Valentas 100 Mg Tablet 10

Valentas 100 Tablet 10

Lupin Ltd

Strip of 10 Units

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Composition

Sacubitril (49 Mg) + Valsartan (51 Mg)

Valentas 100 Tablet is a prescribed medicine primarily used for managing certain types of heart failure. This combination medication belongs to the class of medicines that are neprilysin inhibitors and angiotensin II receptor blockers.

The tablet also plays a significant role in reducing the strain on a failing heart. It enhances the heart's efficiency in pumping blood. Large-scale clinical studies have indicated the effectiveness of this medicine in decreasing the risk of cardiovascular death and hospitalisation due to heart failure.

It's essential to take this medicine as directed by your doctor. Before initiating this medication, make sure to inform your doctor about any existing health conditions or current treatments. If you experience any side effects, notify your doctor promptly. For optimal results, continue taking this medicine for the entire duration prescribed by your doctor.

Valentas 100 Tablet is used for the following:

Management of heart failure in adults classified as NYHA class II-IV
Reduction of the risk of cardiovascular death in adults with reduced ejection fraction
Decrease in the rate of hospitalisation for patients with heart failure

Directions for Use of Valentas 100 Tablet 10

Here are some instructions you should follow while taking Valentas 100 Tablet:

Follow the dosage and timing instructions provided by your doctor precisely.
Do not change or exceed the prescribed dose without consulting your doctor.
Consult your doctor before discontinuing the medication; do not stop taking it without their guidance.
Adhere to the dietary recommendations given by your doctor.

Valentas 100 Tablet is taken orally.

Valentas 100 Tablet may have the following common side effects:

Hypotension: This term refers to low blood pressure which could make you feel faint or dizzy.
Hyperkalaemia: This is a condition where the level of potassium in your blood is higher than normal, which can affect your heart rhythm.
Cough
Dizziness
Renal impairment: This is a medical term for kidney problems, which could lead to difficulties in the kidneys' ability to filter waste products from your blood.

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve upon discontinuing the use of Valentas 100 Tablet. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are some general guidelines for managing common side effects:

Hypotension: If you feel dizzy or faint after taking Valentas 100 Tablet, seek medical attention.
Cough: Gurgling with warm water can help you with this side effect.

Valentas 100 Tablet contains two key components:

Sacubitril (49 mg): Sacubitril is a neprilysin inhibitor. Its primary function is to block the enzyme neprilysin, which is responsible for breaking down natriuretic peptides. By inhibiting neprilysin, sacubitril increases these peptide levels which help relax blood vessels, enhance sodium and water excretion, and decrease cardiac stress.
Valsartan (51 mg): As an angiotensin II receptor blocker or ARB, valsartan blocks the action of angiotensin II. This hormone usually narrows blood vessels and increases blood pressure and cardiac stress.

By working together, sacubitril and valsartan reduce the load on a failing heart, enabling it to pump blood more efficiently.

Pregnancy

Valentas 100 Tablet can cause harm to an unborn baby. Therefore, it is strongly advised that if you are pregnant or planning to conceive, discuss this with your doctor before starting this medicine.

Breastfeeding

It's best to consult your doctor before taking this medicine while nursing.

Alcohol

There is no interaction between alcohol and Valentas 100 Tablet. However, it is always a good idea to consult your doctor for advice tailored to your personal health circumstances.

Liver

If you have liver health issues, caution is advised while taking Valentas 100 Tablet. Discuss any liver-related concerns with your doctor before starting this medicine.

Kidney

For those with kidney problems, careful consideration should be given before taking Valentas 100 Tablet. It is wise to consult your doctor about any existing kidney conditions before taking this medication.

Using Machines & Driving

Valentas 100 Tablet may cause side effects which could affect your ability to drive or operate machinery. Ensure you know how you react to the medication before undertaking such tasks.

Allergy

If you have a history of allergies or hypersensitivity to any component of Valentas 100 Tablet, it is imperative that you discuss this with your doctor prior to taking this medication.

Children

Caution is advised while giving this medicine to children under 18 years of age. Always consult your doctor before giving any medicine to a child.

Older Patients

Older patients should take Valentas 100 Tablet under medical supervision as they may be more susceptible to its side effects. If you are above 70 years of age, discuss with your doctor who will guide you based on your health status.

Drug-Drug Interactions

Valentas 100 Tablet interacts with the following medicines:

ACE inhibitors: Medicines like enalapril and lisinopril can interact with Valentas 100 Tablet, potentially leading to high potassium levels in your blood (hyperkalaemia).
Potassium-sparing diuretics: Medicines such as spironolactone and amiloride may lead to increased potassium levels when taken with Valentas 100 Tablet.
NSAIDs: Medicines like ibuprofen and naproxen can increase the risk of renal impairment when used with Valentas 100 Tablet.
Lithium: Concurrent use of lithium with Valentas 100 Tablet may increase the risk of lithium toxicity.

Drug-Food Interactions

There are no specific interactions between Valentas 100 Tablet and any food or beverage.

Drug-Disease Interactions

Valentas 100 Tablet interacts with the following diseases:

Hypersensitivity: Patients with a history of hypersensitivity or angioedema related to previous ACE inhibitor or ARB therapy may have an increased risk of experiencing similar reactions with Valentas 100 Tablet.
Renal Impairment: Patients with severe renal impairment should use Valentas 100 Tablet cautiously due to the risk of worsening kidney function.
Diabetes: Diabetic patients using aliskiren alongside Valentas 100 Tablet may experience elevated potassium levels.

Daily Dose

The daily dose of Valentas 100 Tablet should be taken as prescribed by your doctor. The dosage may vary based on individual factors such as the severity of your condition and your response to the medicine. Always follow the prescribed dosage and do not exceed it without consulting your doctor.

Over Dose

Overdosing on Valentas 100 Tablet may lead to symptoms such as low blood pressure, high levels of potassium in the blood, and kidney impairment. If you experience these symptoms, inform your doctor.

Missed Dose

If you forgot to take your Valentas 100 Tablet, take it as soon as you remember. However, if it's almost time for your next dose, skip the missed one and continue with your regular dosage schedule. Never adjust your dosage without consulting your doctor.

Store your Valentas 100 Tablet at room temperature, ideally below 30°C.
Keep it in the original packaging to protect it from moisture.
Place it somewhere out of reach of children.
Check the expiry date before use and do not consume it past this date.

For managing heart conditions, reduce your intake of salt. Excessive salt can raise blood pressure, putting extra strain on your heart.
Regular gentle exercise, such as walking or cycling, can help improve the efficiency of your heart. But, always consult your doctor before starting any new exercise regimen.

Fact Box

Drug Category	Neprilysin Inhibitor, ARB
Therapeutic Category	Antihypertensive
Available Dosage Types	Tablet
Habit Forming	No
Ailment	Heart Failure, Reduced Ejection Fraction

What is Valentas 100 Tablet used for?

Valentas 100 Tablet is a prescription medicine used to manage certain types of heart failure, reducing cardiovascular death risk and hospitalisation.

How does Valentas 100 Tablet work?

It contains sacubitril and valsartan that work together to reduce strain on the heart, helping it pump blood more efficiently.

How should I take Valentas 100 Tablet?

You must take the medicine exactly as prescribed by your doctor.

Can pregnant women take Valentas 100 Tablet?

No, the use of Valentas 100 Tablet can cause harm to the foetus. If you discover you're pregnant while taking it, discontinue its use immediately.

What are the potential side effects of Valentas 100 Tablet?

Common side effects include low blood pressure, high blood potassium, cough, dizziness and renal impairment. Consult your doctor if these persist.

Can I take other medications with Valentas 100 Tablet?

Some medicines may interact with Valentas 100. It's important to inform your doctor about all medications you're currently taking before starting on Valentas 100 Tablet.

How should I store Valentas 100 Tablet?

Store the tablets at room temperature, in their original package to protect them from moisture.

Certified Content

Written by

Dr Nikita Lobo

Medical Editor & Reviewer | 7 years

BDS, MDS

Reviewed by

Dr. Chhavi Rosha

Health & Medical Content Writer | 8 years

BMS, FMC, MD Resident

Check out Editorial Policy

Manufacturer details

Kalpataru Inspire, 3rd Floor, Off. Western Express Highway, Santacruz (East), Mumbai

Country of origin: INDIA

References

Novartis Pharmaceuticals Corporation. (2021). Highlights of prescribing information. https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/207620s018lbl.pdf
Entresto. (n.d.). Entresto Summary of product characteristics. https://www.ema.europa.eu/en/documents/product-information/entresto-epar-product-information_en.pdf
CARMADA. (n.d.). Sacubitril and Valsartan tablets [Report]. https://www.sanofi.in/dam/jcr:2e79c610-7644-4d4c-bf51-1651a1804410/Carmada%20PI-%20Valsartan+Secubitril-Annotated-Nov%202023.pdf
Sacubitril: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB09292
Valsartan: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB00177
Kido, K., Colvin, B. M., Szymanski, T. W., & Guglin, M. (2022). Sacubitril/Valsartan Off-Label uses for heart failure. Journal of Cardiac Failure, 28(7), 1185–1201. https://doi.org/10.1016/j.cardfail.2022.03.348

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