Domin 40 Mg Injection 5 Ml

Domin 40mg Injection 5ml

Neon Laboratories Ltd

Ampoule of 5 ML

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MRP ~~₹32.1~~

₹26.32

₹6.42/ML

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Composition

Dopamine (40 Mg)

Domin Injection is primarily used to manage critically low blood pressure (hypotension) and shock arising from various conditions such as severe infections (sepsis), heart attacks, heart surgeries, or traumas. This medication falls under the class of sympathomimetic amines, specifically functioning as a vasopressor.

In addition to managing hypotension, it is beneficial in heart and kidney failure situations. It improves blood pressure, thereby helping the body regain stability.

Before starting this injection, it is important to consult your doctor about the right dosage and frequency. Always inform your doctor about any other medications you're taking or any pre-existing conditions you have. If you notice any side effects while on this medicine, notify your doctor immediately. For optimal results, continue using the medication for the duration prescribed by your doctor.

Domin Injection is used to manage the following health conditions:

Hypotension associated with severe infections (sepsis), heart attacks, heart failure, or kidney failure
Shock resulting from severe trauma
Complications that arise from heart surgeries like open-heart surgery

Directions for Use of Domin 40mg Injection 5ml

Domin Injection should be given as a continuous intravenous (IV) infusion, ideally in a hospital setting.
The medicine should be administered in the dosage and frequency prescribed by your doctor.
The administered dose should be closely monitored and adjusted based on the patient's blood pressure response.
It is important to correct any fluid loss in your body before starting this medicine.
If you need to stop using this medicine, consult your doctor for specific directions.

Domin Injection is administered intravenously.

Side Effects of Domin 40mg Injection 5ml

Domin Injection may have the following common side effects:

Nausea and vomiting
Flushing (your face may appear warm and red)
Headache
Anxiety
Palpitations or rapid heartbeats

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve upon discontinuing the medicine. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

You can also effectively manage common side effects like headaches by giving gentle head massages or taking rest.

Domin Injection contains dopamine hydrochloride (40 mg) as the active ingredient. It works in the human body in the following manner:

Dopamine hydrochloride stimulates
your heart to contract intensely, enhancing cardiac output.
It also constricts blood vessels (vasoconstriction), which, in turn, increases blood pressure.

Pregnancy

Caution is advised while administering Domin Injection if you are pregnant. It is best to consult your doctor before using this medicine.

Breastfeeding

Exercise caution when administering this medicine to nursing mothers as dopamine hydrochloride may pass into breast milk and affect the baby. Always consult your doctor before starting this medicine.

Alcohol

It's always a good idea to avoid alcohol intake while on any medication to prevent any unwanted side effects. Always consult your doctor regarding alcohol consumption.

Liver

As patients with liver health issues may have altered metabolism, caution is advised when administering Domin Injection if you have liver problems. Always consult your doctor before starting this medication.

Kidney

Caution should be exercised while administering this injection if you have existing kidney health issues. Your doctor will guide you based on your health status.

Using Machines & Driving

Domin Injection is not known to affect your ability to drive or operate machinery. However, if you feel unwell or dizzy after using the medicine, avoid doing such activities until you feel better.

Allergy

This medicine is contraindicated if you are hypersensitive or allergic to dopamine hydrochloride or any other ingredients in the formulation. Always discuss your allergies with your doctor.

Children

The injection should be administered to children only under medical supervision. Always consult your doctor before giving any medicine to a child.

Older Patients

Older patients should be administered this injection under medical supervision as they may be more susceptible to its side effects. Caution is advised if patients are above 70 years of age as they might also have liver and kidney issues and might be on other medication. Your doctor will guide you based on your health status.

Interactions of Domin 40mg Injection 5ml

Drug-Drug Interactions

Domin Injection may interact with the following medications:

Monoamine oxidase inhibitors (MAOIs): Medicines such as phenelzine or selegiline, when taken with Domin Injection, can lead to a sudden and significant increase in blood pressure, leading to a hypertensive crisis.
Tricyclic antidepressants: Medications like amitriptyline or nortriptyline may amplify the blood pressure, increasing the effects of this injection.
Other vasopressors: Other blood pressure-increasing medicines like norepinephrine or phenylephrine can increase the hypertensive effect of Domin Injection.
Anaesthetics: Halogenated anaesthetics, such as isoflurane and sevoflurane, can increase the risk of irregular heartbeat when used with medicine.

Drug-Food Interactions

Domin Injection may interact with certain foods, such as:

Tyramine-rich foods: Foods high in tyramine, such as aged cheese and smoked meats, can potentially increase blood pressure when consumed alongside the medicine.
High-sodium foods: Foods like processed cheese and seafood are high in sodium and can further alleviate your blood pressure levels when taken with dopamine hydrochloride.

Drug-Disease Interactions

Domin Injection may interact with the following diseases:

Hypertension: In patients already having high blood pressure, Domin Injection can worsen their condition by further increasing blood pressure levels.
Pheochromocytoma: This medicine is contraindicated in patients suffering from pheochromocytoma, a catecholamine-secreting tumour, as it can worsen their condition.
Occlusive vascular diseases: Patients with blocked arteries should use this medication cautiously as it may further reduce blood supply to affected areas.

Daily Dose

Your doctor will determine the precise daily dosage of Domin Injection, considering factors like the severity of your condition and response to treatment. Refer to the package insert for specific dosage instructions.

Over Dose

If an accidental overdose of Domin Injection occurs, you might experience symptoms like nausea, headache, or rapid heartbeats. If these symptoms persist, consult your doctor.

Missed Dose

If you miss a dose of this injection, get it administered as soon as you remember. However, if it's nearly time for the next dose, consult your doctor for the next schedule of dosage.

Store Domin Injection in a cool, dry place where the temperature stays below 30°C.
Protect this medicine from light; it's not meant to be frozen.
Ensure that children cannot reach the stored injection.
Always check the expiry date before use. Discard any opened vials that aren't used immediately.

If you're managing heart-related conditions, try following a low-sodium diet to maintain healthy blood pressure levels.
To improve cardiovascular health, engage in regular, moderate-intensity exercises like walking or cycling. However, always consult your doctor before starting any new exercise regime.

Fact Box

Drug Category	Vasopressor
Therapeutic Category	Cardiovascular Agent
Available Dosage Types	Injection
Habit Forming	No
Ailment	Shock, hypotension

What does Domin Injection do?

Domin Injection manages events like shock and critically low blood pressure arising from conditions like heart attack, trauma, severe infection, open heart surgery, or kidney failure.

How does Domin Injection work?

This medicine works by stimulating your heart to contract intensely and constricting your blood vessels, thereby raising your blood pressure.

How is Domin Injection administered?

Domin Injection is administered as a continuous intravenous infusion in a hospital setting. It is given under close monitoring by medical professionals.

Are there any contraindications for Domin Injection?

Yes, it should not be used in patients with pheochromocytoma (a tumour that secretes catecholamines), certain arrhythmias, or if you're allergic to dopamine hydrochloride or other excipients. Always consult your doctor before starting this medicine.

What precautions should I take when using Domin Injection?

Ensure hypovolaemia (low blood volume) is corrected before starting dopamine hydrochloride. Also, monitor for signs of leakage and ischaemia during administration.

What are the side effects of Domin Injection?

The common side effects of this medicine include increased heart rate, headaches, anxiety, and nausea. If these symptoms persist, consult your doctor immediately

Can pregnant or nursing women use Domin Injection?

This injection should be administered in pregnant and nursing women only if needed. Always consult your doctor before using this medicine.

Certified Content

Written by

Ashmita Borgohain

Medical Content Writer & Editor | 12 years

MSc (Applied Genetics)

Reviewed by

Dr. Meenakshi Maruwada

Medical Content Writer & Strategist | 8 years

BDS, PGCAD, GMHE (IIM-B)

Check out Editorial Policy

Manufacturer details

140, Damji Samji Industrial Complex, Mahakali Caves Rd, Andheri(East), Mumbai, Maharashtra 400093

Country of origin: INDIA

References

Hospira, Inc., (2021, April). DOPAMINE HYDROCHLORIDE IN DEXTROSE injection, for intravenous use. https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/018826s047lbl.pdf
Dopamine. (n.d.). DrugBank Online | Database for Drug and Drug Target Info. https://go.drugbank.com/drugs/DB00988
National Library of Medicine. (n.d.). Dopamine hydrochloride. PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/65340
Sonne J, Goyal A, Lopez-Ojeda W. (2023, July 3). Dopamine - StatPearls - NCBI bookshelf. National Center for Biotechnology Information. https://www.ncbi.nlm.nih.gov/books/NBK535451/
Backer, D., Biston, P., Devriendt, J., Madl, C., Chochrad, D., Brasseur, A., Aldecoa, C., Defrance, P., Gottignies, P., & Vincent, J. (2010). Comparison of Dopamine and Norepinephrine in the Treatment of Shock. The New England Journal of Medicine. https://doi.org/10.3410/f.2302993.3227061

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