Sacuval 50 Mg Tablet 10

Sacuval 50 Tablet 10

Alkem Laboratories Ltd.

Strip of 10 Units

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MRP ~~₹207~~

₹169.74

₹20.70/Units

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Composition

Sacubitril (24 Mg) + Valsartan (26 Mg)

Sacuval 50 Tablet is primarily used to manage chronic heart failure and reduced ejection fraction in adults. This is a combination medicine that falls into the category of heart failure medications.

This medicine also reduces the risk of cardiovascular death and hospitalisation for heart failure. The medicine's function is to improve the heart's performance and reduce the strain it experiences, ensuring better heart health and reducing complications.

You should take this medicine orally as directed by your doctor. It is crucial to inform your doctor about any pre-existing conditions or ongoing medications before starting this medicine. If you notice any side effects while on this medication, notify your doctor immediately. For optimal results, continue taking the medicine for the duration prescribed by your doctor.

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Sacuval 50 Tablet is used for the following:

Manages chronic heart failure by improving heart muscle contraction.
Lowers the risk of cardiovascular death.
Reduces hospitalisation for heart failure-related issues.

Directions for Use of Sacuval 50 Tablet 10

Swallow the tablet whole with a glass of water. Don't break, crush or chew it.
Don't take more than what your doctor has recommended.
It's important not to stop taking this medicine without consulting your doctor first. If you have doubts or concerns, consult your doctor.

Sacuval 50 Tablet is taken orally.

Sacuval 50 Tablet may have the following common side effects:

Low blood pressure
High potassium levels in the blood
Cough
Dizziness
Kidney problems

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve upon discontinuing the use of Sacuval 50 Tablet. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are some tips for managing common side effects:

Low blood pressure and dizziness: If you feel dizzy or faint after taking this medicine, try sitting down until it passes.
Kidney problems: Ensure to stay well hydrated by drinking plenty of water daily.

Sacuval 50 Tablet achieves its therapeutic effects through two active ingredients:

Sacubitril (24 mg): This ingredient inhibits an enzyme called neprilysin in your body. Neprilysin is responsible for breaking down peptides that relax blood vessels and eliminate sodium and fluid. By inhibiting neprilysin, sacubitril increases these peptides, leading to lower blood pressure and reduced strain on the heart.
Valsartan (26 mg): Valsartan is an angiotensin II receptor blocker. Angiotensin II is a substance that narrows blood vessels, increasing blood pressure and making the heart work harder. By blocking the action of angiotensin II, valsartan helps relax blood vessels and lower blood pressure, thereby reducing the workload on the heart.

Pregnancy

Sacuval 50 Tablet could potentially harm a foetus if taken during pregnancy. It should be discontinued as soon as pregnancy is detected.

Breastfeeding

The effects of Sacuval 50 Tablet on breastfeeding mothers are unclear. Therefore, it's best to consult your doctor before taking this medicine while lactating.

Alcohol

Caution is advised when consuming alcohol during the medication period.

Liver

If you have severe liver impairment, it is not recommended to use Sacuval 50 Tablet. Discuss your liver health history with your doctor before starting this medication.

Kidney

Sacuval 50 Tablet may affect kidney function, and caution is advised if you have a history of kidney problems. Your doctor will guide you based on your health status.

Using Machines & Driving

There's no specific information about whether Sacuval 50 Tablet affects your ability to drive or operate machinery. If you feel dizzy or unwell after taking this medicine, avoid such activities until you feel better.

Allergy

This medicine is contraindicated for patients allergic to sacubitril, valsartan or any other ingredients in the tablet. Consult your doctor if you have a history of allergies.

Children

The safety and effectiveness of Sacuval 50 Tablet in children are not known. Always consult your doctor before giving this medicine to a child.

Older Patients

Older patients should use Sacuval 50 Tablet under medical supervision as they may be more susceptible to its side effects. If you are above 70 years of age, discuss your health status with your doctor before starting this medication.

Drug-Drug Interactions

Sacuval 50 Tablet interacts with the following medicines:

ACE inhibitors: Medicines such as enalapril or lisinopril can increase the risk of angioedema if taken along with Sacuval 50 Tablet.
Potassium Supplements: These can raise potassium levels in your blood (hyperkalemia) when taken with Sacuval 50 Tablet.
NSAIDs: Medicines like ibuprofen and naproxen could reduce the blood pressure-lowering effect of Sacuval 50 Tablet and increase the risk of kidney dysfunction.
Statins: Medicines like atorvastatin or simvastatin have increased exposure when taken with Sacuval 50 Tablet.

Drug-Food Interactions

There are no known food interactions with Sacuval 50 Tablet.

Drug-Disease Interactions

Sacuval 50 Tablet interacts with the following diseases:

Liver disease: Patients with severe liver impairment should be cautious while taking this medication as it may worsen their condition.
Diabetes: If you are diabetic and taking Aliskiren, you should not use Sacuval 50 Tablet as it could lead to an increased risk of hyperkalemia, hypotension and kidney dysfunction.

Daily Dose

The daily dose of Sacuval 50 Tablet should be as prescribed by your doctor. This dosage may vary based on factors such as your health condition and how you respond to the medicine. It's crucial to follow the prescribed dosage and not exceed it without consulting your doctor.

Over Dose

An overdose of Sacuval 50 Tablet may lead to symptoms similar to its side effects, such as low blood pressure or high potassium levels in the blood. If you suspect an overdose, it is important to inform your doctor.<Put in information about what to do in case of an overdose.>

Missed Dose

If you forget to take a dose of Sacuval 50 Tablet, take it as soon as you remember. However, if it's almost time for your next dose, skip the missed one and continue with your regular dosage schedule. Never increase your dosage without consulting with your doctor.

Keep Sacuval 50 Tablet in its original packaging.
Store at a temperature below 30°C.
Protect the medicine from moisture.
Always keep out of reach of children.
Ensure to use the medicine before its expiry date.

Consuming too much salt can raise your blood pressure, making heart failure worse. Try to stick to a low-sodium diet to improve your heart health while taking Sacuval 50 Tablet.
Regular gentle exercise can help strengthen your heart. Consult your doctor for advice on what kind and how much exercise is right for you whilst managing your condition with Sacuval 50 Tablet.

Fact Box

Drug Category	Neprilysin Inhibitor, Angiotensin II Receptor Blocker
Therapeutic Category	Antihypertensive
Available Dosage Types	Tablet
Habit Forming	No
Ailment	Chronic Heart Failure, Reduced Ejection Fraction

What is Sacuval 50 Tablet used for?

Sacuval 50 Tablet is used to manage chronic heart failure and reduce the risk of cardiovascular death and hospitalisation for heart failure.

How does Sacuval 50 Tablet work?

It contains sacubitril and valsartan, which together relax blood vessels, improve blood flow, reduce the heart's workload, and decrease stress on the heart.

Can I take Sacuval 50 Tablet with food?

You must take the medicine as directed by your doctor.

What should I do if I experience side effects of Sacuval 50 Tablet?

If you experience side effects such as low blood pressure, high potassium levels or kidney problems, promptly report these symptoms to your doctor.

Is Sacuval 50 Tablet safe during pregnancy?

No, Sacuval can harm the fetus if taken during pregnancy. Discontinue as soon as pregnancy is detected and consult your doctor.

Can I take Sacuval 50 Tablet if I have diabetes?

Yes, but avoid taking it with aliskiren if you are diabetic. Regularly monitor your blood sugar levels.

How long does it take for Sacuval 50 Tablet to start working?

It starts working soon after taking it but full effects may take several weeks. Don't stop taking it without consulting your doctor.

Certified Content

Written by

Dr Nikita Lobo

Medical Editor & Reviewer | 7 years

BDS, MDS

Reviewed by

Dr. Chhavi Rosha

Health & Medical Content Writer | 8 years

BMS, FMC, MD Resident

Check out Editorial Policy

Manufacturer details

Alkem House, Senapati Bapat Marg, Lower Parel, Mumbai Maharashtra- 400013

Country of origin: INDIA

References

Novartis Pharmaceuticals Corporation. (2021). Highlights of prescribing information. https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/207620s018lbl.pdf
Entresto. (n.d.). Entresto Summary of product characteristics. https://www.ema.europa.eu/en/documents/product-information/entresto-epar-product-information_en.pdf
CARMADA. (n.d.). Sacubitril and Valsartan tablets [Report]. https://www.sanofi.in/dam/jcr:2e79c610-7644-4d4c-bf51-1651a1804410/Carmada%20PI-%20Valsartan+Secubitril-Annotated-Nov%202023.pdf
Sacubitril: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB09292
Valsartan: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB00177
Kido, K., Colvin, B. M., Szymanski, T. W., & Guglin, M. (2022). Sacubitril/Valsartan Off-Label uses for heart failure. Journal of Cardiac Failure, 28(7), 1185–1201. https://doi.org/10.1016/j.cardfail.2022.03.348

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