Doriglen 500 Mg Injection 1

Doriglen Injection 1

Glenmark Pharmaceuticals Ltd.

Vial of 1 Units

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MRP ~~₹4437.5~~

₹3638.75

₹4437.50/Units

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Composition

Doripenem (500 Mg)

Doriglen Injection 1 is primarily used to manage serious bacterial infections in adults. Belonging to the class of carbapenem antibiotics, it is potent against a wide range of bacteria, making it an effective choice for tackling stubborn infections.

This injection is also used to manage complicated intraabdominal infections and complicated urinary tract infections, including pyelonephritis, a type of kidney infection. However, it's important to remember that this antibiotic doesn't work against colds, flu, or other viral infections.

You should administer this medicine as directed by your doctor. Before starting the medication, make sure to inform your doctor about any preexisting medical conditions or ongoing medications you might be taking. If you notice any side effects while on this medicine, promptly notify your doctor. Continue administering the injection for the duration prescribed by your doctor for the best results.

Doriglen Injection 1 is typically used for the following health conditions:

Management of complicated intraabdominal infections
Management of complex urinary tract infections, including pyelonephritis (kidney infection)
Please note that this medicine is not designed to handle colds, flu or other viral infections. It is effective against infections caused by susceptible bacteria.

Directions for Use of Doriglen Injection 1

The injection should be given by a healthcare professional in a hospital setting.
Always follow your doctor's advice on the duration of the treatment course.

Doriglen Injection 1 is administered intravenously.

The use of Doriglen Injection 1 may lead to the following common side effects:

Headache
Nausea
Diarrhoea
Rash
Phlebitis or inflammation of the veins

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing the use of Doriglen Injection 1. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are some simple guidelines to manage common side effects:

Nausea: Follow dietary guidelines advised by your doctor.
Diarrhoea: Consider taking plenty of fluids to stay hydrated and avoid dehydration caused by diarrhoea.

Doriglen Injection 1 contains Doripenem (500 mg). This ingredient works on your body through the following mechanisms:

Inhibiting Bacterial Cell Wall Synthesis: Doripenem works by obstructing the synthesis of bacterial cell walls. In simple terms, it hampers the creation of a protective layer around bacterial cells.
Causing Cell Death: By inhibiting cell wall synthesis, doripenem causes the bacterial cells to die. This process helps in managing bacterial infections effectively.

Pregnancy

If you are pregnant or planning to become pregnant, caution is advised while taking Doriglen Injection 1. It is best to consult your doctor before taking this medicine.

Breastfeeding

Doriglen Injection 1 is administered during breastfeeding with caution as doripenem, its active ingredient, is excreted in breast milk. It's recommended to discuss the potential risks and benefits with your doctor.

Alcohol

There are no specific guidelines on the consumption of alcohol while using Doriglen Injection 1. However, it's always wise to consult your doctor for any concerns.

Liver

Caution is advised while taking Doriglen Injection 1 if you have a history of liver health issues. Discuss any liver-related concerns with your doctor before starting this medicine.

Kidney

Dosage adjustments of Doriglen Injection 1 are required for patients with impaired renal function. Therefore, if you have a history of kidney health issues, it's advisable to consult your doctor before taking this medicine.

Using Machines & Driving

No specific precautions are available regarding using heavy machinery or driving while using Doriglen Injection 1. However, it's always safe to discuss any concerns with your doctor.

Allergy

Doriglen Injection 1 is contraindicated for those having known serious hypersensitivity to doripenem or other medicines in the carbapenem class. Alert your doctor about any allergies before you start using this medicine.

Children

It may not be safe to give Doriglen Injection 1 in patients under 18 years of age without a doctor's guidance. Consult your doctor before giving this medicine to a child.

Older Patients

Older patients should administer Doriglen Injection 1 under medical supervision as they may be more susceptible to its side effects due to potential age-related renal impairment. Your doctor will guide you based on your health status.

Drug-Drug Interactions

Doriglen Injection 1 interacts with the following medicines:

Antibiotics: Antibiotics such as gentamicin may interact with doripenem, potentially increasing the risk of nephrotoxicity.
Anticoagulants: Medicines like warfarin may interact with doripenem, potentially increasing the risk of bleeding.
Uricosuric agents: Probenecid can inhibit the renal excretion of doripenem, increasing its levels in the blood and potentially enhancing its side effects.

Drug-Food Interactions

There are no specific foods known to interact with Doriglen Injection 1.

Drug-Disease Interactions

Doriglen Injection 1 interacts with the following diseases:

Kidney Disease: Patients with kidney impairment may require dosage adjustments due to their reduced ability to clear doripenem from the body.
Seizure Disorders: Those with a history of seizures or strokes are at a higher risk of experiencing seizures when using this medicine due to its potential neurological effects.
Allergies: Individuals allergic to doripenem, carbapenems, penicillins, cephalosporins, or beta-lactams should avoid this medicine due to the increased risk of serious hypersensitivity reactions.

Daily Dose

Your doctor will prescribe the daily dose of Doriglen Injection 1, considering your individual health conditions and response to the medicine. It's crucial to adhere to this prescribed dosage without any modification unless your doctor advises otherwise.

Over Dose

An overdose is highly unlikely for this medication as it is administered by a skilled healthcare professional.

Missed Dose

If you forget to have a dose of Doriglen Injection 1 as scheduled, consult with your doctor for advice.

Store Doriglen Injection 1 in the original packaging.
Keep it away from direct light.
Ensure the product is out of reach of children.
Always check the expiry date before use.

If you're managing complicated intra-abdominal infections, maintain a balanced diet with plenty of fibre to support your gut health.
For those with complicated urinary tract infections, including kidney infections, ensure an adequate water intake to help cleanse your urinary system.

Fact Box

Drug Category	Antibacterial
Therapeutic Category	Antibiotic
Available Dosage Types	Injection
Habit Forming	No
Ailment	Complicated Intra-abdominal Infections, Complicated Urinary Tract Infections, Pyelonephritis

What is Doriglen Injection 1 used for?

It's administered to manage complicated bacterial infections in the stomach area and urinary tract, including kidney infections.

How does Doriglen Injection 1 work?

It works by stopping bacteria from building their cell walls, causing them to die. This helps control the infection.

Can I use Doriglen Injection 1 for a common cold or flu?

No, this medicine only manages bacterial infections and won't work on colds, flu, or any viral infections.

What are the common side effects of Doriglen Injection 1?

You may experience headache, nausea, diarrhoea, skin rash or inflammation of veins after taking this injection. Consult your doctor if these persist.

Are there any precautions I need to take before using Doriglen Injection 1?

Inform your doctor about allergies, current medications, medical history, including seizure disorders, strokes, or kidney diseases, pregnancy or breastfeeding status.

Can Doriglen Injection 1 interact with other medicines?

Yes, it can interact with probenecid and valproic acid/sodium valproate. Always consult your doctor before starting any new medication.

How should I store my Doriglen Injection 1?

Store this injection away from light. Once reconstituted, it's stable for 12 hours at room temperature or 72 hours refrigerated.

Certified Content

Written by

Dr. Michelle Frank

Medical Content Writer | 8 years

Doctor of Medicine

Reviewed by

Dr. Chhavi Rosha

Health & Medical Content Writer | 8 years

BMS, FMC, MD Resident

Check out Editorial Policy

Manufacturer details

Glenmark House, HDO-Corporate Building, Wing-A, B.D. Sawant Marg, Chakala Off. Western Express Highway, Andheri (East), Mumbai, Maharashtra, 400099 India

Country of origin: INDIA

References

DORIBAX® (doripenem for injection). (N.d.). Fda.Gov. Retrieved August 21, 2024, from
https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/022106s008lbl.pdf
DORIBAX (doripenem) Powder. (N.d.). Fda.Gov. Retrieved August 21, 2024, from
https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/022106s002s005lbl.pdf
Doribax 500 mg powder for solution for infusion. (n.d.). In SUMMARY OF PRODUCT CHARACTERISTICS. https://ec.europa.eu/health/documents/community-register/2009/2009071460071/anx_60071_en.pdf
Janssen Inc. (2013). DORIBAX. https://pdf.hres.ca/dpd_pm/00020914.PDF
Doripenem: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB06211

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