Napilex Cr 20087 Mg Tablet Cr 10

Napilex Cr 200/87 MG Tablet Cr 10

Mankind Pharmaceuticals Ltd.

Strip of 10 Units

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Composition

Sodium Valproate / Valproic Acid (300 Mg)

Strength:

300 MG 500 MG 500 MG 200 MG

Napilex Cr 200/87 MG Tablet Cr 10 is primarily used to manage various forms of epilepsy, a neurological disorder characterised by frequent seizures. This medication is a combination medicine belonging to a category of medicines known as antiepileptic medicines.

In addition to controlling seizures, this tablet can also be used in the management of manic episodes that are associated with bipolar disorder. The controlled-release formulation allows for maintaining steady therapeutic medicine levels.

You should take this medicine as instructed by your doctor. It's important to inform your doctor about any pre-existing health conditions or if you're currently on any other medication before starting this medicine. If you experience any side effects while taking this medicine, it's crucial to inform your doctor right away. For optimal results, continue the medicine for the duration prescribed by your doctor.

Uses of Napilex Cr 200/87 MG Tablet Cr 10

Napilex Cr 200/87 MG Tablet Cr 10 is used for the following:

Managing different forms of epilepsy, including generalised tonic-clonic seizures, absence seizures, and partial seizures with complex symptomatology.
Control of manic episodes in bipolar disorder.

Directions for Use of Napilex Cr 200/87 MG Tablet Cr 10

Swallow the tablet whole with a glass of water.
Do not crush or chew the tablet, as this can interfere with its controlled release properties.
Remember to always consult your doctor for specific advice on how to take this medicine.

Napilex Cr 200/87 MG Tablet Cr 10 is taken orally.

Side Effects of Napilex Cr 200/87 MG Tablet Cr 10

Napilex Cr 200/87 MG Tablet Cr 10 might cause the following common side effects:

Nausea
Vomiting
Indigestion
Abdominal pain
Increased appetite
Diarrhoea
Tremor: This is when you feel an unintentional rhythmic muscle movement
Sedation: This means feeling calm or sleepy

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing the use of Napilex Cr 200/87 MG Tablet Cr 10. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are some tips for managing some common side effects:

Indigestion: Try to take Napilex Cr 200/87 MG Tablet Cr 10 after meals to lessen this effect.
Sedation: If you feel sleepy after taking this medicine, consider taking it at bedtime.

How Napilex Cr 200/87 MG Tablet Cr 10 Works?

Napilex Cr 200/87 MG Tablet Cr 10 comprises two active ingredients:

Sodium Valproate (200 mg): This ingredient works mainly by increasing brain concentrations of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter. By blocking GABA degradation and activating GABA synthesis, sodium valproate suppresses abnormal neuronal excitation and hypersynchronization associated with seizures.
Valproic Acid (87 mg): Much like sodium valproate, valproic acid also increases GABA concentrations in the brain. It contributes to seizure control by potentiating GABA receptor activity and attenuating high-frequency neuronal firing through effects on voltage-gated sodium channels.

Pregnancy

Caution is advised while taking Napilex Cr 200/87 MG Tablet Cr 10 if you are pregnant. Since it can cause neural tube defects and other teratogenic effects, consulting your doctor before taking this medicine is essential.

Breastfeeding

Always consult your doctor before starting this medicine if you are breastfeeding. Your doctor will evaluate the potential risks and benefits for you and your child.

Alcohol

It's best to avoid consuming alcohol when taking Napilex Cr 200/87 MG Tablet Cr 10. Alcohol may interact with this medicine, potentially enhancing side effects.

Liver

If you have liver problems or suffer from significant hepatic dysfunction, Napilex Cr 200/87 MG Tablet Cr 10 is contraindicated. This medicine may affect liver function, so discussing these concerns with your doctor before starting treatment is advisable.

Kidney

If you have a history of any kidney problems, caution is advised before using Napilex Cr 200/87 MG Tablet Cr 10. Consult your doctor to understand the potential risks and benefits.

Using Machines & Driving

This medicine may cause side effects such as dizziness, sedation, or confusion. If you experience these symptoms, do not drive or operate heavy machinery until they subside.

Allergy

Napilex Cr 200/87 MG Tablet Cr 10 is contraindicated if you have known hypersensitivity to sodium valproate, valproic acid or any ingredients in this medicine. Please share any allergy history with your doctor.

Children

This medicine should not be given to children under 2 years of age due to the increased risk of hepatotoxicity. Always consult your doctor before giving any medicine to a child.

Older Patients

Older patients should take Napilex Cr 200/87 MG Tablet Cr 10 under medical supervision as they may be more susceptible to its side effects. Your doctor will guide you based on your health status.

Interactions of Napilex Cr 200/87 MG Tablet Cr 10

Drug-Drug Interactions

Napilex Cr 200/87 MG Tablet Cr 10 interacts with the following medicines:

Antiepileptics: Napilex Cr 200/87 MG Tablet Cr 10 can increase the levels of antiepileptic medicines such as phenytoin and carbamazepine, which may require dose adjustments.
Pain relievers: The interaction with aspirin may lead to heightened valproate levels, increasing the risk of toxicity.
Benzodiazepines: Taking this medicine with benzodiazepines like diazepam and alprazolam can cause increased sedation.
Antiretrovirals: When taken with zidovudine, there's a risk of elevated zidovudine levels in your blood, which could lead to toxicity.
Anticoagulants: Concomitant take with warfarin may heighten your risk of bleeding due to possible interference with clotting mechanisms.

Drug-Food Interactions

There are no known specific food interactions with the Napilex Cr 200/87 MG Tablet Cr 10. However, it is generally recommended to take it after meals to reduce gastrointestinal side effects.

Drug-Disease Interactions

Napilex Cr 200/87 MG Tablet Cr 10 interacts with the following diseases:

Hepatic Disease: If you have liver disease or significant hepatic dysfunction, using this medicine can exacerbate your condition.
Urea Cycle Disorders: This medicine should not be taken if you have known urea cycle disorders as it can cause high blood ammonia levels, leading to lethargy and vomiting.
Porphyria: People suffering from porphyria, a group of genetic disorders affecting the nervous system and skin, must avoid this medication as it can trigger an attack.

Dosage of Napilex Cr 200/87 MG Tablet Cr 10

Daily Dose

Your doctor will decide the recommended dose of Napilex Cr 200/87 MG Tablet Cr 10 based on your responses and the severity of your condition. Always follow the prescribed dosage.

Over Dose

In case of an overdose, you may experience symptoms like drowsiness or confusion. If these symptoms persist, inform your doctor promptly. Never exceed the prescribed dosage.

Missed Dose

If you miss a dose of Napilex Cr 200/87 MG Tablet Cr 10, take it as soon as you remember. If it’s time for your next dose, skip the missed one. Continue with your regular schedule.

Keep Napilex Cr 200/87 MG Tablet Cr 10 in a cool, dry place, ideally at temperatures not exceeding 30°C.
Ensure the medicine is not exposed to direct sunlight or moisture.
Always store the tablet out of reach of children.

If you're managing epilepsy with the Napilex Cr 200/87 MG Tablet Cr 10, try to maintain a regular sleep schedule. Disturbances in sleep can trigger seizures.
For those taking the medicine for bipolar disorder, reducing caffeine intake can help manage manic episodes, as caffeine can increase anxiety and disrupt sleep patterns.

Fact Box

Drug Category	GABA Enhancer
Therapeutic Category	Antiepileptic
Available Dosage Types	Tablet
Habit Forming	No
Ailment	Epilepsy, Bipolar Disorder

What is Napilex Cr 200/87 MG Tablet Cr 10 used for?

Napilex Cr 200/87 MG Tablet Cr 10 is used to manage various types of epilepsy and manic episodes associated with bipolar disorder.

How does Napilex Cr 200/87 MG Tablet Cr 10 work?

This medicine increases brain concentrations of gamma-aminobutyric acid (GABA), a substance that reduces abnormal neuronal excitement linked to seizures.

Can I stop taking Napilex Cr 200/87 MG Tablet Cr 10 if I feel better?

No, you should not stop taking this medicine without consulting your doctor, as sudden discontinuation can lead to serious health issues.

Can I crush or chew Napilex Cr 200/87 MG Tablet Cr 10?

No, the tablet must be swallowed whole. Crushing or chewing it will disturb its controlled release properties.

What should I do if I miss a dose of Napilex Cr 200/87 MG Tablet Cr 10?

If you miss a dose, take it as soon as you remember. However, if it's nearly time for your next dose, skip the missed one. Continue with your regular schedule.

What are the potential side effects of Napilex Cr 200/87 MG Tablet Cr 10?

Common side effects include nausea, vomiting, increased appetite, tremors, dizziness and weight gain. Inform your doctor immediately if you experience severe side effects.

Can pregnant women take Napilex Cr 200/87 MG Tablet Cr 10?

Pregnant women should consult their doctor before taking this medicine due to the risk of birth defects in the baby.

Certified Content

Written by

Dr Nikita Lobo

Medical Editor & Reviewer | 7 years

BDS, MDS

Reviewed by

Dr. Divya Chauhan

Medical Writer & Reviewer | 6 years

BAMS, APG, PG

Check out Editorial Policy

Manufacturer details

208, Okhla Industrial Estate, Phase-III, New Delhi South Delhi DL 110020 IN

Country of origin: INDIA

References

Valproic acid: Uses, Interactions, Mechanism of Action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB00313
Valproic acid: MedlinePlus drug information. (n.d.). https://medlineplus.gov/druginfo/meds/a682412.html
Website, N. (2024, April 24). Sodium valproate. nhs.uk. https://www.nhs.uk/medicines/sodium-valproate/
National Center for Biotechnology Information (2024). PubChem Compound Summary for CID 16760703, Valproate Sodium. Retrieved June 21, 2024 from https://pubchem.ncbi.nlm.nih.gov/compound/Valproate-Sodium
Website, N. (2024, April 30). Valproic acid. nhs.uk. https://www.nhs.uk/medicines/valproic-acid/

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