Clofaz 100 Mg Soft Gelatin Capsule 10

Clofaz 100 MG Soft Gelatin Capsule 10

Genetiac Pharma

Pack of 10 Units

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MRP ~~₹26.25~~

₹21.52

₹2.63/Units

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Composition

Clofazimine (100 Mg)

Clofaz 100 Capsule is primarily employed to manage leprosy, an infectious disease which leads to skin lesions and nerve damage. This medication falls under a group of medicines known as antibiotics.

In addition to its principal role in managing leprosy, the medicine is used as part of a multi-medicine therapy regimen recommended by the World Health Organisation. This treatment approach boosts the effectiveness of the medicine and curtails the potential emergence of medicine resistance.

Before you start taking this medicine, it's crucial to consult your doctor regarding the right dosage and frequency. It's equally important to inform your doctor about any ongoing medications or pre-existing health conditions. If you notice any side effects while on this medication, notify your doctor immediately. Lastly, ensure you follow the prescribed course, even if symptoms improve, to prevent any possibility of relapse.

Uses of Clofaz 100 MG Soft Gelatin Capsule 10

Clofaz 100 Capsule is used for the following:

Management of leprosy also known as Hansen's disease
Prevention of medicine resistance in leprosy treatment
Part of a multi-medicine therapy regimen for chronic bacterial infection

Directions for Use of Clofaz 100 MG Soft Gelatin Capsule 10

Here are some instructions to follow when you take Clofaz 100 Capsule:

Swallow the capsule whole with water.
Do not crush or chew the capsule.
It is recommended to take this medicine with food.
Do not stop taking this medicine without consulting your doctor, even if your symptoms improve.

Clofaz 100 Capsule is taken orally.

Side Effects of Clofaz 100 MG Soft Gelatin Capsule 10

While taking Clofaz 100 Capsule, you may experience:

Skin discolouration: This refers to a change in your skin colour, which could turn reddish to brownish-black.
Stomach pain
Nausea
Vomiting
Diarrhoea
Dry eyes
Dimmed vision: This means your sight might not be as clear as usual.
Eye irritation
Dryness and discolouration of bodily fluids: Your sweat, tears, sputum, and urine might change in colour and dryness.

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve upon discontinuing the use of Clofaz 100 Capsule. However, if you experience any serious side effects or worsening of any symptoms, please consult your doctor.

Here are some tips to manage a couple of the common side effects:

Stomach pain: Try taking Clofaz 100 Capsule with food or milk to lessen this effect.
Diarrhoea: Consider taking this medicine after meals to mitigate this side effect.

How Clofaz 100 MG Soft Gelatin Capsule 10 Works?

Clofaz 100 Capsule contains clofazimine (100 mg) which works on the body in the following ways:

DNA Binding: Clofazimine binds to the DNA of Mycobacterium leprae, the bacteria responsible for leprosy. This binding disrupts the bacterial DNA, essentially interfering with its functioning.
Inhibition of Bacterial Growth: By disrupting the DNA, clofazimine effectively inhibits the growth and multiplication of the bacteria.
Control and Elimination of Infection: By stopping the bacteria from reproducing, clofazimine helps manage the infection over time, eventually eliminating it from the body.

Pregnancy

Clofaz 100 Capsule should be used during pregnancy only if clearly needed. Consult your doctor to understand potential risks and benefits before starting this medication.

Breastfeeding

Caution is advised while taking Clofaz 100 Capsule if you are breastfeeding. It may pass into breast milk and cause side effects in a nursing baby. Discuss with your doctor before using this medicine.

Alcohol

It's best to avoid alcohol while taking Clofaz 100 Capsule, as it may increase the risk of side effects. Consult your doctor for more details.

Liver

If you have liver health issues, it is advised to consult your doctor before starting Clofaz 100 Capsule. Your doctor will guide you based on the health status of your liver.

Kidney

Caution is advised before using Clofaz 100 Capsule if you have a history of kidney problems. It is a good idea to consult your doctor before taking this medicine.

Using Machines & Driving

There's no direct impact of Clofaz 100 Capsule on your ability to operate heavy machinery or drive. However, if you experience any side effects that can affect these activities, such as blurred vision, avoid driving or operating machinery until you feel better.

Allergy

Clofaz 100 Capsule is contraindicated in patients with known hypersensitivity to clofazimine or any other ingredients in the medicine. If you have any allergies, discuss them with your doctor before starting this medicine.

Children

Clofaz 100 Capsule is meant for adults. It should not be given to children unless a doctor recommends it after weighing the benefits against potential risks.

Older Patients

Older patients should take Clofaz 100 Capsule under medical supervision as they may be more susceptible to its side effects. Caution is advised if patients are above 70 years of age. Your doctor will guide you based on your health status.

Interactions of Clofaz 100 MG Soft Gelatin Capsule 10

Drug-Drug Interactions

Clofaz 100 Capsule interacts with the following medicines:

Antibiotics: Medicines such as bedaquiline and delamanid may interact with Clofaz 100 Capsule, increasing the risk of heart rhythm problems.
Anticoagulants: When taken with warfarin, Clofaz 100 Capsule can increase the risk of bleeding.
Oral contraceptives: Clofaz 100 Capsule may reduce the effectiveness of oral contraceptives like estradiol.
Antacids: These medications like omeprazole and aluminum hydroxide can decrease clofazimine absorption when taken with Clofaz 100 Capsule.

Drug-Food Interactions

Drug-Disease Interactions

Clofaz 100 Capsule interacts with the following diseases:

Liver Disease: People having liver disease should exercise caution as Clofaz 100 Capsule could exacerbate their condition.
Kidney Disease: Caution is required for people with kidney disease while using this medicine as it may worsen their condition.
Gastrointestinal Disorders: This medicine may worsen existing gastrointestinal issues.

Dosage of Clofaz 100 MG Soft Gelatin Capsule 10

Daily Dose

The daily dose of Clofaz 100 Capsule is taken as prescribed by your doctor. The dosage may vary depending on individual factors such as the severity of the condition and response to the medicine. It is crucial to adhere to the prescribed dosage and avoid exceeding it without consulting your doctor.

Over Dose

In case of an accidental overdose, you might experience more pronounced common side effects. If you notice these symptoms persisting or worsening, kindly inform your doctor for appropriate advice.

Missed Dose

If you forgot to take Clofaz 100 Capsule at the scheduled time, take it as soon as you remember. However, if it's nearly time for your next dose, skip the missed one and continue with your regular dosage schedule. Never increase your dosage without consulting your doctor.

Keep Clofaz 100 Capsule in a tightly sealed container at room temperature.
Protect the medicine from excessive light and moisture.
Safely store it out of the reach and sight of children.
Always ensure to use your medicine before the expiry date printed on the pack.

Regularly include vitamin-rich foods in your diet. Vitamins are essential for skin health and may help manage skin conditions associated with leprosy.
Practice good hygiene, like washing hands regularly and keeping wounds clean, to prevent potential bacterial infections that may complicate leprosy management.

Fact Box

Drug Category	Riminophenazines
Therapeutic Category	Antibiotic
Available Dosage Types	Capsule
Habit Forming	No
Ailment	Leprosy (Hansen's disease)

What is Clofaz 100 Capsule used for?

Clofaz 100 Capsule is used to manage leprosy, an infectious disease that can cause skin lesions and nerve damage.

How does Clofaz 100 Capsule work?

It contains clofazimine, which inhibits the growth of bacteria causing leprosy by disrupting their DNA, thus controlling the infection.

Can I take Clofaz 100 Capsule with food?

Yes, taking Clofaz 100 Capsule with meals is advised as it can improve absorption and reduce gastrointestinal issues.

What should I do If I miss a dose?

If you miss a dose of Clofaz 100 Capsule, take it as soon as you remember unless it's near the time for your next dose.

Will my skin colour return to normal after stopping the medicine?

Yes, the skin discoloration caused by Clofaz 100 Capsule is reversible but may take months to years to fade completely after discontinuation.

Is Clofaz 100 Capsule safe for long-term use?

When used as directed by a doctor for managing leprosy, Clofaz 100 Capsule is considered safe for long-term use. Regular check-ups are crucial to monitor any adverse effects.

Can other medicines interact with Clofaz 100 Capsule?

Yes, certain medicines can interact with Clofaz 100 Capsule. It's important to inform your doctor about all medications you're using before starting this medicine.

Certified Content

Written by

Dr Nikita Lobo

Medical Editor & Reviewer | 7 years

BDS, MDS

Reviewed by

Dr. Chhavi Rosha

Health & Medical Content Writer | 8 years

BMS, FMC, MD Resident

Check out Editorial Policy

Manufacturer details

1098, G J Patel Estate, Bajwa, Vadodara - 391310, Near Government Hospital

References

SUMMARY OF PRODUCT CHARACTERISTICS. (n.d.). Retrieved November 13, 2024, from http://www.efda.gov.et/wp-content/uploads/2023/11/Clofazimine-Tablet-50mg_Macleods-Pharmaceuticals-Ltd.pdf
Clofazimine (Lamprene) Package Insert | DAIDS Regulatory Support Center (RSC). (2020). Nih.gov. https://rsc.niaid.nih.gov/clinical-research-sites/clofazimine-lamprene
Riccardi, N., Giacomelli, A., Canetti, D., Comelli, A., Intini, E., Gaiera, G., Diaw, M. M., Udwadia, Z., Besozzi, G., Codecasa, L., & Biagio, A. D. (2020). Clofazimine: an old drug for never-ending diseases. Future Microbiology, 15(7), 557–566. https://doi.org/10.2217/fmb-2019-0231
Clofazimine. (2017, October 13). Nih.gov; National Institute of Diabetes and Digestive and Kidney Diseases. https://www.ncbi.nlm.nih.gov/books/NBK548658/

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