Oxitrofur Sr Tablet 10

Drs Alexia Pharma Private Limited

Strip of 10 UNITS

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MRP ~~₹77.88~~

₹63.86

₹7.79/UNITS

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Composition

Nitrofurantoin (100 Mg)

Oxitrofur Sr Tablet 10 is primarily used to manage uncomplicated urinary tract infections (UTIs). This oral medication falls under the class of antibacterials, specifically designed to combat various gram-positive and gram-negative pathogens.

It is also used as a preventive measure against recurring UTIs particularly during pregnancy. However, it is important to note that this medicine may not be effective against certain bacteria, such as Proteus or Pseudomonas species.

Consult your doctor for the correct dosage and frequency of this medicine. Before starting this treatment, let your doctor know about any pre-existing conditions or ongoing medications you might have. Report any side effects to your doctor immediately. For optimal results, continue taking the medicine for the duration prescribed by your doctor.

Oxitrofur Sr Tablet 10 is used for the following purposes:

Management and prevention of uncomplicated urinary tract infections (UTIs)
Managing UTIs caused by Escherichia coli, enterococci, and Staphylococcus aureus
Management of urinary infections triggered by certain gram-negative bacteria
Prophylaxis against UTIs during pregnancy

Directions for Use of Oxitrofur Sr Tablet 10

Swallow the tablet whole with a glass of water or milk to ease absorption and minimise stomach upset.
Refrain from crushing or chewing the tablet.
Do not exceed the recommended dosage without consulting your doctor.

Oxitrofur Sr Tablet 10 is taken orally.

Oxitrofur Sr Tablet 10 may have the following common side effects:

Anorexia: This refers to loss of appetite, which might make you eat less than usual.
Nausea and vomiting
Diarrhoea
Headaches
Drowsiness and dizziness
Rash

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing the use of Oxitrofur Sr Tablet 10. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are some general guidelines for managing common side effects:

Diarrhoea: To minimise this effect, try taking Oxitrofur Sr Tablet 10 with food or milk.
Drowsiness and dizziness: If this medicine makes you feel sleepy or unsteady during the day, consider taking it at night.

Oxitrofur Sr Tablet 10 contains Nitrofurantoin (100 mg). Here's how it works:

Absorption and Concentration: After you take Oxitrofur Sr Tablet 10 orally, it gets absorbed from your gastrointestinal tract and is concentrated in your urine.
Damaging Bacterial DNA: Nitrofurantoin damages bacterial DNA by inhibiting the synthesis of DNA, RNA, protein, and cell walls.
Production of Reactive Intermediates: Nitrofurantoin also causes single-strand breaks in bacterial DNA by producing reactive intermediates and free radicals.
Resistance Minimization: The multiple mechanisms through which nitrofurantoin acts help minimise the development of resistance by bacteria.

Pregnancy

Caution is advised while taking Oxitrofur Sr Tablet 10 if you are pregnant. It is best to consult your doctor before taking this medicine.

Breastfeeding

If you are breastfeeding, be aware that the Oxitrofur Sr Tablet 10 should be used with caution. Discuss this with your doctor before starting the medicine.

Alcohol

The effectiveness of nitrofurantoin can be affected due to the consumption of alcohol and may lead to adverse effects. It is advised not to consume alcohol if this medication is prescribed to you.

Liver

If you have mild to moderate liver impairment, caution is required when taking Oxitrofur Sr Tablet 10. It's not recommended if you have severe liver diseases. Discuss your liver health with your doctor before starting this medication.

Kidney

Oxitrofur Sr Tablet 10 should be used cautiously if you have a history of kidney problems. Consult your doctor before starting the medicine.

Using Machines & Driving

This medicine may cause drowsiness or dizziness in some people. If you experience these side effects, avoid driving or operating heavy machinery until you know how Oxitrofur Sr Tablet 10 affects you.

Allergy

Oxitrofur Sr Tablet 10 is contraindicated for those who are allergic to nitrofurantoin. If you've had a previous allergic reaction to this ingredient, inform your doctor before starting the medicine.

Children

Oxitrofur Sr Tablet 10 should not be given to children due to the risk of haemolytic anaemia. Always consult your doctor before administering any medication to a child.

Older Patients

Older patients should use Oxitrofur Sr Tablet 10 under medical supervision as they may be more susceptible to its side effects. Your doctor will guide you based on your health status, especially if you have liver and kidney issues or are on other medications.

Drug-Drug Interactions

Oxitrofur Sr Tablet 10 interacts with the following medicines:

Antacids: Medicines containing magnesium trisilicate can interact with Oxitrofur Sr Tablet 10, reducing its absorption and, thus, its effectiveness.
Quinolone Antibiotics: Oxitrofur Sr Tablet 10 may hinder the activity of quinolone antibiotics such as norfloxacin, ciprofloxacin, and levofloxacin.
Nephrotoxic Medicines: Medicines such as gentamicin and cisplatin might require increased monitoring when taken with Oxitrofur Sr Tablet 10.

Drug-Food Interactions

Foods do not have a significant impact on the effectiveness of Oxitrofur Sr Tablet 10. There are no known food interactions.

Drug-Disease Interactions

Oxitrofur Sr Tablet 10 interacts with the following diseases:

Renal Impairment: If you have kidney problems, taking Oxitrofur Sr Tablet 10 could lead to excessive medicine accumulation due to decreased medication clearance.
G6PD Deficiency: This medicine could cause hemolytic anaemia in patients deficient in glucose-6-phosphate dehydrogenase (G6PD), an enzyme that helps red blood cells function properly.
Diabetes: In diabetic individuals, Oxitrofur Sr Tablet 10 may affect the accuracy of urine glucose tests.

Daily Dose

The recommended dose for Oxitrofur Sr Tablet 10 should be as directed by your doctor. This dosage can vary depending on factors such as the severity of your condition and how you respond to the medicine. It's crucial to adhere to the prescribed dosage and not exceed it without consulting your doctor.

Over Dose

If you've accidentally taken more than your prescribed dose of Oxitrofur Sr Tablet 10, you might experience common side effects like nausea, vomiting, or diarrhoea in a more pronounced manner. If symptoms persist or worsen, it's necessary to inform your doctor.

Missed Dose

If you miss a dose of Oxitrofur Sr Tablet 10, take it as soon as you remember. However, if it's nearly time for your next dose, skip the missed one and continue with your regular schedule. Never adjust your dosage without discussing it with your doctor.

Keep Oxitrofur Sr Tablet 10 in a cool, dry place, ideally at room temperature between 15°C and 30°C.
Avoid exposing the medicine to light or moisture.
Always keep this medicine out of reach of children.

Drink plenty of fluids. Staying well-hydrated helps to flush the bacteria causing a urinary tract infection (UTI) out of your body.
Maintain good personal hygiene. Regular bathing and clean undergarments can help prevent UTIs.

Fact Box

Drug Category	Antibiotic
Therapeutic Category	Antibacterial
Available Dosage Types	Tablet
Habit Forming	No
Ailment	Uncomplicated UTIs, Cystitis

What is Oxitrofur Sr Tablet 10 used for?

Oxitrofur Sr Tablet 10 is primarily used to manage uncomplicated urinary tract infections (UTIs) caused by specific bacteria. It's particularly useful for UTIs during pregnancy.

How does Oxitrofur Sr Tablet 10 work?

Oxitrofur Sr Tablet 10 contains nitrofurantoin, which destroys bacterial DNA in multiple ways, reducing the chances of resistance. Its action is concentrated in the urinary tract.

What does 'Sustained-Release' mean in Oxitrofur Sr Tablet 10?

'Sustained-release' means the medicine is released slowly over time. This prolongs its action, reduces peak blood levels and minimises side effects.

Can I take Oxitrofur Sr Tablet 10 with food?

Yes, you should take a Oxitrofur Sr Tablet 10 with food or milk to minimise stomach upset and enhance absorption. Also, maintain adequate fluid intake.

What are the side effects of Oxitrofur Sr Tablet 10?

Common side effects include loss of appetite, nausea, vomiting and diarrhoea. Less common are headaches, drowsiness, dizziness, and skin rash.

Are there any precautions while taking Oxitrofur Sr Tablet 10?

Oxitrofur Sr Tablet 10 should not be taken if you have kidney impairment, certain blood disorders or known hypersensitivity to nitrofurantoin. Consult your doctor for detailed advice.

How should I store my Oxitrofur Sr Tablet 10?

Store your Oxitrofur Sr Tablet 10 in a cool, dry place at room temperature (15°C to 30°C). Keep them away from light and moisture and out of children's reach.

Certified Content

Written by

Dr Nikita Lobo

Medical Editor & Reviewer | 7 years

BDS, MDS

Reviewed by

Dr. Chhavi Rosha

Health & Medical Content Writer | 8 years

BMS, FMC, MD Resident

Check out Editorial Policy

Manufacturer details

Door No. 22/172A, Alexia Building, Sree Kerala Varma College Road, Thrikkumarakudam, Ayyanthole P O Thrissur Kl 680003 India

Country of origin: INDIA

References

Macrobid (Nitrofurantoin Capsules, USP) (monohydrate/macrocrystals). (n.d.). [Book]. https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/020064Orig1s029lbl.pdf
DailyMed - MACROBID- nitrofurantoin monohydrate and nitrofurantoin, macrocrystalline capsule. (n.d.). https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=1971e893-5fdb-41e3-a1e9-5e52deed03d1
Nitrofurantoin: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB00698
Nitrofurantoin: MedlinePlus drug information. (n.d.). https://medlineplus.gov/druginfo/meds/a682291.html

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