Pulmonext 10 Mg Tablet 10

Pulmonext 10 Tablet 10

Msn Laboratories Ltd

Strip of 10 Units

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MRP ~~₹3115~~

₹2554.3

₹311.50/Units

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Composition

Ambrisentan (10 Mg)

Strength:

5 MG 10 MG

Pulmonext 10 Tablet is primarily prescribed to manage pulmonary arterial hypertension (PAH), a condition characterised by high blood pressure in the arteries that transport blood from the heart to the lungs. It belongs to a class of medicines known as endothelin receptor antagonists.

Not only does this medicine manage PAH, but it also improves exercise ability and delays the clinical worsening of the condition. The medicine can be used alone or in combination with another medication known as tadalafil, depending on the specific medical needs of the patient.

It's important that you take this medicine orally as directed by your doctor. Inform your doctor about any pre-existing conditions or medications you're currently taking before starting this medicine. If you experience any side effects while on this medication, notify your doctor immediately. Remember to continue taking the medicine for the entire duration prescribed by your doctor to see optimal results.

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Pulmonext 10 Tablet is used for:

Management of pulmonary arterial hypertension to better exercise ability
Delaying clinical worsening in pulmonary arterial hypertension patients.

Directions for Use of Pulmonext 10 Tablet 10

To use Pulmonext 10 Tablet appropriately, follow these steps:

Swallow the tablet whole with a glass of water.
Avoid splitting, crushing or chewing the tablet.
For dosage advice specific to your health condition, it's always best to consult your doctor.

Pulmonext 10 Tablet is taken orally.

Pulmonext 10 Tablet may have the following common side effects:

Peripheral oedema: This refers to swelling in the extremities like feet or ankles.
Nasal congestion
Sinusitis
Flushing
Palpitations: This can cause a feeling of a fast-beating, fluttering or pounding heart.
Nasopharyngitis: This is inflammation of the nasopharynx, the area where the nose meets the throat.
Abdominal pain
Constipation

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing the use of Pulmonext 10 Tablet. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are some general guidelines for managing common side effects:

Abdominal pain: Try taking Pulmonext 10 Tablet with food to reduce this effect.
Constipation: Consider altering the timing of when you take this medicine, such as before going to bed.

Pulmonext 10 Tablet contains ambrisentan (10 mg) and works in the body in the following ways:

Blocks Endothelin-1 Action: Ambrisentan functions by obstructing the action of endothelin-1, a substance that narrows blood vessels, specifically on the endothelin type A (ETA) receptor present in the blood vessels of the lungs.
Reduces Blood Pressure in Pulmonary Arteries: By blocking the ETA receptors, ambrisentan dilates the blood vessels (vasodilation) and decreases the blood pressure in the pulmonary arteries, reducing the strain on the right side of the heart.

Pregnancy

Pulmonext 10 Tablet is contraindicated during pregnancy. If you are expecting or planning to conceive, it's important to discuss this with your doctor before starting this medicine.

Breastfeeding

Data regarding the use of Pulmonext 10 Tablet during breastfeeding is limited. It is advised to consult your doctor before taking this medicine if you are nursing.

Alcohol

There is no known interaction between alcohol and Pulmonext 10 Tablet. However, it's a good idea to limit your alcohol intake while on medication.

Liver

Caution is advised while taking Pulmonext 10 Tablet in case of liver impairment. This medicine may affect liver function, therefore, it's best to discuss any liver problems with your doctor before starting this medication.

Kidney

If you have a history of kidney problems, it's best to consult your doctor before starting this medicine.

Using Machines & Driving

Pulmonext 10 Tablet may cause side effects that can affect your ability to drive or operate machinery. It's recommended to avoid such activities if you experience any such side effects.

Allergy

If you are allergic to ambrisentan or any other ingredients in Pulmonext 10 Tablet, avoid using this medication. Always inform your doctor about any allergies before starting treatment.

Children

Pulmonext 10 Tablet should not be given to children under 18 years of age. Always consult your doctor before giving any medicine to a child.

Older Patients

Older patients should take Pulmonext 10 Tablet under medical supervision as they may be more susceptible to its side effects. Your doctor will guide you based on your health status.

Drug-Drug Interactions

Pulmonext 10 Tablet interacts with the following medicines:

Immunosuppressants: Concurrent use of Cyclosporine with Pulmonext 10 Tablet can result in increased exposure to ambrisentan, the active ingredient of Pulmonext 10 Tablet. This interaction necessitates a dose reduction of this medicine.
Antifungals: Medicines like ketoconazole could increase the exposure to ambrisentan when taken together with Pulmonext 10 Tablet.
Antibiotics: Medications such as rifampin could decrease the exposure to ambrisentan when taken concurrently with Pulmonext 10 Tablet.

Drug-Food Interactions

Drug-Disease Interactions

Pulmonext 10 Tablet interacts with the following diseases:

Idiopathic Pulmonary Fibrosis (IPF): Patients diagnosed with IPF should not take this medicine due to an increased risk of disease progression and mortality.
Hepatic Disease: Patients suffering from liver diseases should exercise caution while taking Pulmonext 10 Tablet, as there are reports of hepatic enzyme elevations.

Daily Dose

Your daily dose of Pulmonext 10 Tablet should be as directed by your doctor. This can vary based on factors such as the severity of your condition and how you respond to the medicine. Always follow your doctor's instructions and avoid exceeding the prescribed dosage. For further details regarding dosage, read the package insert.

Over Dose

If you happen to take more Pulmonext 10 Tablet than prescribed, you might experience common symptoms like nasal congestion, sinusitis, flushing and palpitations. If these symptoms persist or worsen, inform your doctor.

Missed Dose

In case you forget to take Pulmonext 10 Tablet at your scheduled time, take it as soon as you remember. However, if it's nearly time for your next dose, skip the missed one and continue with your regular schedule. Do not increase your dosage without consulting your doctor.

Store Pulmonext 10 Tablet at a temperature below 25°C.
Avoid exposing the medication to excess light or moisture.
Ensure the storage area is out of the reach and sight of children.
Always check the expiry date before use.

If you've been prescribed Pulmonext 10 Tablet due to pulmonary arterial hypertension, try to limit your salt intake. Excess salt can increase blood pressure and make your symptoms worse.
Regular gentle exercise, such as walking or swimming, can help improve your cardiovascular health and manage your condition. But remember, always consult your doctor before starting any new exercise regime.

Fact Box

Drug Category	Endothelin Receptor Antagonist
Therapeutic Category	Antihypertensive
Available Dosage Types	Tablet
Habit Forming	No
Ailment	Pulmonary Arterial Hypertension

What is Pulmonext 10 Tablet used for?

Pulmonext 10 Tablet is used to manage pulmonary arterial hypertension (PAH), a condition causing high pressure in the arteries from your heart to your lungs.

How does Pulmonext 10 Tablet work?

The active ingredient ambrisentan in Pulmonext 10 Tablet blocks a substance called endothelin-1, reducing blood pressure in the pulmonary arteries and easing the heart's workload.

Can Pulmonext 10 Tablet cause any side effects?

Yes, some people may experience side effects like peripheral edema (swelling), nasal congestion, sinusitis, palpitations, nasopharyngitis (common cold), abdominal pain, and constipation.

Can I take Pulmonext 10 Tablet with or without food?

You must take the medicine as directed by your doctor.

Is it safe to take Pulmonext 10 Tablet during pregnancy?

No, Pulmonext 10 Tablet should not be taken during pregnancy as it can harm the foetus. Women of reproductive potential should use effective contraception during treatment.

Can I take other medicines along with Pulmonext 10 Tablet?

Some medicines may interact with ambrisentan, the active ingredient in Pulmonext 10 Tablet. Always consult your doctor before starting any new medicine while taking Pulmonext 10 Tablet.

How should I store my Pulmonext 10 Tablets?

Store your tablets at room temperature between 20°C to 25°C. Keep them in a tightly closed container and protect them from moisture and light.

Certified Content

Written by

Dr Nikita Lobo

Medical Editor & Reviewer | 7 years

BDS, MDS

Reviewed by

Dr. Chhavi Rosha

Health & Medical Content Writer | 8 years

BMS, FMC, MD Resident

Check out Editorial Policy

Manufacturer details

MSN House, Plot No: C-24, Industrial Estate, Sanathnagar, Hyderabad, Telangana 500018

Country of origin: INDIA

References

Gilead Sciences, Inc. (2018). Highlights of prescribing information [Prescribing information]. In Letairis. https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/022081s040lbl.pdf
PHA’s Scientific Leadership Council. (2013). Ambrisentan (Letairis®). https://phassociation.org/wp-content/uploads/2018/04/Patients-Treatment-Ambrisentan-4-12-18.pdf
PubChem. (n.d.). Ambrisentan. PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/Letairis
Ambrisentan: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB06403
Oudiz, R. J., Galiè, N., Olschewski, H., Torres, F., Frost, A., Ghofrani, H. A., Badesch, D. B., McGoon, M. D., McLaughlin, V. V., Roecker, E. B., Harrison, B. C., Despain, D., Dufton, C., & Rubin, L. J. (2009). Long-Term ambrisentan therapy for the treatment of pulmonary arterial hypertension. Journal of the American College of Cardiology, 54(21), 1971–1981. https://doi.org/10.1016/j.jacc.2009.07.033

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