Macsita M 501000 Mg Tablet 10

Macsita M 50/1000 Tablet 10

Macleods Pharmaceuticals Pvt.ltd

Strip of 10 Units

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Composition

Metformin (1000 Mg) + Sitagliptin (50 Mg)

Macsita M 50/1000 Tablet 10 is used to manage type 2 diabetes mellitus in adults. It's a combination medicine that falls into the category of antidiabetic medications.

In addition to its main use, this medicine improves blood sugar control when either metformin or sitagliptin alone is insufficient. It offers an easy alternative in taking separate tablets of metformin and sitagliptin. It helps lower the risk of diabetes-related complications such as kidney damage, blindness, nerve problems, heart-related issues, and sexual dysfunction.

Make sure to inform your doctor about any pre-existing conditions you may have or any other medications you are currently taking. If you experience any side effects while using this medicine, notify your doctor immediately. For best results, continue taking this medication for the duration your doctor prescribes.

Macsita M 50/1000 Tablet 10 is used for the management of Type 2 Diabetes Mellitus.

Directions for Use of Macsita M 50/1000 Tablet 10

Swallow the tablet whole with a glass of water during meals.
Do not break, chew, or crush the tablet.
Follow your doctor's instructions about when and how to take this medicine.
Stick to your prescribed dose and avoid taking more without your doctor's advice.

Macsita M 50/1000 Tablet 10 is taken orally.

Side Effects of Macsita M 50/1000 Tablet 10

Macsita M 50/1000 Tablet 10 may have the following common side effects:

Diarrhoea
Nausea
Vomiting
Abdominal pain
Headache
Upper respiratory tract infections like a running nose, sore throat and coughing
Flatulence in stomach
Low blood sugar levels

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing Macsita M 50/1000 Tablet 10. However, if you experience serious side effects or worsening symptoms, please consult your doctor.

Here are some general tips for managing common side effects:

Diarrhoea: Take Macsita M 50/1000 Tablet 10 with food to lessen this effect.
Hypoglycemia: If low blood sugar occurs after taking this tablet, consider consuming some quick source of sugar like fruit juice or glucose.

Macsita M 50/1000 Tablet 10 contains two active ingredients:

Sitagliptin (50 mg): This component works by increasing insulin release from the pancreas and reducing glucagon secretion in a manner that is dependent on glucose levels. It achieves this by inhibiting an enzyme known as DPP-4. This action boosts the effects of the incretins GLP-1 and GIP, which stimulate insulin production and release.
Metformin (1000 mg): This ingredient reduces the production of glucose in the liver, decreases the absorption of glucose from the intestines, and enhances insulin sensitivity, which results in increased uptake and use of glucose in the body's peripheral areas.

Pregnancy

If you are pregnant or planning to conceive, it's essential to consult your doctor before starting Macsita M 50/1000 Tablet 10. It should only be used if clearly needed, and the potential benefits outweigh any risks.

Breastfeeding

It's known that metformin, one of the components of Macsita M 50/1000 Tablet 10, is excreted into human breast milk. It's best to discuss with your doctor about the safest way to feed your baby while taking this medication.

Alcohol

Avoid consuming alcohol while taking this medicine, as it can increase the risk of lactic acidosis and hypoglycaemia.

Liver

Macsita M 50/1000 Tablet 10 should be used with caution if you have liver problems. Please consult your doctor for guidance.

Kidney

This medicine may not be suitable if you have severe kidney problems or undergoing dialysis. If you have any moderate kidney impairment, you may need a dosage adjustment. It is wise to discuss this with your doctor before starting this medication.

Using Machines & Driving

This medicine may cause dizziness or blurred vision. So, be cautious when driving or operating machinery . Please consult with your doctor for the best advice.

Allergy

Macsita M 50/1000 Tablet 10 is unsuitable for those with a known allergy to sitagliptin or metformin. Consult your doctor before taking this medicine.

Children

This medicine is formulated for adults and should not be given to children under 18 without medical supervision. Always consult your doctor before giving this medicine to a child.

Older Patients

Older patients should take Macsita M 50/1000 Tablet 10 under medical supervision as they may be more susceptible to its side effects. If you are above 70 or have liver and kidney issues, your doctor will guide you based on your health status.

Interactions of Macsita M 50/1000 Tablet 10

Drug-Drug Interactions

Macsita M 50/1000 Tablet 10 interacts with the following medicines:

Insulin and insulin secretagogues: Medicines like glimepiride or gliclazide can increase the risk of low blood sugar or hypoglycaemia when taken with this medication.
Salicylates: Medicines such as aspirin can enhance the glucose-lowering effect of this tablet, leading to higher chance of hypoglycaemia.

Drug-Food Interactions

Macsita M 50/1000 Tablet 10 has interactions with certain foods:

High-calorie foods: Consuming these while taking this medicine could reduce effectiveness in controlling your blood sugar.

Drug-Disease Interactions

Macsita M 50/1000 Tablet 10 interacts with the following diseases:

Renal disease: This medicine could worsen your condition if you have severe kidney problems. Therefore, it is not recommended for those with severe renal impairment.
Heart disease: This medication should be used with caution in patients having heart disease requiring pharmacologic management as it could exacerbate their condition.
Liver disease: This tablet should be taken cautiously if you have liver problems, as it could increase metformin levels and risk of lactic acidosis.

Daily Dose

The daily dose of Macsita M 50/1000 Tablet 10 should be taken as advised by your doctor. The dosage can vary depending on individual factors such as your health condition and how you respond to the medicine. It is critical to adhere to the prescribed dosage.

Over Dose

If you accidentally take more than the prescribed dose of Macsita M 50/1000 Tablet 10, it may cause symptoms like nausea, diarrhoea, and stomach discomfort. If these symptoms persist or worsen, inform your doctor.

Missed Dose

If you forget to take a Macsita M 50/1000 Tablet 10 dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed one and continue with your regular schedule. Never alter your dose without consulting your doctor.

Store Macsita M 50/1000 Tablet 10 at room temperature below 30°C.
Keep away from sun light and moisture.
Safeguard it from children and pets.
Ensure you use this medicine before its expiry date.

Maintain a balanced, low-sugar diet: Aim to include whole grains, lean proteins, fruits and vegetables in your meals. This helps manage blood sugar levels when taking Macsita M 50/1000 Tablet 10.
Regular physical activity: Moderate exercise, like walking or cycling for at least 30 minutes daily, assists in controlling your blood sugar levels and improves the effectiveness of your medication. Always consult your doctor before starting any new exercise regimen.

Fact Box

Drug Category	DPP-4 inhibitor, Biguanide
Therapeutic Category	Antidiabetic
Available Dosage Types	Tablet
Habit Forming	No
Ailment	Type 2 Diabetes mellitus

What should I do if I miss taking Macsita M 50/1000 Tablet 10?

If you forget to take your tablet, consume it as soon as you remember. However, skip if it is nearly time for the next dose. Never adjust your dosage without consulting your doctor.

How soon can I expect to see results from Macsita M 50/1000 Tablet 10?

The tablet starts lowering your blood sugar within two weeks, reaching maximum effectiveness in 4 to 8 weeks. Yet, it might take up to three months for full benefits. Consult your doctor for individualized directions and advice.

Can I continue using Macsita M 50/1000 Tablet 10 during pregnancy or breastfeeding?

Consult with your doctor before using this medicine during pregnancy or while nursing. It should be considered only if the potential benefits outweigh any risks.

Are there any specific activities or foods that I should avoid while on Macsita M 50/1000 Tablet 10?

Avoid high-calorie foods while taking this medicine, as it could reduce its effectiveness in controlling blood sugar. Be careful while driving or operating machinery until you know how this medication affects you.

Can Macsita M 50/1000 Tablet 10 cause side effects?

Common side effects include gastrointestinal issues like diarrhoea, nausea, headaches, and upper respiratory tract infections. If symptoms persist or worsen, consult your doctor.

Can I stop taking Macsita M 50/1000 Tablet 10 if my symptoms improve?

Do not stop taking the medicine without consulting your doctor, even if your symptoms improve.

Can other medicines affect the working of Macsita M 50/1000 Tablet 10?

Certain medications might interact with this tablet, affecting its efficacy or safety. Always inform your doctor about all other medicines you are taking.

Certified Content

Written by

Dr. Pauravi Abad

Medical Writer & Reviewer | 4 years

MBBS

Reviewed by

Dr. Osama Ahmed

Dental/Medical Writer, Editor, Reviewer | 2 years

Bachelor of Dental Surgery

Check out Editorial Policy

Manufacturer details

Atlanta Arcade, Marol Church Rd, Bori Colony, Vijay Nagar Colony West, Marol, Andheri East, Mumbai, Maharashtra 400059

Country of origin: INDIA

References

Website, N. (2024, January 23). Common questions about sitagliptin. nhs.uk. https://www.nhs.uk/medicines/sitagliptin/common-questions-about-sitagliptin/
U.S. National Library of Medicine. (2022). Metformin: MedlinePlus Drug Information. MedlinePlus. https://medlineplus.gov/druginfo/meds/a696005.html. Accessed on 1 April 2024.
Metformin: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB00331
U.S. National Library of Medicine. (2022). Sitagliptin: MedlinePlus Drug Information. MedlinePlus. https://medlineplus.gov/druginfo/meds/a606023.html. Accessed on 1 April 2024.
Sitagliptin: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB01261
Corcoran, C., & Jacobs, T. F. (2023, August 17). Metformin. StatPearls - NCBI Bookshelf. https://www.ncbi.nlm.nih.gov/books/NBK518983/

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