Syntran 200 Mg Capsule 10

Syntran 200 Capsule 10

Glenmark Pharmaceuticals Ltd.

STRIP of 10 Units
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Composition

Itraconazole (200 Mg)

Strength:

200 MG 100 MG

Syntran 200 Capsule is a medicine primarily used for managing systemic fungal infections. This medication falls under the category of azole antifungals, a group of medicines that combat fungal infections by inhibiting the growth of fungi.

In addition to its main role in handling systemic fungal infections, this medicine is also used for other types of fungal infections. These include skin and nail infections, oral thrush, and as a preventive measure in immunocompromised patients to prevent them from developing fungal infections.

Before you start taking this medicine, it's crucial to consult your doctor who will determine the suitable dosage and frequency for you. Make sure to inform your doctor about any pre-existing conditions or ongoing medications you're currently on. If you notice any side effects while taking this medication, notify your doctor immediately. Remember to continue taking the medicine for the duration prescribed by your doctor for optimal results.

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Syntran 200 Capsule is typically used for managing:

Severe systemic fungal infections such as aspergillosis, candidiasis, and cryptococcosis
Fungal infections of the skin and nails including onychomycosis and dermatophytosis
Oral thrush and other forms of mucosal candida infections
As a preventive measure against fungal infections in patients with compromised immune systems

Directions for Use of Syntran 200 Capsule 10

Here's how you should take Syntran 200 Capsule:

Follow the dosage and timing instructions provided by your doctor precisely.
Do not change or exceed the prescribed dose without consulting your doctor.
Consult your doctor before discontinuing the medication; do not stop taking it without their guidance.
Adhere to the dietary recommendations given by your doctor.

Syntran 200 Capsule is taken orally.

Syntran 200 Capsule may have the following common side effects:

Nausea
Vomiting
Diarrhoea
Abdominal pain
Headache
Dizziness
Rash or itching
Fatigue
Loss of appetite

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve upon discontinuing the use of Syntran 200 Capsule. However, if you experience any serious side effects or worsening of any symptoms, please consult your doctor.

Here are some general guidelines for managing common side effects:

Nausea/Vomiting: Follow the dietary recommendations provided by your doctor.
Abdominal Pain: Completely avoid consuming junk food for a few days.

Syntran 200 Capsule contains Itraconazole (200mg) which acts on the body as follows:

Inhibits Cytochrome P450 Enzyme: Itraconazole works by blocking a specific enzyme known as lanosterol 14-alpha-demethylase in fungi. This enzyme plays a pivotal role in converting lanosterol to ergosterol which is vital for maintaining the structure of the fungal cell membrane.
Increases Fungal Membrane Permeability: By preventing the synthesis of ergosterol, Itraconazole increases the permeability of the fungal membrane. This causes leakage of cellular contents leading to fungi cell death.
Clears Fungal Infections: The increased permeability and subsequent leakage culminate in arresting the growth of fungi thus helping clear up the infection caused by fungi.

Pregnancy

Syntran 200 Capsule is not recommended during pregnancy. If you are pregnant or planning to conceive, make sure to discuss this with your doctor before starting this medicine.

Breastfeeding

Syntran 200 Capsule is not advised for breastfeeding women. Consult your doctor to understand the potential risks and benefits.

Alcohol

Caution is advised while consuming alcohol during treatment with Syntran 200 Capsule. Consult your doctor for further guidance.

Liver

This medicine should be used with caution if you have liver problems. Syntran 200 Capsule may affect liver function. Discuss your liver health with your doctor before starting this medication.

Kidney

If you have kidney issues, caution is advised before using Syntran 200 Capsule. It's a good idea to consult your doctor prior to taking this medicine.

Using Machines & Driving

If you experience dizziness or vision changes after taking Syntran 200 Capsule, avoid driving or operating heavy machinery until these symptoms pass.

Allergy

Avoid Syntran 200 Capsule if you have known hypersensitivity to itraconazole or any other components of the capsule. Always inform your doctor about any allergies you may have.

Children

Caution is advised while giving Syntran 200 Capsule to children under 18 years of age. Always consult your doctor before giving any medicine to a child.

Older Patients

Older patients should take Syntran 200 Capsule under medical supervision as they might be more susceptible to its side effects, especially if they have existing liver or kidney conditions. Your doctor will guide you based on your health status.

Drug-Drug Interactions

Syntran 200 Capsule interacts with the following medicines:

Antiarrhythmics: Medicines like quinidine and dofetilide may increase the risk of arrhythmias when taken with Syntran 200 Capsule, as both could potentially prolong QT intervals.
Statins: Syntran 200 Capsule can raise the levels of simvastatin and atorvastatin in your body, which could lead to an increased risk of side effects.
Benzodiazepines: Concomitant use with midazolam or triazolam can enhance their sedative effects.
Immunosuppressants: If used with cyclosporine or tacrolimus, Syntran 200 Capsule can raise their levels and enhance their immunosuppressive effect.
Anticoagulants: The effectiveness of rivaroxaban could be increased with Syntran 200 Capsule, leading to a higher risk of bleeding.
Oral Hypoglycemics: This medicine may increase blood levels of glipizide and glyburide, which could result in low blood sugar.

Drug-Food Interactions

Consuming grapefruit juice while on this medication inhibits CYP3A4 enzymes and can increase the levels of itraconazole in your body.

Drug-Disease Interactions

Syntran 200 Capsule interacts with the following diseases:

Liver disease: People with liver problems should be careful as this medicine may exacerbate their condition.
Heart disease: Patients with ventricular dysfunction or a history of heart failure should avoid this medicine as it might worsen their condition.
Adrenal insufficiency: If you have adrenal insufficiency, this medicine may worsen your symptoms.

Daily Dose

Your doctor will prescribe the daily dosage of Syntran 200 Capsule, based on factors such as the severity of your condition and how well you respond to treatment. It's vital you stick to this prescribed dosage and avoid exceeding it without consulting your doctor.

Over Dose

Overdosing on Syntran 200 Capsule may result in common side effects like nausea, dizziness, and rash. If you suspect an overdose, inform your doctor to help manage these symptoms effectively.

Missed Dose

If you forget to take your Syntran 200 Capsule at the scheduled time, take it as soon as you remember. However, if it's close to the time for your next dose, skip the missed one and continue with your regular dosage schedule. Don't increase your dosage without consulting your doctor.

Store Syntran 200 Capsule at a comfortable room temperature below 30°C.
Protect from bright light and moisture to preserve its effectiveness.
Ensure the medicine is kept out of children's reach to prevent accidental ingestion.
Always use your Syntran 200 Capsule before the expiry date for optimal efficacy.

When managing fungal infections with Syntran 200 Capsule, ensure you maintain good personal hygiene. Regular bathing and clean clothes can help reduce fungal growth and spread.
Avoid consuming grapefruit or its juice while taking this medicine as it can increase itraconazole levels in your body, which may lead to unwanted side effects.

Fact Box

Drug Category	Azole Antifungal
Therapeutic Category	Antifungal Medicine
Available Dosage Types	Capsule
Habit Forming	No
Ailment	Aspergillosis, Candidiasis, Onychomycosis

What should I do if I forget to take a dose of Syntran 200 Capsule?

As soon as you remember, take the missed dose. If it's almost time for your next dose, skip the missed one and continue with your regular schedule.

How long does it take for Syntran 200 Capsule to start working?

The time for improvement depends on the type and severity of the fungal infection. You might observe changes within 2-4 weeks, but the complete resolution could take longer.

Can I take Syntran 200 Capsule on an empty stomach?

You must take the medicine exactly as prescribed by your doctor.

Is Syntran 200 Capsule safe to use during pregnancy or while breastfeeding?

Syntran 200 Capsule should be avoided during pregnancy and breastfeeding due to potential risks. Always consult your doctor.

How can I manage common side effects like nausea or headaches?

You can manage nausea by taking the capsule with meals and staying hydrated. Over-the-counter pain relievers can help with headaches. Consult your doctor if side effects persist.

Can I consume alcohol while taking Syntran 200 Capsule?

It is advised to avoid alcohol consumption during treatment with Syntran 200 Capsule as it may increase the risk of certain side effects.

Can I drive or operate machinery after taking this medicine?

If you experience dizziness or vision changes after taking Syntran 200 Capsule, avoid driving or operating machinery until these symptoms pass.

Certified Content

Written by

Dr Nikita Lobo

Medical Editor & Reviewer | 7 years

BDS, MDS

Reviewed by

Dr. Chhavi Rosha

Health & Medical Content Writer | 8 years

BMS, FMC, MD Resident

Check out Editorial Policy

Manufacturer details

Glenmark House, HDO-Corporate Building, Wing-A, B.D. Sawant Marg, Chakala Off. Western Express Highway, Andheri (East), Mumbai, Maharashtra, 400099 India

Country of origin: INDIA

References

DailyMed. (n.d.). Itraconazole capsule - DailyMed. Retrieved from https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=2ab38a8a-3708-4b97-9f7f-8e554a15348d&type=display
U.S. Food and Drug Administration. (2018). NDA 208901. Retrieved from https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/208901Orig1s000OtherR.pdf
Itraconazole: Uses, Interactions, Mechanism of Action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB01167
Lestner, J., & Hope, W. W. (2013). Itraconazole: an update on pharmacology and clinical use for treatment of invasive and allergic fungal infections. Expert Opinion on Drug Metabolism & Toxicology, 9(7), 911–926. https://doi.org/10.1517/17425255.2013.794785
Itraconazole: MedlinePlus Drug Information. (n.d.). https://medlineplus.gov/druginfo/meds/a692049.html
PubChem. (n.d.-j). Itraconazole. PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/itraconazole

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