Colochicine 05 Mg Tablet 10

Colochicine 0.5 MG Tablet 10

Zydus Cadila

Pack of 10 Units

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MRP ~~₹10.58~~

₹8.68

₹1.06/Units

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Composition

Colchicine (0.5 Mg)

Colchicine-0.5 MG Tablet is utilised to manage gout attacks and prevent future episodes. It belongs to the class of anti-gout agents, designed to alleviate the discomfort associated with this form of arthritis.

This medicine is also beneficial in managing Familial Mediterranean Fever (FMF). This inherited condition, affecting adults and children aged 4 years and above, presents recurrent episodes of fever, abdominal pain, lung inflammation, and joint pain.

Always remember, it's crucial to take this medicine as directed by your doctor. Before starting on this medicine, inform your doctor of any pre-existing conditions or current medicines you may be on. Should you notice any side effects while taking this medicine, notify your doctor promptly. For the best results, continue taking the medicine for the duration prescribed by your doctor.

Colchicine-0.5 MG Tablet is used for the following:

Managing acute gout attacks
Preventing future gout flares
Controlling familial Mediterranean fever in adults and children aged 4 years and older

Directions for Use of Colochicine 0.5 MG Tablet 10

Swallow the tablet whole with a glass of water.
Don't crush or chew the tablet.
Stick to the dose recommended by your doctor.
If you're unsure about anything, always consult your doctor.

Colchicine-0.5 MG Tablet is taken orally.

Side Effects of Colochicine 0.5 MG Tablet 10

Colchicine-0.5 MG Tablet may have the following common side effects:

Diarrhoea
Nausea
Vomiting
Abdominal pain or cramps
Muscle pain or weakness
Numbness or tingling in fingers or toes
Unusual bleeding or bruising
Sore throat, fever, or chills
Pale or greyish skin, lips, or tongue

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing the use of Colchicine-0.5 MG Tablet. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are some general guidelines for managing common side effects:

Diarrhoea: Consume plenty of water and healthy fluids to avoid dehydration.
Nausea: Consider taking this medicine at night if it makes you feel sick during the day.

Colchicine-0.5 MG Tablet contains colchicine (0.5 mg) which works in the body as follows:

Inhibits Leukocyte Migration and Activity: Colchicine works by suppressing the movement and function of white blood cells, or leukocytes, in affected areas. This reduction in activity helps to decrease inflammation.
Prevents Uric Acid Crystal Deposition: The principal cause of gout attacks is the buildup of uric acid crystals in the joints. Colchicine interferes with this process, preventing the accumulation of these crystals, thus aiding in the management of gout symptoms.

Pregnancy

Caution is advised while taking Colchicine-0.5 MG Tablet if you are pregnant. It is best to consult your doctor before taking this medicine.

Breastfeeding

If you are breastfeeding, use of Colchicine-0.5 MG Tablet requires caution. Discuss the potential risks and benefits with your doctor.

Alcohol

It is not recommended to consume alcohol while on Colchicine-0.5 MG Tablet as it may exacerbate side effects or alter the medicine's effectiveness. Consult your doctor for more information.

Liver

If you have liver problems, discuss them with your doctor before starting Colchicine-0.5 MG Tablet. This medicine may affect liver function.

Kidney

Caution is advised before using Colchicine-0.5 MG Tablet if you have a history of any kidney problems. It is a good idea to consult your doctor before taking this medicine.

Using Machines & Driving

There is no specific information about whether Colchicine-0.5 MG Tablet affects driving or operating machinery. If you experience any side effects that may impair these activities, consult your doctor.

Allergy

If you have allergies to colchicine or any other medications, inform your doctor before starting Colchicine-0.5 MG Tablet to avoid adverse reactions.

Children

Colchicine-0.5 MG Tablet can be given to children aged 4 years and above for managing familial Mediterranean Fever (FMF). However, always consult your doctor before giving this medicine to a child.

Older Patients

Older patients should take Colchicine-0.5 MG Tablet under medical supervision as they may be more susceptible to its side effects. Caution is advised if patients are above 70 years of age since they might also have liver and kidney issues and might be on other medication. Your doctor will guide you based on your health status.

Interactions of Colochicine 0.5 MG Tablet 10

Drug-Drug Interactions

Colchicine-0.5 MG Tablet interacts with the following medicines:

Antibiotics: Medications like clarithromycin and erythromycin may interact with Colchicine-0.5 MG Tablet, potentially increasing the risk of side effects due to increased levels of colchicine in your body.
Antifungals: If taken with Colchicine-0.5 MG Tablet, antifungal medicines like itraconazole and ketoconazole can increase the concentration of colchicine in your blood, leading to an increased risk of toxicity.
HIV Medications: HIV medicines such as atazanavir, indinavir, and ritonavir can increase the absorption of colchicine, thereby increasing its effects and side effects.
Heart Medications: Medicines like diltiazem and verapamil may interact with Colchicine-0.5 MG Tablet, increasing its levels in your body and potentially leading to increased side effects.
Cholesterol-Lowering Medicines: When taken alongside Colchicine-0.5 MG Tablet, cholesterol-lowering medicines like atorvastatin and simvastatin can increase the risk of muscle injury.

Drug-Food Interactions

Colchicine-0.5 MG Tablet has no known significant interactions with food items.

Drug-Disease Interactions

Colchicine-0.5 MG Tablet interacts with the following diseases:

Kidney Disease: Patients with kidney disease should be cautious as higher levels of colchicine can accumulate in their bodies leading to increased risk of side effects.
Liver Disease: If you have liver disease, Colchicine-0.5 MG Tablet could exacerbate your condition by causing an increased concentration of colchicine in the body.
Blood Disorders: People with blood disorders should exercise caution as Colchicine-0.5 MG Tablet could potentially worsen their condition.

Daily Dose

The daily dose of Colchicine-0.5 MG Tablet is prescribed by your doctor, based on individual factors such as the severity of your condition and your response to the medicine. Always follow the prescribed dosage and never exceed it without consulting your doctor. For further details regarding dosage, refer to the package insert.

Over Dose

If you accidentally take more than the prescribed dose of Colchicine-0.5 MG Tablet, you may experience symptoms such as severe nausea, vomiting, diarrhoea and abdominal pain. If these symptoms persist, inform your doctor.

Missed Dose

If you forget to take your dose of Colchicine-0.5 MG Tablet, take it as soon as you remember. However, if it's nearly time for your next dose, skip the missed one and continue with your regular dosage schedule. Never adjust your dosage without consulting your doctor.

Store Colchicine-0.5 MG Tablet at room temperature, ideally below 30°C.
Keep the medicine away from excessive light and moisture.
Always ensure that the medicine is out of reach of children.
Check the expiry date on the pack and avoid using the product after this date.

For those managing gout with Colchicine-0.5 MG Tablet, aim to limit your intake of purine-rich foods such as red meat, seafood, and alcohol, as these can contribute to uric acid buildup.
If using this medicine for Familial Mediterranean Fever (FMF), regular physical activity may help reduce inflammation and joint pain; however, always consult your doctor before starting any new exercise regimen.

Fact Box

Drug Category	Anti-gout Agent
Therapeutic Category	Anti-inflammatory
Available Dosage Types	Tablet
Habit Forming	No
Ailment	Gout, Familial Mediterranean Fever

What does Colchicine-0.5 MG Tablet manage?

Colchicine-0.5 MG Tablet is used to manage gout attacks and familial Mediterranean fever (FMF), an inherited condition with recurrent fevers and pains.

How does Colchicine-0.5 MG Tablet work?

It works by decreasing the activity of white blood cells in affected areas, reducing inflammation and preventing uric acid crystal buildup in joints.

What are the common side effects of Colchicine-0.5 MG Tablet?

Common side effects include diarrhoea, nausea, vomiting, and abdominal cramps. Consult your doctor if these persist or worsen.

Are there any serious side effects associated with Colchicine-0.5 MG Tablet?

Yes, serious side effects may include muscle pain, unusual bleeding, signs of infection like sore throat or fever, and pale skin. Consult your doctor immediately if you notice these.

What precautions should I take before using Colchicine-0.5 MG Tablet?

Inform your doctor if you have kidney or liver disease, blood disorders or allergies to colchicine or other medications before taking this medicine.

Can Colchicine-0.5 MG Tablet interact with other medicines?

Yes, it can interact with certain antibiotics, antifungals, HIV medications, heart medications and cholesterol-lowering medications. Always inform your doctor about all the medicines you're taking.

What should I do in case of a suspected overdose of Colchicine-0.5 MG Tablet?

In case of a suspected overdose with symptoms like severe nausea or muscle weakness, contact your local poison control centre or emergency medical services immediately.

Certified Content

Written by

Dr Nikita Lobo

Medical Editor & Reviewer | 7 years

BDS, MDS

Reviewed by

Dr. Chhavi Rosha

Health & Medical Content Writer | 8 years

BMS, FMC, MD Resident

Check out Editorial Policy

Manufacturer details

5V74+4P2, Jay Prakash Nagar, Goregaon, Mumbai, Maharashtra 400063

References

Takeda Pharmaceuticals America, Inc. (2012). HIGHLIGHTS OF PRESCRIBING INFORMATION. https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/022352s017lbl.pdf
AGEPHA Pharma FZ LLC. (2023). LODOCO (colchicine) tablets, for oral use [Prescribing information]. https://www.accessdata.fda.gov/drugsatfda_docs/label/2023/215727s000lbl.pdf
Mutual Pharmaceutical Company, Inc. (2009). HIGHLIGHTS OF PRESCRIBING INFORMATION [Prescribing information]. https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/022351lbl.pdf
Romeg Therapeutics, LLC. (2019). Highlights of prescribing information. https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/210942s000lbl.pdf
Sadiq, N. M., Robinson, K. J., & Terrell, J. M. (2023, May 29). Colchicine. StatPearls - NCBI Bookshelf. https://www.ncbi.nlm.nih.gov/books/NBK431102/
Colchicine: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB01394

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