Divaa Od 500 Mg Tablet Er 10

Divaa Od 500 Tablet 10

Intas Pharmaceuticals Ltd

Strip of 10 Units

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MRP ~~₹181.5~~

₹148.83

₹18.15/Units

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Composition

Divalproex (500 Mg)

Strength:

750 MG 250 MG 500 MG 125 MG 1000 MG

Divaa-OD 500 Tablet is primarily used to manage epilepsy, a neurological condition that causes frequent seizures. This medication belongs to a class of medicines known as valproates.

In addition to managing epilepsy, this medicine can also be used to manage bipolar disorder, a psychiatric condition marked by extreme mood swings. Additionally, it is used in the prevention of migraines, which are severe headaches often accompanied by nausea and light sensitivity.

Before starting this medicine, you should consult your doctor for the correct dosage and frequency. Let your doctor know about any pre-existing conditions or other medications you are currently taking. If you notice any side effects while on this medicine, inform your doctor immediately. It's critical to continue taking this medicine for the duration prescribed by your doctor for optimal results.

Divaa-OD 500 Tablet is used for the management of the following conditions:

Seizure control in epilepsy patients
Stabilising mood swings in bipolar disorder
Preventing the occurrence of migraines

Directions for Use of Divaa Od 500 Tablet 10

Here's how to take Divaa-OD 500 Tablet:

Check the expiration date while buying the medicine.
Always stick to your doctor's recommended dosage.
Never stop taking this medicine without consulting your doctor.

The Divaa-OD 500 Tablet is taken orally.

Divaa-OD 500 Tablet may cause the following side effects:

Nausea
Vomiting
Diarrhoea
Abdominal pain
Drowsiness
Dizziness
Tremors
Thrombocytopaenia (low platelet count in your blood)
Hyponatraemia (low levels of sodium in your blood)

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve upon discontinuing the use of Divaa-OD 500 Tablet. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are some general guidelines for managing and avoiding common side effects:

Nausea or vomiting: Stick to the diet recommended by your doctor to avoid these problems.
Drowsiness or dizziness: If you suffer from severe drowsiness throughout the day after taking the medicine, seek advice from your doctor.

Divaa-OD 500 Tablet contains Divalproex (500 mg) and works in the following ways:

Increases GABA Levels: Divalproex enhances the activity of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter that reduces the electrical activity in neurons or nerve cells. By increasing GABA levels, it calms overactive neurons and helps prevent seizures.
Sodium Channel Blockade: Divalproex blocks channels that allow sodium ions to pass through the cell membranes of neurons. These channels are crucial for generating and propagating electrical impulses in nerve cells. Blocking these channels contributes to the anticonvulsant and mood-stabilizing properties of Divaa-OD 500 Tablet.
Histone Deacetylase Inhibition: Divalproex has been shown to inhibit enzymes called histone deacetylases. These enzymes play a role in gene expression and neuron plasticity, which involves changes in neuron connections and functions over time. This inhibition may contribute to the long-term therapeutic effects of Divaa-OD 500 Tablet in managing epilepsy and bipolar disorder.

Pregnancy

Divaa-OD 500 Tablet may pose a risk to your unborn child, particularly relating to neural tube defects. Always consult your doctor if you are pregnant or planning to conceive.

Breastfeeding

Caution is advised if you are currently nursing your baby. Discuss with your doctor the potential risks and benefits of taking this medicine while breastfeeding.

Alcohol

Avoid alcohol consumption while taking the Divaa-OD 500 Tablet as it may amplify the risk of side effects.

Liver

If you have any liver problems, use Divaa-OD 500 Tablet with caution. This medicine could affect liver function and is not recommended if you have severe liver diseases.

Kidney

If you have any kidney-related health issues, it's important to consult your doctor before you start taking the Divaa-OD 500 Tablet.

Using Machines & Driving

Divaa-OD 500 Tablet can cause drowsiness or dizziness. If you experience such side effects, avoid driving or operating heavy machinery until you feel normal again.

Allergy

Do not take Divaa-OD 500 Tablet if you are allergic to divalproex, which is a prominent ingredient in this medicine.

Children

Caution is advised when giving Divaa-OD 500 Tablets to children under 18 years of age. Always consult a doctor before giving this medicine to a child.

Older Patients

If you are an older patient, use Divaa-OD 500 Tablet with medical supervision, as you may be more susceptible to its side effects. Your doctor will guide you based on your health status.

Drug-Drug Interactions

Divaa-OD 500 Tablet interacts with the following medicines:

Carbapenem Antibiotics: Medicines like imipenem or meropenem can reduce the effectiveness of this medication.
Oral Contraceptives: This medicine may reduce the effectiveness of hormonal birth control pills.
Anticonvulsants like Phenobarbital and Phenytoin: These medications can lower divalproex levels in your body, which might reduce its effectiveness.

Drug-Food Interactions

There are no food interactions. However, maintain your diet as recommended by your doctor to avoid side effects.

Drug-Disease Interactions

Divaa-OD 500 Tablet interacts with the following diseases:

Liver Disease: If you have liver problems, this medicine could worsen your condition.
Pregnancy: Divalproex may harm the unborn baby, especially by causing neural tube defects.
Blood Disorders: If you have any blood disorders, this medicine might decrease your platelet count further.
Mitochondrial Disease: People with underlying mitochondrial diseases may experience liver failure when using this medication.

Daily Dose

The daily dose of Divaa-OD 500 Tablet should be taken as directed by your doctor. The exact dosage may vary based on individual factors, such as the severity of your condition and how you respond to the medicine. It's crucial to stick to the prescribed dosage and never exceed it without consulting your doctor.

Over Dose

If you happen to take more than the prescribed dosage, you might experience some overdose symptoms like drowsiness or stomach upset. In such cases, inform your doctor about the situation.

Missed Dose

If you've missed a dose of Divaa-OD 500 Tablet, take it as soon as you remember. However, if it's close to the time for your next dose, skip the missed one and continue with your regular schedule. Refrain from increasing your dosage without discussing it with your doctor.

Keep Divaa-OD 500 Tablet in its original packaging to protect it from light and moisture.
Store at room temperature between 15 and 30°C.
Always keep this medicine out of reach of children.
Check the expiry date on the pack and don't use the tablet if it's past this date.

If you are taking Divaa-OD 500 Tablet for managing epilepsy, try adopting a balanced diet that includes plenty of fruits, vegetables, and whole grains. This can help boost overall brain health.
For those using the tablet for bipolar disorder, regular physical activity has been found beneficial. Moderate exercise, like walking or cycling, could help manage mood fluctuations. Always consult your doctor before starting any new exercise regime.

Fact Box

Drug Category	Sodium Channel Blocker
Therapeutic Category	Anticonvulsant
Available Dosage Types	Tablet
Habit Forming	No
Ailment	Epilepsy, Bipolar Disorder, Migraine Prevention

What is Divaa-OD 500 Tablet used for?

Divaa-OD 500 Tablet is a medication used to manage neurological and psychiatric conditions such as epilepsy, and bipolar disorder, and to prevent migraines.

How does the Divaa-OD 500 Tablet work

This tablet works by controlling the activity of neurotransmitters in your brain, which helps to reduce seizures, stabilise mood, and prevent migraines.

Can I take Divaa-OD 500 Tablet with food?

Consume the tablet exactly as prescribed by your doctor.

What are some side effects of Divaa-OD 500 Tablet?

Common side effects may include nausea, dizziness, tremors and weight gain. If these conditions persist or worsen, consult your doctor immediately.

Are there any precautions to take while using Divaa-OD 500 Tablet?

Yes, the medicine should be used with caution if you're pregnant or have liver disease or blood disorders. Always consult your doctor before use.

Can Divaa-OD 500 Tablet interact with other medicines?

Yes, it can interact with medicines like oral contraceptives and anticonvulsants among others. Always inform your doctor about all other medications you're taking.

How should I store my Divaa-OD 500 Tablet?

Store the medicine at room temperature in a tight container out of reach from children and pets. Dispose of expired tablets as per local regulations.

Certified Content

Written by

Dr. Sachin Singh

Medical Team Lead | 5 years

MBBS

Reviewed by

Dr. Mandeep Chadha

Lead Medical Content Reviewer | 10 years

MBBS, DNB (OBGY)

Check out Editorial Policy

Manufacturer details

Corporate House, Near Sola Bridge, S. G. Highway, Thaltej, Ahmedabad 380054, Gujarat, India

Country of origin: INDIA

References

Dailymed. (n.d.). DIVALPROEX SODIUM tablet, extended release [Teva Pharmaceuticals USA, Inc.]. Retrieved 1 April 2024, from https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=b367d81d-4eca-4e28-b490-34be4c003561
U.S. Food and Drug Administration. (n.d.). FDA-approved drug products. Retrieved 1 April 2024, from https://www.fda.gov/media/71427/download
Stoner, S. (2008). Extended-release divalproex in bipolar and other psychiatric disorders: A comprehensive review. Neuropsychiatric Disease and Treatment, Volume 3, 839–846. https://doi.org/10.2147/ndt.s1264
Zhang, C. Q., Li, H. Y., Wan, Y., Bai, X. Y., Gan, L., Wang, J., & Sun, H. B. (2022). Efficacy, safety, and Retention Rate of Extended-Release Divalproex versus Conventional Delayed-Release Divalproex: A Meta-Analysis of Controlled Clinical Trials. Frontiers in Pharmacology, 13. https://doi.org/10.3389/fphar.2022.811017

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