Vorizol 200 Mg Injection 2 Ml

Vorizol Injection 1

Natco Pharma Ltd

Vial of 1 UNITS

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Composition

Voriconazole (200 Mg)

Vorizol Injection 1 is primarily used to manage serious fungal infections in adults and children over the age of 2 years. This medicine belongs to the category of antifungals, specifically the triazole class.

This injection is also beneficial in managing severe systemic fungal infections like invasive aspergillosis, candidaemia in non-neutropenic patients, oesophagal candidiasis, and grave infections caused by Scedosporium apiospermum and Fusarium species. The injection form of this medicine is particularly effective in addressing these critical conditions in hospitalised or immunocompromised patients.

Before taking this injection, it's crucial to inform your doctor about any pre-existing conditions or ongoing medications. While using this medicine, if you experience any side effects, immediately notify your doctor. For best results, continue administering the medicine for the duration prescribed by your doctor.

Vorizol Injection 1 is used for managing various serious fungal infections, such as:

Systemic aspergillosis, a severe infection that affects the lungs and can spread to other organs.
Candidaemia, a condition that involves a type of yeast called Candida entering the bloodstream in non-neutropenic patients.
Oesophageal candidiasis, a yeast infection that occurs in the tube connecting your mouth and stomach, known as the oesophagus.
Infections caused by Scedosporium apiospermum and Fusarium species, types of fungi that can cause serious infections in humans.

Directions for Use of Vorizol Injection 1

The injection needs to be administered intravenously, which means it is injected into a vein by a trained healthcare professional.
Make sure this process is carried out under medical supervision.
The injection should be given slowly over 1 to 2 hours.
Do not try to self-administer this medicine at home. Always consult your doctor for specific advice.

Vorizol Injection 1 is administered intravenously.

Vorizol Injection 1 may have the following common side effects:

Visual disturbances: This can include blurred vision or changes in colour perception.
Fever
Nausea and vomiting
Headache
Rash: This refers to changes in skin colour or texture, which can be itchy or painful.
Liver function test abnormalities: This suggests your liver may not be working as well as it should.
Hallucinations: You might see, hear, feel, or smell something that doesn't exist.

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve upon discontinuing the use of Vorizol Injection 1. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are some general guidelines for managing common side effects:

Nausea and vomiting: Try taking easily digestible and bland meals while on the course of this medication to lessen this effect.
Fever: Consult with your doctor immediately in case you develop a fever.

Vorizol Injection 1 contains voriconazole (200 mg). Here's how it works:

Inhibition of Cytochrome P450-Mediated 14α-Lanosterol Demethylation: Voriconazole stops a specific enzyme process in fungi termed 14α-lanosterol demethylation. This process forms a key part of ergosterol biosynthesis, a vital component for fungal cell membranes.
Disrupts Fungal Cell Membrane: By blocking this particular enzyme process, voriconazole disrupts the cell membrane of the fungus, thereby reducing its growth and activity. This action makes voriconazole a potent antifungal agent against a wide range of clinically significant fungal pathogens.

Pregnancy

Vorizol Injection 1 may harm the unborn baby. If you are pregnant or planning to get pregnant, it is best to discuss this with your doctor before starting this medicine.

Breastfeeding

Voriconazole, the active ingredient in Vorizol Injection 1, is excreted in breast milk. Therefore, breastfeeding is not recommended during treatment with this medicine.

Alcohol

It's always wise to consult your doctor about consuming alcohol while taking this medicine.

Liver

If you have liver problems, extra care is needed when using Vorizol Injection 1 as it may affect liver function. Your doctor will recommend suitable dosage adjustments or alternatives if necessary.

Kidney

Although no dose adjustment is required for those with kidney problems, caution should be exercised when using Vorizol Injection 1. Always discuss any kidney health issues with your doctor.

Using Machines & Driving

This medicine can cause visual disturbances, which might affect your ability to drive or operate machinery. Be cautious and consult your doctor if you experience any such side effects.

Allergy

If you're allergic to voriconazole or any other ingredients in Vorizol Injection 1, do not use this medicine. Make sure to inform your doctor about all known allergies before starting the medication.

Children

Vorizol Injection 1 can be used in children aged 2 years and above under a doctor's guidance. Always consult your doctor before giving this medicine to a child.

Older Patients

Older patients should use Vorizol Injection 1 under medical supervision as they may be more susceptible to its side effects and could have existing liver or kidney conditions. Your doctor will guide you based on your health status.

Drug-Drug Interactions

Vorizol Injection 1 interacts with the following medicines:

Anticoagulants: When administered with anticoagulants like warfarin, the levels of these medicines might increase in your body, potentially leading to a higher risk of bleeding.
Immunosuppressants: The medicine can interact with immunosuppressants such as cyclosporine and tacrolimus, increasing their levels in your body.
Epilepsy Medicines: If you take epilepsy medicines like phenytoin, using this injection can increase their level in your blood.
Benzodiazepines: Mixing this medicine with diazepam can lead to a higher level of these sedatives in your body.

Drug-Food Interactions

Consuming grapefruit juice while on this medication might increase the level of voriconazole in your body.

Drug-Disease Interactions

Vorizol Injection 1 interacts with the following diseases:

Liver Disease: If you have liver disease, this medicine might affect your condition by increasing medication levels due to reduced metabolism.
Heart Conditions: Patients with heart conditions should be cautious as this medicine could potentially prolong the QT interval and cause cardiac arrhythmias.

Daily Dose

Your doctor will prescribe the daily dose of Vorizol Injection 1 based on your health condition and how you respond to the medication. It's crucial to stick to the prescribed dosage and avoid exceeding it without your doctor's advice. For more specific information, refer to the package insert.

Over Dose

The possibility of an overdose of Vorizol Injection 1 is rare as it is administered by a trained healthcare professional.

Missed Dose

If you forget to get your regular dose of Vorizol Injection 1, get in touch with your doctor immediately.

Store Vorizol Injection 1 at a standard room temperature.
Avoid exposure to direct sunlight or extreme heat.
Keep it in a place where children cannot reach it.
Make sure you use the medicine before its expiration date.

As Vorizol Injection 1 is used to manage severe fungal infections, maintaining a clean and hygienic environment can help prevent these infections. Regular cleaning of your surroundings can be beneficial.
Eating a balanced diet rich in vitamins and minerals can boost your immunity, making you less susceptible to such fungal infections. Include plenty of fresh fruits, vegetables, lean proteins, and whole grains in your meals.

Fact Box

Drug Category	Fungal Cytochrome P450 Inhibitor
Therapeutic Category	Antifungal
Available Dosage Types	Injection
Habit Forming	No
Ailment	Invasive Aspergillosis, Candidaemia, Oesophageal Candidiasis

What is Vorizol Injection 1 used for?

Vorizol Injection 1 is used to manage severe systemic fungal infections in adults, such as invasive aspergillosis and candidaemia.

How does Vorizol Injection 1 work?

The active ingredient, voriconazole, interrupts the making of a substance in the fungal cell membrane, thus controlling the infection effectively.

Can I take Vorizol Injection 1 if I'm allergic to any of its ingredients?

No, you should not use Vorizol Injection 1 if you're allergic to voriconazole or any other ingredients in it. Consult your doctor for advice.

Are there any side effects of Vorizol Injection 1?

Yes, common side effects include visual disturbances, fever, nausea, vomiting, headache, rash, and liver function test abnormalities.

Are there any precautions while using Vorizol Injection 1?

Yes, it's important to monitor your liver function and alert your doctor if you experience vision changes or serious skin reactions.

Can I use Vorizol Injection 1 while pregnant or breastfeeding?

Vorizol Injection 1 may harm the foetus. Avoid use during pregnancy and breastfeeding unless advised by your doctor.

How should I store my Vorizol Injection 1?

Store your medicine at room temperature, away from light.

Certified Content

Written by

Dr Nikita Lobo

Medical Editor & Reviewer | 7 years

BDS, MDS

Reviewed by

Dr. Chhavi Rosha

Health & Medical Content Writer | 8 years

BMS, FMC, MD Resident

Check out Editorial Policy

Manufacturer details

Natco House Road No.2, Banjara Hills Hyderabad-500 034, India

Country of origin: INDIA

References

VFEND® Tablets (voriconazole).(N.d.). Fda.Gov. Retrieved August 20, 2024, from
https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/021266s032lbl.pdf
VORICONAZOLE for injection. (N.d.). Fda.Gov. Retrieved August 20, 2024, from https://www.accessdata.fda.gov/drugsatfda_docs/label/2022/208562s006lbl.pdf
voriconazole.(N.d.). Pfizer.Com. Retrieved August 20, 2024, from https://labeling.pfizer.com/ShowLabeling.aspx?id=12292
VFEND 50 mg film-coated tablets. (N.d.). Europa.Eu. Retrieved August 20, 2024, from https://www.ema.europa.eu/en/documents/product-information/vfend-epar-product-information_en.pdf
Voriconazole: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB00582

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We, at Truemeds make a diligent attempt to deliver accurate, expert- drafted and thoroughly reviewed medicine related information to our consumers. However, it should, by no means, be considered a substitute for prescription from a certified doctor or a trustworthy doctor-patient relationship. In fact we detest any form of self medication without expert advice. The sole purpose of the information on our portal is to educate our consumers, which helps improve the communication between a doctor and a patient. The information by no means is complete in its entirety and should not be used to diagnose or treat any medical condition. No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately.

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