Ivapace 5 Mg Tablet 10

Ivapace 5 Tablet 10

Corona

Strip of 10 Units

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Composition

Ivabradine (5 Mg)

Strength:

7.5 MG 5 MG

Ivapace 5 Tablet is primarily used for managing chronic stable angina pectoris in adults who are unable to tolerate or have a contraindication to beta-blockers. This medicine is part of the selective and specific inhibitors of the cardiac pacemaker.

In addition to the above primary use, this medicine also assists in the treatment of symptomatic chronic heart failure, particularly in patients with certain heart rate and rhythm conditions. It is also effective in managing stable symptomatic heart failure due to dilated cardiomyopathy in paediatric patients aged 6 months and older.

Before you start taking this medicine, it’s essential to inform your doctor about any pre-existing conditions or ongoing medications. If you observe any side effects, make sure to notify your doctor promptly. For maximum results, continue taking the medicine for the duration prescribed by your doctor.

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Ivapace 5 Tablet is used to manage the following health conditions:

Chronic stable angina pectoris in adults unable to use beta-blockers.
Chronic heart failure with systolic dysfunction in adults, where the heart rate is 75 bpm or more.
Stable heart failure due to dilated cardiomyopathy in children aged 6 months and older.

Directions for Use of Ivapace 5 Tablet 10

Taking Ivapace 5 Tablet correctly is crucial for it to work effectively. Here's how you should use it:

Swallow the tablet whole with a glass of water.
Avoid chewing or crushing the tablet.
Do not exceed the recommended dosage without your doctor's advice.
Remember, it's important not to stop taking this medicine without speaking to your doctor first.

Ivapace 5 Tablet is taken orally.

The following are some common side effects you may experience with Ivapace 5 Tablet:

Luminous phenomena (Phosphenes): This side effect may cause you to see bright, flashing lights that aren't actually there.
Blurred vision
Bradycardia: This means a slower-than-normal heart rate.
First-degree AV block: This is a minor disruption in the heart's electrical signals, which can cause a slow heartbeat.
Ventricular extrasystoles: This refers to extra heartbeats originating from the heart's lower chambers, or ventricles.
Dizziness
Headache
Uncontrolled blood pressure
Nausea
Diarrhoea
Constipation
Fatigue

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing the use of Ivapace 5 Tablet. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor. Here are some tips on managing certain side effects:

Bradycardia: If this medicine causes your heartbeat to slow down too much during the day, consider taking it at bedtime.
Diarrhoea: Try taking Ivapace 5 Tablet with food to lessen this effect.

Ivapace 5 Tablet contains ivabradine (5 mg), which works on the body in the following ways:

Inhibits HCN channel: Ivabradine blocks the hyperpolarization-activated cyclic nucleotide-gated (HCN) channel responsible for the cardiac pacemaker If current. This current controls spontaneous diastolic depolarisation in the sinus node, which is the heart's natural pacemaker.
Decreases heart rate: By inhibiting the If current, ivabradine effectively reduces the heart rate. It does so without influencing ventricular repolarisation or myocardial contractility, which means it doesn't affect the resetting of the heart's electrical activity or the heart muscle's ability to contract.

Pregnancy

Ivapace 5 Tablet should ideally be avoided during pregnancy unless absolutely necessary. Always consult your doctor before taking this medicine if you are pregnant.

Breastfeeding

Breastfeeding is not recommended when taking Ivapace 5 Tablet. Please discuss this with your doctor to understand the potential risks and benefits.

Alcohol

The interaction between alcohol and Ivapace 5 Tablet has not been extensively studied. It's best to consult your doctor for guidance.

Liver

Ivapace 5 Tablet is not recommended for people with severe liver diseases. If you have any liver problems, it's crucial to discuss them with your doctor before starting this medicine.

Kidney

While no dose adjustment is needed in mild to moderate kidney impairment, caution is advised if you have severe kidney problems. Consult your doctor before taking Ivapace 5 Tablet.

Using Machines & Driving

There are no known effects of Ivapace 5 Tablet on your ability to drive or operate machinery. However, if you feel dizzy or unwell after taking the medicine, avoid such tasks until you feel better.

Allergy

Ivapace 5 Tablet is contraindicated if you're allergic to ivabradine or any other ingredients in the medicine. If you're aware of any allergies, do discuss them with your doctor prior to starting the medicine.

Children

The safety and efficacy of Ivapace 5 Tablet have been established for children aged 6 months and older for the treatment of certain heart conditions. Always consult your doctor before giving this medicine to a child.

Older Patients

No dose adjustment is required for older patients using Ivapace 5 Tablet. However, as they may be more susceptible to side effects or may have liver and kidney issues, caution is advised. Your doctor will guide you based on your health status.

Drug-Drug Interactions

Ivapace 5 Tablet interacts with the following medicines:

Antifungals: Medicines such as ketoconazole, ritonavir, and clarithromycin may interact with Ivapace 5 Tablet and increase the level of ivabradine in the blood.
Anticonvulsants: When used alongside medicines like phenytoin, Ivapace 5 Tablet might have reduced efficacy due to decreased levels of ivabradine.
QT-prolonging medications: Medicines like amiodarone or sotalol can increase the risk of heart rhythm disorders when taken with Ivapace 5 Tablet.
Calcium channel blockers: If you're on medication such as verapamil or diltiazem that reduces heart rate, use caution while on Ivapace 5 Tablet.

Drug-Food Interactions

Ivapace 5 Tablet can interact with certain foods.

Grapefruit: Consuming grapefruit or grapefruit juice may increase the levels of ivabradine in your blood.

Drug-Disease Interactions

Ivapace 5 Tablet interacts with the following diseases:

Liver disease: If you have severe liver impairment, avoid taking Ivapace 5 Tablet as it could worsen your condition.
Hypotension: Individuals with low blood pressure should exercise caution while on this medicine as it could further reduce their blood pressure.
Cardiogenic shock and acute myocardial infarction: Patients suffering from cardiogenic shock or acute myocardial infarction should not take this medication.
Bradycardia: If your resting heart rate is below 60 bpm prior to treatment, do not use this medicine.
Atrial fibrillation: Regular monitoring is recommended if you have atrial fibrillation, since taking Ivapace 5 Tablet may increase its risk.

Daily Dose

The daily dose of Ivapace 5 Tablet should be taken as directed by your doctor. It's crucial to stick to the prescribed dosage, as it may vary based on your specific condition and how you respond to the medication. For more detailed instructions, please refer to the package insert.

Over Dose

An overdose of Ivapace 5 Tablet may lead to symptoms like a slower heart rate. If you suspect an overdose, inform your doctor. It's important not to exceed the recommended dosage without your doctor's advice.

Missed Dose

If you miss a dose of Ivapace 5 Tablet, take it as soon as you remember. However, if it's nearly time for your next dose, omit the missed one and carry on with your regular dosing schedule. Always consult your doctor before making any changes to the dosage.

Store Ivapace 5 Tablet in a cool, dry place, ideally at room temperature, which is typically below 25°C.
Keep the product away from direct sunlight to maintain its efficacy.
Ensure the Tablet is kept out of the reach and sight of children.
Consume the medicine before its expiry date as mentioned on the packaging.

If you're managing chronic heart failure or angina with Ivapace 5 Tablet, try to incorporate low-sodium foods in your diet. This can help reduce fluid retention and keep your heart functioning optimally.
Aim to do some light physical activities like walking or gentle cycling daily, unless advised otherwise by your doctor. Regular exercise can improve your heart health and overall wellbeing.

Fact Box

Drug Category	HCN Channel Inhibitor
Therapeutic Category	Cardiovascular Medicine
Available Dosage Types	Tablet
Habit Forming	No
Ailment	Chronic Stable Angina, Chronic Heart Failure

What is Ivapace 5 Tablet used for?

Ivapace 5 Tablet manages chronic stable angina, chronic heart failure in adults, and symptomatic heart failure due to dilated cardiomyopathy in children above 6 months.

How does Ivapace 5 Tablet work?

This medicine contains ivabradine, which lessens the heart rate by inhibiting a specific channel in the heart that controls the heart's rhythm without affecting heart muscle contraction.

Can I take Ivapace 5 Tablet with food?

You must take the medicine as directed by your doctor.

What should I do if I miss a dose of Ivapace 5 Tablet?

If you miss a dose, take it as soon as you remember. However, skip the missed dose if your next scheduled dose is close. Don't double dose.

Are there any side effects of Ivapace 5 Tablet?

Common side effects include light flashes (phosphenes), blurred vision, slower heartbeat, dizziness, headache, uncontrollable blood pressure, nausea, and fatigue.

Can Ivapace 5 Tablet be taken during pregnancy or while breastfeeding?

Unless absolutely necessary, Ivapace 5 Tablet should be avoided during pregnancy. Breastfeeding while taking this medicine is not recommended. Always consult your doctor.

How long does it take for Ivapace 5 Tablet to start working?

The maximum reduction in heart rate is generally achieved within 2 to 4 weeks of starting this medicine.

Certified Content

Written by

Dr Nikita Lobo

Medical Editor & Reviewer | 7 years

BDS, MDS

Reviewed by

Dr. Chhavi Rosha

Health & Medical Content Writer | 8 years

BMS, FMC, MD Resident

Check out Editorial Policy

Manufacturer details

Corona House, Block C, Mondeal Business Park,, S. G. Highway, Thaltej, near Gurudwara, Ahmedabad, 380059

Country of origin: INDIA

References

Amgen. (2015). HIGHLIGHTS OF PRESCRIBING INFORMATION [Prescribing information]. https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/209964lbl.pdf
VA Pharmacy Benefits Management Services, Medical Advisory Panel, and VISN Pharmacist Executives. (2015). Ivabradine Drug Monograph. https://www.pbm.va.gov/PBM/clinicalguidance/drugmonographs/Ivabradine_CORLANOR_Monograph.pdf
Ivabradine: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB09083
Fala, L. (2016, March 1). Corlanor (Ivabradine), First HCN Channel Blocker, FDA Approved for the Treatment of Patients with Heart Failure. PubMed Central (PMC). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5013853/
Tse, S., & Mazzola, N. (2015, December 1). Ivabradine (Corlanor) for heart failure: the first selective and specific if inhibitor. PubMed Central (PMC). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4671466/

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