Gufigest 400 Mg Tablet Sr 10

Gufigest 400 MG Tablet Sr 10

Gufic Bioscience Ltd

Pack of 10 Units

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MRP ~~₹585~~

₹479.7

₹58.50/Units

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Prescription required for this medicine

Store Below 30^o C

Composition

Natural Micronised Progesterone (400 Mg)

Strength:

400 MG 200 MG

Gufigest 400 MG Tablet Sr 10 is primarily used in hormone replacement therapy for women experiencing menopause symptoms. This medicine belongs to the group of medications known as progestogens.

In addition to this main use, it also serves various other purposes. It is used in the management of secondary amenorrhea, a condition characterised by absent menstrual periods. This medicine also assists in luteal phase support during assisted reproductive technology cycles. Furthermore, it aids in treating endometrial hyperplasia and prevents it from occurring in postmenopausal women undergoing estrogen therapy.

Before starting this medication, you should consult your doctor for appropriate dosage instructions. It is crucial to inform your doctor about any pre-existing conditions or current medications you are on. If you notice any side effects while taking this medicine, let your doctor know immediately. For best results, continue taking the medicine for as long as your doctor prescribes it.

Gufigest 400 MG Tablet Sr 10 is used in the following cases:

Helping with menopause-associated vasomotor symptoms and vulvovaginal atrophy
Managing secondary amenorrhea unrelated to pregnancy or primary ovarian failure
Assisting in luteal phase support in assisted reproductive technology cycles
Controlling endometrial hyperplasia
Preventing endometrial hyperplasia in postmenopausal women on oestrogen therapy
Managing dysfunctional uterine bleeding due to hormonal imbalance

Directions for Use of Gufigest 400 MG Tablet Sr 10

Swallow the tablet whole with a glass of water.
Do not chew, divide or crush the tablet.
Make sure not to exceed the recommended dose without consulting your doctor.

Gufigest 400 MG Tablet Sr 10 is taken orally.

Side Effects of Gufigest 400 MG Tablet Sr 10

The common side effects you might experience after taking Gufigest 400 MG Tablet Sr 10 include:

Abdominal pain or discomfort
Back pain
Breast tenderness
Dizziness
Nausea
Vomiting
Vaginal discharge
Joint pain: This refers to any discomfort, aches, and soreness in any of the joints in your body.
Mood changes: This could include feelings of depression or irritability.
Bloating: This condition makes your stomach feel full and tight due to gas in the digestive system.
Oedema: This is swelling caused by excess fluid trapped in your body's tissues.

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing the use of Gufigest 400 MG Tablet Sr 10. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are some tips for managing common side effects:

Nausea and vomiting: Taking Gufigest 400 MG Tablet Sr 10 after meals may help lessen this effect.
Abdominal pain or discomfort: Consider taking this medicine at night if it causes you abdominal discomfort during the day.

Gufigest 400 MG Tablet Sr 10 contains progesterone (400 mg). This component works on your body through the following actions:

Transformation of Endometrium: Progesterone turns the lining of your uterus from a proliferative phase to a secretory phase. In simpler terms, it prepares the uterus for pregnancy.
Maintenance of Pregnancy: It supports uterine quiescence, which means it helps keep the uterus calm and prevents contractions that could lead to miscarriage.
Mammary Glands Development: Progesterone promotes the growth and development of mammary glands that produce milk.
Anti-Estrogenic Effects: It has antiestrogenic effects on the uterine lining, which means it counteracts the effects of estrogen.
Regulating Gonadotropin Secretion: The hormone also regulates gonadotropin secretion through negative feedback on the hypothalamic-pituitary-gonadal axis. This means it helps control the release of other hormones that play a part in female reproductive processes.

Pregnancy

Caution is advised while taking Gufigest 400 MG Tablet Sr 10 if you are pregnant. It is best to consult your doctor before taking this medicine.

Breastfeeding

This medicine may pass into breast milk in small amounts. While it's unlikely to harm your baby, it's always wise to consult your doctor before taking Gufigest 400 MG Tablet Sr 10 while breastfeeding.

Alcohol

Caution is advised when consuming alcohol if this medication is prescribed to you, as alcohol can affect the levels of progesterone.

Liver

If you have a history of liver problems, caution is advised before using Gufigest 400 MG Tablet Sr 10. Consult your doctor, especially if you have severe liver disease.

Kidney

If you have kidney health issues, it's advised to consult your doctor before using Gufigest 400 MG Tablet Sr 10.

Using Machines & Driving

Gufigest 400 MG Tablet Sr 10 may cause dizziness or sleepiness. If you feel affected, avoid driving or operating heavy machinery until you feel well again.

Allergy

If you're allergic to progesterone or any other ingredients in Gufigest 400 MG Tablet Sr 10, avoid using this medication. Always inform your doctor about any allergies you have.

Children

Gufigest 400 MG Tablet Sr 10 is not meant for use in children. Always consult your doctor before giving any medicine to a child.

Older Patients

Older patients should take Gufigest 400 MG Tablet Sr 10 under medical supervision as they may be more susceptible to its side effects. Caution is advised if patients are over 70 years of age. Your doctor will guide you based on your health status.

Interactions of Gufigest 400 MG Tablet Sr 10

Drug-Drug Interactions

Gufigest 400 MG Tablet Sr 10 interacts with the following medicines:

CYP3A4 inducers: Medicines like rifampin, carbamazepine, phenytoin, and phenobarbital may reduce the effectiveness of Gufigest 400 MG Tablet Sr 10, as they decrease the progesterone concentrations. Regular monitoring and possible dose adjustments might be necessary.
CYP3A4 inhibitors: Medications including ketoconazole and clarithromycin can increase the progesterone levels in your body when taken with Gufigest 400 MG Tablet Sr 10. Use these medicines with caution to avoid potential side effects.

Drug-Food Interactions

Grapefruit Juice: It may interact with progesterone and increase its levels.

Drug-Disease Interactions

Gufigest 400 MG Tablet Sr 10 interacts with the following diseases:

Cardiovascular disorders: If you have any cardiovascular conditions, use Gufigest 400 MG Tablet Sr 10 carefully, as it may cause fluid retention, which can worsen such conditions.
Breast cancer: Gufigest 400 MG Tablet Sr 10 should be used cautiously if you have breast cancer or other progestin-sensitive cancers.
Liver disease: If you suffer from severe liver dysfunction or disease, avoid using this medicine as it undergoes extensive metabolism in the liver.

Daily Dose

The daily dose of Gufigest 400 MG Tablet Sr 10 should be taken as directed by your doctor. Your dosage may vary based on individual factors, such as the severity of your condition and your response to the medicine. Always follow the prescribed dosage and never exceed it without consulting your doctor. For further details regarding the dosage, read the package insert.

Over Dose

In case of an overdose, you might experience symptoms like drowsiness, dizziness, or mild mood changes. Avoid panicking and consult your doctor if these symptoms persist or worsen.

Missed Dose

If you forget to take Gufigest 400 MG Tablet Sr 10 at the usual time, take it as soon as you remember. However, if it's nearly time for your next dose, skip the missed one and continue with your regular schedule. Never increase your dosage without consulting your doctor.

Store Gufigest 400 MG Tablet Sr 10 in a dry place, ideally below 30°C.
Guard it from exposure to light.
Always keep this medicine out of reach of children.
Be sure to consume the tablet before its expiry date.

For those managing symptoms associated with menopause, maintaining a balanced diet rich in calcium and Vitamin D can help support bone health.
Regular physical activity such as walking or yoga can help reduce discomfort from vasomotor symptoms like hot flushes and night sweats.

Fact Box

Drug Category	Progesterone Receptor Agonist
Therapeutic Category	Hormone Supplement
Available Dosage Types	Sustained-Release Tablet
Habit Forming	No
Ailment	Secondary Amenorrhoea, Menopause Symptoms, Endometrial Hyperplasia

What is Gufigest 400 MG Tablet Sr 10 used for?

It's used to manage conditions related to progesterone deficiency, including menopause-related symptoms and secondary amenorrhea.

How does Gufigest 400 MG Tablet Sr 10 work?

It contains progesterone that binds to receptors in tissues like the uterus, aiding in maintaining pregnancy and transforming the uterus lining.

Can I take Gufigest 400 MG Tablet Sr 10 with food?

Yes, you can take it with or without food. Consuming it with food might enhance its absorption. Consult your doctor.

How should I take Gufigest 400 MG Tablet Sr 10?

Swallow the tablet whole without chewing, dividing or crushing it. Follow your doctor's advice.

What are the contraindications of Gufigest 400 MG Tablet Sr 10?

Avoid use if you're pregnant, have undiagnosed vaginal bleeding, severe liver disease, active thromboembolic disease, or known progesterone sensitivity.

Are there any side effects of Gufigest 400 MG Tablet Sr 10?

Common side effects include abdominal discomfort, back pain, breast tenderness, headaches, mood changes, and bloating. Consult your doctor if these persist or worsen.

Can I use Gufigest 400 MG Tablet Sr 10 during pregnancy and lactation?

It is a pregnancy category B medicine; use only if needed. Caution is advised during lactation as progesterone enters breast milk.

Certified Content

Written by

Dr Nikita Lobo

Medical Editor & Reviewer | 7 years

BDS, MDS

Reviewed by

Dr. Divya Chauhan

Medical Writer & Reviewer | 6 years

BAMS, APG, PG

Check out Editorial Policy

Manufacturer details

37,1st Floor, Kamala Bhavan II, Swami Nityanand Road, Andheri (East), Mumbai – 400 069. (INDIA)

Country of origin: INDIA

References

Shah, D., Nagarajan, N., Goud, A., & Muralidhar, S. (2016). Role of progesterone in the treatment of high-risk pregnancy and prevention of preterm labour. Biomedicine & Pharmacotherapy, 78, 104-110. Retrieved April 1, 2024, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4800604/
Progesterone and derivatives. (n.d.). DrugBank Online | Database for Drug and Drug Target Info. https://go.drugbank.com/categories/DBCAT000992
Serum progesterone: MedlinePlus medical encyclopedia. (n.d.). MedlinePlus - Health Information from the National Library of Medicine. https://medlineplus.gov/ency/article/003714.htm
US Food and Drug Administration. (n.d.). Prometrium Label. https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/019781s013lbl.pdf
PubChem. (n.d.). Progesterone. https://pubchem.ncbi.nlm.nih.gov/compound/Progesterone

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We, at Truemeds make a diligent attempt to deliver accurate, expert- drafted and thoroughly reviewed medicine related information to our consumers. However, it should, by no means, be considered a substitute for prescription from a certified doctor or a trustworthy doctor-patient relationship. In fact we detest any form of self medication without expert advice. The sole purpose of the information on our portal is to educate our consumers, which helps improve the communication between a doctor and a patient. The information by no means is complete in its entirety and should not be used to diagnose or treat any medical condition. No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately.

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