tablet 10 below 30°C in a dry place.
Protect from light.
Always keep it out of reach of children.
Use this medicine before the expiry date mentioned on the package.

If you take Vosicaz Tablet 10, maintaining a healthy lifestyle can enhance effectiveness. Stay well-hydrated to support your body's natural defence mechanisms.
Adopt a balanced diet rich in fruits and vegetables to boost your immune system and help fight off fungal infections.

Fact Box

Drug Category	Ergosterol Synthesis Inhibitor
Therapeutic Category	Antifungal
Available Dosage Types	Tablet
Habit Forming	No
Ailment	Invasive Aspergillosis, Candidemia, Esophageal Candidiasis

What is Vosicaz Tablet 10 used for?

Vosicaz Tablet 10 is used to manage serious fungal infections, including invasive aspergillosis and candidemia in adults.

Can I take Vosicaz Tablet 10 with food?

It is best to follow your doctor’s instructions regarding whether to take it on an empty stomach or with food. Your doctor will provide specific guidance based on your condition and other medications you may be taking.

How long does Vosicaz Tablet 10 take to work?

The duration varies depending on the type and severity of the fungal infection. Always continue taking the medication as prescribed.

What if I miss a dose of Vosicaz Tablet 10?

Take the missed dose as soon as you remember. If it's nearly time for the next one, skip the missed dose and continue your regular schedule.

Can I use Vosicaz Tablet 10 during pregnancy?

This medicine is not recommended during pregnancy unless necessary. Always consult your doctor before use.

Are there any side effects of taking Vosicaz Tablet 10?

Common side effects include visual disturbances, fever, rash, nausea, vomiting, diarrhoea, headache, swelling in your limbs, abdominal pain, and respiratory disorders. If they persist or worsen, consult your doctor.

Does Vosicaz Tablet 10 interact with other medicines?

Yes, it can interact with several medicines, including efavirenz, rifampin, and carbamazepine. Always inform your doctor about all medicines you're currently taking.

Certified Content

Written by

Dr. Michelle Frank

Medical Content Writer | 8 years

Doctor of Medicine

Reviewed by

Dr. Divya Chauhan

Medical Writer & Reviewer | 6 years

BAMS, APG, PG

Check out Editorial Policy

Manufacturer details

Glenmark House, HDO-Corporate Building, Wing-A, B.D. Sawant Marg, Chakala Off. Western Express Highway, Andheri (East), Mumbai, Maharashtra, 400099 India

Country of origin: INDIA

References

Voriconazole: Uses, Interactions, Mechanism of action https://go.drugbank.com/drugs/DB00582
Voriconazole: MedlinePlus drug information. (n.d.). MedlinePlus - Health Information from the National Library of Medicine. https://medlineplus.gov/druginfo/meds/a605022.html
U.S. Food and Drug Administration. (2006). Voriconazole. https://www.accessdata.fda.gov/drugsatfda_docs/label/2006/021266s18,021267s19,021630s10lbl.pdf
Voriconazole - LiverTox - NCBI bookshelf. (2017, May 17). National Center for Biotechnology Information. https://www.ncbi.nlm.nih.gov/books/NBK547891/
National Center for Biotechnology Information (2024). PubChem Compound Summary for CID 71616, Voriconazole. https://pubchem.ncbi.nlm.nih.gov/compound/Voriconazole.

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