Mymarda 50 Mg Tablet 10

Mymarda 50 Tablet 10

Macleods Pharmaceuticals Pvt.ltd

Strip of 10 Units

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MRP ~~₹136.4~~

₹111.85

₹13.64/Units

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Composition

Sacubitril (24 Mg) + Valsartan (26 Mg)

Mymarda 50 Tablet is primarily used for the management of chronic heart failure. This combination medicine belongs to the category of cardiovascular medications.

In addition to managing heart failure, it also aids in reducing the risk of cardiovascular death and hospitalisation. Notably, this tablet is effective for patients who have been stabilised on individual components of this medicne and who are already on an ACE inhibitor or ARB.

Before you start taking this medicine, ensure you consult your doctor, who will determine the correct dosage and frequency based on your health condition and response to treatment. Always inform your doctor about any pre-existing conditions or ongoing medications you might be taking. If you experience any side effects while on this medicine, notify your doctor immediately. It's important to continue taking the medicine for the duration prescribed by your doctor for optimal results.

Mymarda 50 Tablet is used for the following:

Management of chronic heart failure symptoms
Reduction of the risk of cardiovascular death in adults
Lowering the likelihood of hospitalisation due to heart complications
Assisting in the optimal control of reduced ejection fraction in adults

Directions for Use of Mymarda 50 Tablet 10

Here's how you should take Mymarda 50 Tablet:

Thoroughly follow the dosage prescribed by your doctor.
Ensure you do not exceed or alter the dose without your doctor's advice.
It's crucial not to stop taking this medicine abruptly. Always consult your doctor before deciding to stop.

Mymarda 50 Tablet is taken orally.

Mymarda 50 Tablet may have the following common side effects:

Low blood pressure.
Hyperkalemia (high levels of potassium in your blood)
Cough
Dizziness
Swelling of the face, lips, tongue, or throat

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing the use of Mymarda 50 Tablet. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are some general guidelines for managing common side effects:

Hypotension: If you experience dizziness or light-headedness due to low blood pressure, contact your doctor immediately.
Dizziness: If you feel dizzy after taking this medicine, seek help from your doctor and do as directed.

The Mymarda 50 Tablet is a combination medication containing two active ingredients:

Sacubitril (24 mg): This active component gets transformed into LBQ657 in your body. LBQ657 inhibits an enzyme called neprilysin which normally breaks down certain substances in your body that can cause fluid to be retained. By inhibiting neprilysin, sacubitril increases the levels of these substances, resulting in more fluid being expelled from the body via urine, decreased blood volume, and reduced workload on your heart.
Valsartan (26 mg): As an angiotensin II receptor blocker (ARB), valsartan prevents a substance known as angiotensin II from acting on receptors in your blood vessels and adrenal gland. This action results in dilation of blood vessels, reduction in blood pressure, and decreased secretion of aldosterone, a hormone that can cause salt and fluid retention.

Together, these two components provide comprehensive control over key factors contributing to heart failure symptoms and progression.

Pregnancy

Mymarda 50 Tablet is contraindicated during pregnancy. If you are pregnant or planning to conceive, make sure to discuss this with your doctor before starting this medicine.

Breastfeeding

Mymarda 50 Tablet is contraindicated for breastfeeding women. You should consult your doctor to understand the potential risks and benefits.

Alcohol

While there's no specific information on the interaction of Mymarda 50 Tablet with alcohol, it's always wise to limit alcohol intake when you are on medication. Excessive alcohol can affect your overall health and might interfere with how the medicine works.

Liver

Caution is advised while taking Mymarda 50 Tablet in case of mild to moderate liver impairment. It is not recommended for severe liver diseases. If you have liver problems, discuss them with your doctor before starting this medicine.

Kidney

Use of Mymarda 50 Tablet should be done with caution if you have a history of kidney problems. Your doctor will guide you based on your health status.

Using Machines & Driving

This medicine may cause dizziness which could affect your ability to drive or operate machinery. If you experience any such side effects, avoid driving or operating heavy machinery until you feel better.

Allergy

If you are allergic to sacubitril or valsartan, or any other ingredients in Mymarda 50 Tablet, let your doctor know before starting this medicine.

Children

Caution is advised while giving Mymarda 50 Tablet to children under 18 years of age. Always consult your doctor before giving any medicine to a child.

Older Patients

Older patients should take Mymarda 50 Tablet under medical supervision as they may be more susceptible to its side effects. Caution is advised if patients are above 70 years of age. Your doctor will guide you based on your health status.

Drug-Drug Interactions

Mymarda 50 Tablet interacts with the following medicines:

ACE inhibitors: Medicines like enalapril or lisinopril should not be taken with Mymarda 50 Tablet as this can increase the risk of angioedema, a serious allergic reaction.
Potassium-sparing diuretics and potassium supplements: Taking these with Mymarda 50 Tablet could result in excessively high levels of potassium in your blood, a condition known as hyperkalaemia.
NSAIDs: Medicines like ibuprofen and naproxen may reduce the blood pressure-lowering effect of this medicine and increase the risk of kidney problems.

Drug-Food Interactions

Mymarda 50 Tablet does not have any interactions with any specific foods.

Drug-Disease Interactions

Mymarda 50 Tablet interacts with the following diseases:

Liver disease: If you have severe liver problems, you should avoid using Mymarda 50 Tablet as it could worsen your condition.
Diabetes: This medicine can affect your blood glucose levels. Hence, if you are diabetic, regular blood sugar monitoring is necessary when on this medication.

Daily Dose

The daily dose of Mymarda 50 Tablet should be as your doctor recommends. The dosage could change depending on the seriousness of your condition and how you respond to the medicine. It's important to stick to the dosage your doctor has prescribed and not exceed it without consulting them.

Over Dose

In case of an accidental overdose, you may experience symptoms like low blood pressure and dizziness. If you notice these or any other unusual symptoms, inform your doctor.

Missed Dose

If you forget to take your Mymarda 50 Tablet, take it as soon as you remember. However, if it's nearly time for your next dose, skip the missed one and follow your regular dosage schedule. Always consult with your doctor before making any changes to your dosage.

Store your Mymarda 50 Tablet at room temperature, ideally between 15°C to 30°C.
Keep the medicine in its original packaging to protect it from moisture.
Place it in a safe location, out of reach of children.
Always check the expiry date before use and avoid using the tablet if it has expired.

Since Mymarda 50 Tablet is used to manage heart failure, maintaining a low-sodium diet can help reduce fluid buildup and lessen the burden on your heart.
Regular gentle exercise, like walking or cycling, can help strengthen your heart and improve cardiovascular health. However, remember to consult your doctor before starting any exercise regimen.

Fact Box

Drug Category	Neprilysin Inhibitor, Angiotensin II Receptor Blocker
Therapeutic Category	Antihypertensive
Available Dosage Types	Tablet
Habit Forming	No
Ailment	Chronic Heart Failure, Reduced Ejection Fraction

What is Mymarda 50 Tablet used for?

Mymarda 50 Tablet manages chronic heart failure, reducing the risk of cardiovascular death and hospitalisation in adults with reduced ejection fraction.

How does Mymarda 50 Tablet work

It combines sacubitril and valsartan. Sacubitril increases urine output and reduces cardiac workload, while valsartan lowers blood pressure and decreases aldosterone secretion.

Can I take Mymarda 50 Tablet with food?

It's recommended to take Mymarda 50 Tablet with food for optimal absorption and reduced risk of stomach irritation.

What precautions should I take while using Mymarda 50 Tablet?

Monitor your blood pressure regularly, avoid potassium-rich foods, and consult your doctor if you experience any side effects like dizziness or facial swelling.

What are the common side effects of Mymarda 50 Tablet?

Common side effects include low blood pressure, high blood potassium levels, cough, dizziness, renal impairment, and face or throat swelling.

Are there any medicines that cannot be taken along with Mymarda 50 Tablet?

Avoid taking ACE inhibitors, potassium-sparing diuretics, potassium supplements, and NSAIDs alongside Mymarda 50 Tablet. Always inform your doctor about all medications you're taking.

How should I store Mymarda 50 Tablet?

Store at room temperature (15°C to 30°C) in its original package to protect from moisture. Keep it out of reach of children.

Certified Content

Written by

Dr. Sachin Singh

Medical Team Lead | 5 years

MBBS

Reviewed by

Dr. Mandeep Chadha

Lead Medical Content Reviewer | 10 years

MBBS, DNB (OBGY)

Check out Editorial Policy

Manufacturer details

Atlanta Arcade, Marol Church Rd, Bori Colony, Vijay Nagar Colony West, Marol, Andheri East, Mumbai, Maharashtra 400059

Country of origin: INDIA

References

Cada, D. J., Baker, D. E., & Leonard, J. (2015). Sacubitril/Valsartan. Hospital Pharmacy, 50(11), 1025–1036. https://doi.org/10.1310/hpj5011-1025
U.S. Food and Drug Administration. (2016). Drug Approval Package: Entresto (sacubitril and valsartan). Retrieved 1 April 2024, from https://www.fda.gov/media/134841/download
CLINICAL PHARMACOLOGY REVIEW. (2007). https://www.fda.gov/media/71520/download
DailyMed - ENTRESTO- sacubitril and valsartan tablet, film coated ENTRESTO- sacubitril and valsartan pellet. (n.d.). https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=000dc81d-ab91-450c-8eae-8eb74e72296f
Sacubitril: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB09292
Valsartan: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB00177

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