N Met G2 2500 Mg Tablet 15

N Met G2 2/500mg Tablet 15

Dr. Reddys Laboratories Ltd

Strip of 15 Units

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Composition

Glimepiride (2 Mg) + Metformin (500 Mg)

N Met G2 2/500mg Tablet 15 is primarily used to manage type 2 diabetes mellitus. This oral medication is a combination medicine, part of a group of medicines known as sulfonylureas and biguanides.

This medication also helps prevent or delay the long-term complications of diabetes, including kidney damage, blindness, nerve problems, loss of limbs, and heart disease.

Before starting this medication, it's crucial to consult your doctor about your dosage and frequency. Also, inform your doctor about any pre-existing conditions or ongoing medications you are taking. If any side effects occur while taking this medicine, inform your doctor immediately. For optimal results, continue taking the medicine for the duration prescribed by your doctor.

N Met G2 2/500mg Tablet 15 is used for the following:

Managing blood glucose levels in adults with type 2 diabetes mellitus
Enhancing the effect of diet and exercise in controlling blood sugar levels
Supporting glycemic control when monotherapy with either glimepiride or metformin does not adequately manage blood sugar
Delaying or preventing long-term complications of diabetes like kidney damage, blindness, nerve problems, loss of limbs, and heart disease

Directions for Use of N Met G2 2/500mg Tablet 15

Here are the instructions to follow while taking N Met G2 2/500mg Tablet 15:

Swallow the tablet whole with a glass of water.
Do not crush, chew, or split the tablet.
It is important to maintain a regular meal pattern and avoid skipping meals.
If you have doubts about dosages or timings, always consult your doctor.

N Met G2 2/500mg Tablet 15 is taken orally.

Side Effects of N Met G2 2/500mg Tablet 15

N Met G2 2/500mg Tablet 15 may result in the following common side effects:

Hypoglycaemia
Nausea
Vomiting
Diarrhoea
Flatulence (excessive gas or wind)
Asthenia (feeling unusually weak or tired)
Dizziness

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing the use of N Met G2 2/500mg Tablet 15. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

N Met G2 2/500mg Tablet 15 contains two active ingredients:

Glimepiride (2 mg): As a sulfonylurea, glimepiride stimulates insulin secretion from pancreatic beta cells. It does so by binding to sulfonylurea receptors on these cells, closing ATP-sensitive potassium channels. This action leads to cell membrane depolarization and an influx of calcium, resulting in increased insulin secretion.
Metformin (500 mg): As a biguanide, metformin reduces glucose production by the liver and delays glucose absorption from the intestines. It does this by activating AMP-activated protein kinase (AMPK), a liver enzyme that plays a key role in insulin signalling and glucose metabolism. This enhances insulin sensitivity and increases peripheral glucose uptake and utilization.

These two components work in complementary ways to effectively lower blood sugar levels.

Pregnancy

N Met G2 2/500mg Tablet 15 should not be taken during pregnancy without consulting a doctor. Poorly controlled diabetes during pregnancy can increase maternal and fetal risks, so it's essential to discuss your condition with your doctor.

Breastfeeding

If you are breastfeeding, caution is advised. Metformin, one of the components of N Met G2 2/500mg Tablet 15, is known to pass into breast milk, potentially causing hypoglycaemia in nursing infants. It is best to consult your doctor before using this medication while breastfeeding.

Alcohol

Alcohol can interfere with the effectiveness of this medicine and increase the risk of lactic acidosis, a rare but serious side effect of metformin. Avoid consuming alcohol while on this medication.

Liver

If you have liver disease, you should avoid using N Met G2 2/500mg Tablet 15 as it may increase the risk of lactic acidosis. Discussing your liver health status with your doctor before starting this medicine is recommended.

Kidney

N Met G2 2/500mg Tablet 15 should not be used if you have severe kidney impairment as it could increase the risk of lactic acidosis. If you have any kidney problems, consult your doctor before taking this medicine.

Using Machines & Driving

It is wise to monitor how your body responds to this medication. If you experience side effects like dizziness or low blood sugar levels (hypoglycaemia), be cautious while driving or operating machines.

Allergy

Do not use N Met G2 2/500mg Tablet 15 if you are allergic to glimepiride, metformin, or any other ingredients in this medicine. If you experience any allergic reactions, such as skin rash or itching, stop the medication and contact your doctor immediately.

Children

This medicine is intended for adults. It's not recommended for children as its safety and efficacy in children have not been established.

Older Patients

Older patients should take N Met G2 2/500mg Tablet 15 under medical supervision as they may be more susceptible to its side effects. Special care is needed if you are above 70 years of age, especially if you have liver or kidney issues. Your doctor will provide guidance based on your health status.

Interactions of N Met G2 2/500mg Tablet 15

Drug-Drug Interactions

N Met G2 2/500mg Tablet 15 may interact with the following medicines:

Anti-Diabetic Medications: If you take insulin or thiazolidinediones with this tablet, your risk of low blood sugar (hypoglycaemia) can increase.
Blood Pressure Regulating Medicines: Beta-blockers like propranolol, clonidine, or guanethidine can hide symptoms of low blood sugar when taken with this medication.
Steroid and Hormonal Medicines: Thiazides, corticosteroids, thyroid medications, estrogens, oral contraceptives, and phenytoin may lower blood sugar control when taken with N Met G2 2/500mg Tablet 15.
Diuretics and Sympathomimetics: These can lessen the glucose-lowering effect of this tablet.

Drug-Food Interactions

Certain foods can interact with N Met G2 2/500mg Tablet 15. Foods high in sugar can affect the effectiveness of this medicine by increasing blood glucose levels.

Drug-Disease Interactions

N Met G2 2/500mg Tablet 15 interacts with the following diseases:

Kidney Disease: If you have severe kidney issues (eGFR below 30 mL/min/1.73m2), using this medication may worsen your condition.
Liver Disease: People with liver problems should avoid using N Met G2 2/500mg Tablet 15 as it might increase their risk of lactic acidosis.
Congestive Heart Failure: If you have heart failure that needs medicine treatment, taking this tablet might not be advisable.

Daily Dose

The daily dose of N Met G2 2/500mg Tablet 15 should be taken as recommended by your doctor. Changes in dosage might be needed based on how your body responds and the severity of your condition. Always adhere to the prescribed dosage. It's crucial not to exceed this without consulting your doctor.

Over Dose

If you accidentally take more than the prescribed dose of N Met G2 2/500mg Tablet 15, you may feel dizzy, sweat excessively, or experience a rapid heartbeat. In such a case, speak with your doctor immediately.

Missed Dose

If you forget to take an N Met G2 2/500mg Tablet 15 dose, take it as soon as you remember. However, if it's close to your next dose, skip the missed one and go back to your regular dosage plan. Never double up on doses without checking with your doctor first.

Always store N Met G2 2/500mg Tablet 15 under 30°C in a cool, dry place.
Keep away from direct light and moisture.
Ensure the medication is kept well out of reach of children.
Remember to use this medicine before its expiry date.

Include fibre-rich foods like whole grains, fruits, and vegetables in your diet. These can help manage blood sugar levels effectively, supporting the action of N Met G2 2/500mg Tablet 15.
Regular physical activity is essential. A daily walk or exercise routine can improve insulin sensitivity and help in managing type 2 diabetes.

Fact Box

Drug Category	Insulin secretagogue, Biguanide
Therapeutic Category	Antidiabetic
Available Dosage Types	No
Habit Forming	No
Ailment	Type 2 diabetes mellitus

What is N Met G2 2/500mg Tablet 15 used for?

N Met G2 2/500mg Tablet 15 is used to manage type 2 diabetes in adults. It helps lower blood glucose levels.

How does N Met G2 2/500mg Tablet 15 work?

This tablet contains two ingredients: glimepiride, which increases insulin production, and metformin, which reduces glucose production in the liver and improves insulin sensitivity.

When should I take N Met G2 2/500mg Tablet 15?

Always follow your doctor's instructions regarding the dosage and frequency of this medicine.

Can I drink alcohol while taking N Met G2 2/500mg Tablet 15?

You should avoid alcohol as it can increase your risk of hypoglycaemia (low blood sugar) and lactic acidosis (a serious metabolic condition).

Can I take this medicine if I'm pregnant or breastfeeding?

Consult your doctor before taking N Met G2 2/500mg Tablet 15 if you're pregnant or breastfeeding, as it may not be suitable.

What are the possible side effects of N Met G2 2/500mg Tablet 15?

Common side effects include hypoglycaemia, nausea, diarrhoea, flatulence, weakness, headaches, dizziness and skin rash.

What precautions should I take while using N Met G2 2/500mg Tablet 15?

Monitor your blood glucose levels regularly, maintain a healthy diet and exercise routine, and inform your doctor if you are planning a pregnancy.

Certified Content

Written by

Ashmita Borgohain

Medical Content Writer & Editor | 12 years

MSc (Applied Genetics)

Reviewed by

Dr. Meenakshi Maruwada

Medical Content Writer & Strategist | 8 years

BDS, PGCAD, GMHE (IIM-B)

Check out Editorial Policy

Manufacturer details

Bigshare Services Pvt. Ltd. 306, Right Wing, 3rd Floor Amrutha Ville, Opp.Yash Hyderabad - 500082 Telangana

Country of origin: INDIA

References

MedlinePlus. (2022). Glimepiride. U.S. National Library of Medicine. Retrieved from https://medlineplus.gov/druginfo/meds/a696016.html
MedlinePlus. (2022). Metformin. U.S. National Library of Medicine. Retrieved 1 April 2024, from https://medlineplus.gov/druginfo/meds/a696005.html
U.S. Food and Drug Administration. (2011). Glimepiride tablets. FDA. Retrieved from https://www.accessdata.fda.gov/drugsatfda_docs/psg/Glimepiride_tab_20496_RC11-04.pdf
U.S. Food and Drug Administration. (2006). Metformin hydrochloride tablets. FDA. Retrieved from https://www.accessdata.fda.gov/drugsatfda_docs/label/2006/021748s002lbl.pdf
Metformin hydrochloride | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/salts/DBSALT000114
PubChem. (n.d.-h). Metformin Hydrochloride. PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/Metformin-hydrochloride

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