Lefra 10 Mg Tablet 10

Lefra 10 Tablet 10

Torrent Pharmaceuticals Ltd.

Strip of 10 Units

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Composition

Leflunomide (10 Mg)

Strength:

20 MG 10 MG

Lefra-10 Tablet is primarily used to manage active rheumatoid arthritis and active psoriatic arthritis in adults. This medication is part of the immunomodulatory agents group, specifically the isoxazole class.

In addition to its main use, this medicine can also help in reducing inflammation, joint pain, swelling and damage caused by these autoimmune conditions. It targets your immune system directly by suppressing its overactive responses.

Before you begin taking this medicine, it's crucial that you consult your doctor for the correct dosage and frequency. Make sure to inform your doctor about any pre-existing conditions or ongoing medications you may have. If you experience any side effects while on this medication, notify your doctor immediately. For the best results, continue taking the medicine for the duration prescribed by your doctor.

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Lefra-10 Tablet is used for the following conditions:

Managing active rheumatoid arthritis: This is a chronic inflammatory disorder that can affect more than just your joints. In some people, it can damage a wide variety of body systems, including the skin, eyes, lungs, heart and blood vessels.
Controlling active psoriatic arthritis: This condition causes inflammation of your joints and is closely linked with psoriasis, a skin condition. It typically leads to pain, stiffness and swelling in and around your joints.

Directions for Use of Lefra 10 Tablet 10

Here are the instructions to follow while taking Lefra-10 Tablet:

Follow the precise dosage and timing instructions provided by your doctor.
Do not change or exceed the prescribed dose without consulting your doctor.
Consult your doctor before discontinuing the medication; do not stop taking it without their guidance.
Adhere to the dietary recommendations given by your doctor.

Lefra-10 Tablet is taken orally.

Lefra-10 Tablet may cause the following side effects:

Diarrhoea
Alopecia: This is a condition in which you might experience hair loss.
Elevated liver enzymes: This could indicate potential damage to your liver.
Rash
Hypertension: This refers to high blood pressure, which can lead to serious heart problems if left unchecked.
Thrombocytopaenia: This is a condition that causes low platelet count in your blood, which could lead to bruising and slower clotting after an injury.

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing the use of Lefra-10 Tablet. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor. Here are some simple ways to manage a couple of common side effects:

Diarrhoea: Drink plenty of healthy fluids to stay hydrated and follow the diet recommended by your doctor.
Rash: Apply a cold compress to the affected area to reduce itching and inflammation. If the rash persists or worsens, consult your doctor.

Lefra-10 Tablet contains leflunomide (10 mg), which acts on your body in the following ways:

Inhibits Dihydroorotate Dehydrogenase: Leflunomide works by blocking your body's enzyme called dihydroorotate dehydrogenase. This enzyme plays a vital role in synthesising pyrimidine ribonucleotide uridine monophosphate (rUMP), which is required to grow and reproduce rapidly dividing cells.
Reduces Inflammation: By inhibiting this enzyme, leflunomide effectively interferes with the production of DNA and RNA, essential for rapidly dividing cells such as activated T lymphocytes involved in rheumatoid arthritis. This action reduces inflammation and helps manage symptoms.

Pregnancy

Lefra-10 Tablet is contraindicated during pregnancy. If you are expecting a baby or planning to conceive, it is crucial to discuss this with your doctor before starting this medicine.

Breastfeeding

This medicine is not recommended for breastfeeding women. It's important to consult your doctor to understand the potential risks and benefits.

Alcohol

Given this medicine's potential impact on the liver, it's wise to limit alcohol consumption while taking this medicine.

Liver

Caution is advised while taking Lefra-10 Tablet if you have mild to moderate liver impairment. It is not recommended for severe liver problems. If you have liver concerns, discuss them with your doctor before starting this medicine.

Kidney

Caution is advised if you have a history of kidney issues. Always consult your doctor before starting any new medication.

Using Machines & Driving

If you feel unwell or experience side effects that may affect your ability to concentrate, avoid these activities and consult your doctor.

Allergy

If you are allergic to leflunomide or any other ingredients in Lefra-10 Tablet, do not take this medicine. Discuss any known allergies with your doctor before starting treatment.

Children

This medicine is not typically prescribed for children under 18 years of age. Always consult your doctor regarding its use in younger patients.

Older Patients

Older patients should take Lefra-10 Tablet under medical supervision as they may be more susceptible to its side effects. Older individuals may also have liver and kidney issues and might be on other medication. Your doctor will guide you based on your health status.

Drug-Drug Interactions

Lefra-10 Tablet interacts with the following medicines:

Hepatotoxic medications: Medicines harmful to the liver, like paracetamol or ibuprofen, can increase the risk of liver damage when taken with Lefra-10 Tablet.
Immunosuppressants: Immunosuppressants such as azathioprine or ciclosporin can increase your risk of infections and bone marrow suppression when taken with Lefra-10 Tablet.
CYP2C8 substrates: These medicines, like repaglinide or paclitaxel, may have increased levels when taken with Lefra-10 Tablet.

Drug-Food Interactions

There is no specific food interaction with the Lefra-10 Tablet.

Drug-Disease Interactions

Lefra-10 Tablet interacts with the following diseases:

Liver Disease: If you have severe liver disease, taking Lefra-10 Tablet could worsen your condition.
Severe Immunodeficiency States such as AIDS: Taking Lefra-10 Tablet could further suppress your immune system, increasing your susceptibility to infections.
Severe Active Infection: If you have a severe infection, taking Lefra-10 Tablet could further suppress your immune system, making it harder for your body to fight the infection.
Hypertension: If you have high blood pressure, Lefra-10 Tablet may cause it to increase further.

Daily Dose

You should take the daily dose of Lefra-10 Tablet as directed by your doctor. Your dosage may vary depending on certain factors such as the severity of your symptoms and how you respond to the medicine. It's vital to take the medicine as prescribed. You must not increase your dosage without discussing it with your doctor.

Over Dose

If an overdose occurs, it could lead to common side effects like diarrhoea, rash, and hair loss. In case you suspect an overdose, inform your doctor promptly so that they can provide appropriate advice.

Missed Dose

If you forget to take your regular dose of Lefra-10 Tablet, take it as soon as you remember. If it's nearly time for your next dose, skip the missed one and continue with your regular schedule. Do not double your dosage to compensate for the missed dose without consulting your doctor.

Store Lefra-10 Tablet in a dry place, protected from light.
The ideal storage temperature is below 25°C.
Avoid exposing the tablet to excess moisture or heat.
Always keep this medicine out of reach of children.
Make sure to use the Lefra-10 Tablet before its expiry date.

Since Lefra-10 Tablet is used to manage rheumatoid and psoriatic arthritis, maintaining a balanced diet rich in fruits, vegetables, lean meats, and fish can be beneficial. These foods are rich in antioxidants that may help reduce inflammation.
Regular gentle exercise such as walking or swimming can help maintain joint flexibility and strength, potentially aiding in managing the symptoms of arthritis. Always consult your doctor for personalized advice.

Fact Box

Drug Category	Immunomodulatory agent
Therapeutic Category	Anti-rheumatic
Available Dosage Types	Tablet
Habit Forming	No
Ailment	Rheumatoid Arthritis, Psoriatic Arthritis

What is Lefra-10 Tablet used for?

Lefra-10 Tablet is used to manage active rheumatoid arthritis and psoriatic arthritis in adults by reducing inflammation, joint pain, and swelling.

How does Lefra-10 Tablet work?

It contains leflunomide, which hampers the growth of certain fast-dividing immune cells that contribute to inflammation in rheumatoid and psoriatic arthritis.

How should I take Lefra-10 Tablet?

You must take the medicine exactly as prescribed by your doctor.

What precautions should I take while taking Lefra-10 Tablet?

Regular blood tests to monitor liver function and blood counts are necessary. Women of childbearing age should use reliable contraception during and after treatment.

Can Lefra-10 Tablet interact with other medicines?

Yes, Lefra-10 Tablet can interact with certain medicines like warfarin, rifampin, hepatotoxic medicines and immunosuppressants. Always consult your doctor before starting any new medication.

What are the side effects of Lefra-10 Tablet?

Common side effects include diarrhoea, hair loss, elevated liver enzymes and rash. Less commonly, it may cause high blood pressure, headache and weight loss.

How should I store my Lefra-10 Tablets?

Store them below 25°C in a dry place away from light. Keep out of reach of children for safety.

Certified Content

Written by

Dr Nikita Lobo

Medical Editor & Reviewer | 7 years

BDS, MDS

Reviewed by

Dr. Chhavi Rosha

Health & Medical Content Writer | 8 years

BMS, FMC, MD Resident

Check out Editorial Policy

Manufacturer details

Torrent House, Off. Ashram Road, Ahmedabad - 380009, Gujarat, India

Country of origin: INDIA

References

Unknown, U. (2002). ARAVA tablets. In Unknown [Unknown]. https://www.accessdata.fda.gov/drugsatfda_docs/label/2003/20905slr007,20905se1-006_arava_lbl.pdf
ARAVA. (n.d.). ARAVA Tablets (leflunomide) 10 mg, 20 mg, 100 mg. https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/020905s022lbl.pdf
Padda, I. S., & Goyal, A. (2023, June 3). Leflunomide. StatPearls - NCBI Bookshelf. https://www.ncbi.nlm.nih.gov/books/NBK557799/
Leflunomide: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB01097
Leflunomide: MedlinePlus drug information. (n.d.). https://medlineplus.gov/druginfo/meds/a600032.html

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