Tolsama 15 Mg Tablet 4

Tolsama 15 Tablet 4

Msn Laboratories Ltd

Strip of 4 Units

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MRP ~~₹623.7~~

₹530.14

₹155.93/Units

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Composition

Tolvaptan (15 Mg)

Strength:

30 MG 15 MG

Tolsama 15 Tablet is primarily used to manage clinically significant hypervolemic and euvolemic hyponatremia, which are conditions characterised by low blood sodium levels. This medicine belongs to a category of medications known as vasopressin V2-receptor antagonists.

This tablet is also indicated for conditions such as heart failure, liver cirrhosis, and Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH). These are circumstances where the body's sodium balance can be disturbed, leading to hyponatremia.

The dosage and frequency of this medicine should be determined by your doctor. Before starting with Tolsama 15 Tablet, ensure you inform your doctor about any pre-existing conditions or ongoing medications to avoid any complications. If you experience any side effects during the course of this medication, alert your doctor at once. For optimal results, ensure you continue taking this medicine for the duration your doctor prescribes.

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Tolsama 15 Tablet is used for managing:

Low blood sodium levels associated with heart failure
Hyponatremia related to liver cirrhosis
Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH)

Directions for Use of Tolsama 15 Tablet 4

Swallow the tablet whole with a glass of water.
Avoid crushing, chewing or breaking the tablet.
You can take this medicine with or without food, according to your preference.
If you're unsure about anything, always consult your doctor for specific advice.

Tolsama 15 Tablet is taken orally.

While taking Tolsama 15 Tablet, you may experience the following common side effects:

Thirst
Dry mouth
Increased urination
Headache
Fatigue
Dizziness
Nausea or vomiting
Constipation or diarrhoea
Back pain
Muscle cramps
Fever

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve upon discontinuing the use of Tolsama 15 Tablet. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are some tips on how to manage a couple of these side effects:

Nausea or vomiting: Try taking your medicine with food or milk to lessen this effect.
Fatigue: Consider taking this medicine at night if it causes you to feel tired during the day.

Tolsama 15 Tablet contains Tolvaptan (15 mg), which works on your body in the following ways:

Vasopressin V2-receptor Antagonism: Tolvaptan selectively blocks the binding of vasopressin, an antidiuretic hormone, to V2 receptors located in your kidneys. Vasopressin typically helps your kidneys reabsorb water back into your body. By blocking this action, Tolvaptan reduces the reabsorption of water.
Increased Free Water Excretion: Due to reduced water reabsorption, your kidneys excrete more free water. This helps to increase the concentration of sodium in your body.
Raised Serum Sodium Concentration: By increasing the excretion of free water, Tolvaptan effectively raises the concentration of sodium in your blood. This helps correct the low sodium levels associated with conditions such as heart failure, liver cirrhosis, and SIADH.

Pregnancy

Caution is advised while taking Tolsama 15 Tablet if you are pregnant. Always consult your doctor before taking this medicine.

Breastfeeding

Breastfeeding is not recommended while using Tolsama 15 Tablet. It's best to discuss this with your doctor before starting the medicine.

Alcohol

The interactions of Tolsama 15 Tablet with alcohol are not well documented. However, it's best to limit alcohol consumption while taking this medicine or discuss this with your doctor.

Liver

Tolsama 15 Tablet is not recommended for severe liver diseases. If you have any liver problems, discuss them with your doctor before starting this medicine.

Kidney

Caution is advised before using Tolsama 15 Tablet if you have a history of any kidney problems. Consult your doctor before taking this medicine.

Using Machines & Driving

Tolsama 15 Tablet might cause fatigue and dizziness. If you experience these effects, avoid driving or operating heavy machinery until you feel better.

Allergy

If you're allergic to any component of Tolsama 15 Tablet, do not take this medicine. Consult your doctor for an alternative medication.

Children

The safety and effectiveness of Tolsama 15 Tablet have not been established in children under 18 years of age. Always consult your doctor before giving this medicine to a child.

Older Patients

Older patients should take Tolsama 15 Tablet under medical supervision as they may be more susceptible to its side effects. Your doctor will guide you based on your health status.

Drug-Drug Interactions

Tolsama 15 Tablet interacts with the following medicines:

Antifungals: Medicines like ketoconazole or itraconazole increase tolvaptan exposure, potentially leading to higher side effects.
Antihypertensives: Medicines like losartan and enalapril may increase the risk of high potassium levels in your blood (hyperkalaemia) when taken with this medicine.
Potassium-sparing diuretics: Medicines like spironolactone or amiloride can also increase the risk of hyperkalaemia.
V2-receptor agonists: Medicines like desmopressin may reduce the effectiveness of Tolsama 15 Tablet.

Drug-Food Interactions

Drug-Disease Interactions

Tolsama 15 Tablet interacts with the following diseases:

Autosomal Dominant Polycystic Kidney Disease (ADPKD): Tolsama 15 Tablet should not be used in patients with ADPKD as it may exacerbate their condition.
Hypovolemic Hyponatremia: This medicine isn't recommended for individuals suffering from hypovolemic hyponatremia as it could worsen their symptoms.
Liver disease: Tolsama 15 Tablet is not recommended for those with severe liver impairment. The medicine could potentially worsen their condition.
Renal Impairment: It's not advised for patients with severe renal impairment or anuria, as clearance of tolvaptan may be reduced.

Daily Dose

The daily dose of Tolsama 15 Tablet should be taken as prescribed by your doctor. The dosage can vary depending on individual factors, such as your response to the medicine and the severity of your condition. Make sure you follow the prescribed dosage and don't exceed it without consulting your doctor.

Over Dose

If you accidentally take more than your prescribed dose of Tolsama 15 Tablet, you might experience symptoms like increased thirst and frequent urination. Don't panic, but do let your doctor know about it.

Missed Dose

If you forget to take your Tolsama 15 Tablet, take it as soon as you remember. However, if it's nearly time for your next dose, skip the missed one and continue with your regular dosing schedule. Never double up on doses without consulting your doctor.

Store Tolsama 15 Tablet at a steady room temperature below 30°C.
Keep the medicine in its original packaging, safe from direct sunlight and moisture.
Ensure your medicine is kept out of reach of children.
Always check the expiry date before using Tolsama 15 Tablet and never use it beyond this date.

Since Tolsama 15 Tablet can increase urination, make sure you drink plenty of fluids to avoid dehydration.
If you're dealing with liver cirrhosis or heart failure, excessive drinking can worsen your condition. Therefore, it's advisable to limit your alcohol consumption while taking this medicine.

Fact Box

Drug Category	Vasopressin V2-Receptor Antagonist
Therapeutic Category	Hyponatremia Management
Available Dosage Types	Tablet
Habit Forming	No
Ailment	Heart Failure, Liver Cirrhosis, SIADH

What does Tolsama 15 Tablet do?

Tolsama 15 Tablet manages low blood sodium levels by increasing the amount of water your body gets rid of through urine.

Why should Tolsama 15 Tablet not be used for more than 30 days?

Prolonged use of this medicine may lead to liver injury. Hence, it's recommended not to use it for more than 30 days.

Can Tolsama 15 Tablet be used in children?

No, the safety and effectiveness of Tolsama 15 Tablet have not been established in children.

What should I do if I miss a dose of Tolsama 15 Tablet?

If you miss a dose, take it as soon as you remember. However, skip it if it's nearly time for your next dose.

Can I take Tolsama 15 Tablet with other medicines?

Always inform your doctor about all your current medicines before starting Tolsama 15 Tablet to avoid potential interactions.

How can I manage increased thirst and urination while taking Tolsama 15 Tablet?

Always have water available to drink when you feel thirsty while on this medication. Avoid restricting your fluid intake in the first 24 hours.

Is it safe to use Tolsama 15 Tablet during pregnancy or breastfeeding?

Caution is advised in case of pregnancy while taking this medicine. Breastfeeding is not recommended while using Tolsama 15 Tablet. It's best to discuss this with your doctor before starting the medicine.

Certified Content

Written by

Dr Nikita Lobo

Medical Editor & Reviewer | 7 years

BDS, MDS

Reviewed by

Dr. Chhavi Rosha

Health & Medical Content Writer | 8 years

BMS, FMC, MD Resident

Check out Editorial Policy

Manufacturer details

MSN House, Plot No: C-24, Industrial Estate, Sanathnagar, Hyderabad, Telangana 500018

Country of origin: INDIA

References

Otsuka. (2009). Highlights of prescribing information [Prescribing information]. https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/022275s017lbl.pdf
Tolvaptan: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB06212
PubChem. (n.d.). Tolvaptan. PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/Tolvaptan
Reilly, T., & Chavez, B. (2009, October 1). Tolvaptan (Samsca) for hyponatremia: Is it worth its salt? PubMed Central (PMC). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2799145/

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