Azorase Tablet 10

Heramb Healthcare

Pack of 10 Units

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MRP ~~₹91~~

₹74.62

₹9.10/Units

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Composition

Azathioprine (50 Mg)

Strength:

50 MG 25 MG

Azorase Tablet 10 is primarily used to prevent the body from rejecting a transplanted kidney. This medicine belongs to a category of medications known as immunosuppressants.

Beyond this principal role, this tablet also helps manage the symptoms of severe rheumatoid arthritis. It's particularly effective for those who have not responded adequately to initial treatments such as non-steroidal anti-inflammatory drugs (NSAIDs) and disease-modifying antirheumatic drugs (DMARDs).

This medicine should be taken orally, strictly as directed by your doctor. Before starting on this medication, you must inform your doctor about any pre-existing conditions or ongoing medications you might be taking. Should you notice any side effects while using this medicine, notify your doctor immediately. For the best results, continue taking the medicine for the duration your doctor prescribes.

Azorase Tablet 10 is used for the following:

Helps prevent the body's immune system from attacking and rejecting the newly transplanted kidney
Manage severe rheumatoid arthritis symptoms when first-line treatments fail to provide adequate relief

Here's how you should take Azorase Tablet 10:

Swallow the tablet whole with a glass of water. Chewing or crushing the tablet is not advisable.
Taking this medicine with food is best, as it can help minimise possible stomach discomfort.
Do not exceed the dose recommended by your doctor.
Always consult your doctor before changing how you take this medicine.

Azorase Tablet 10 is taken orally.

Azorase Tablet 10 may have the following common side effects:

Nausea
Vomiting
Diarrhoea
Fatigue
Decrease in the production of blood cells
Medicine-induced liver damage

Managing the Side Effects:

Most side effects are temporary and generally harmless and resolve upon discontinuing use of Azorase Tablet 10. However, if you experience serious side effects or worsening symptoms, please consult your doctor.

Here are some general guidelines for managing common side effects:

Nausea: Try taking Azorase Tablet 10 with food to lessen this effect.
Diarrhoea: Ensure you stay hydrated by drinking plenty of fluids.

Azorase Tablet 10 contains azathioprine (50 mg), which operates on your body in a specific manner:

Inhibition of Purine Synthesis: Azathioprine works by hampering purine synthesis in the body. Purines are necessary for DNA and RNA production. By inhibiting their synthesis, azathioprine suppresses immune responses mediated by T cells.
Disruption of DNA Synthesis: After being absorbed by the body, azathioprine is converted into 6-mercaptopurine, which then transforms into 6-thioguanine nucleotides. These nucleotides disrupt DNA synthesis and inhibit the growth of fast-dividing cells like T and B lymphocytes, resulting in the suppression of the immune system.

Pregnancy

Azorase Tablet 10 is contraindicated during pregnancy. If you are pregnant or planning to conceive, ensure to discuss this with your doctor before starting this medicine.

Breastfeeding

Azorase Tablet 10 is not recommended for breastfeeding women. It's imperative to consult your doctor to understand the potential risks and benefits.

Alcohol

To stay safe, you should minimise or avoid alcohol consumption when on this medicine.

Liver

If you have mild to severe liver issues, caution is advised while taking Azorase Tablet 10. This medicine might affect liver function. Discuss your liver health with your doctor before starting this medication.

Kidney

Caution is advised while taking Azorase Tablet 10 if you have a history of any kidney problems. It's best to consult your doctor before starting this medicine.

Using Machines & Driving

Azorase Tablet 10 is not known to affect your ability to drive or operate machinery. However, if you experience any side effects that may impact your skills, refrain from these activities and speak to your doctor.

Allergy

If you are known to be allergic to azathioprine or any other component of Azorase Tablet 10, avoid taking this medicine. Always inform your doctor about your allergy history.

Children

Azorase Tablet 10 is meant for adult use. Therefore, caution is advised while giving this medicine to children under 18. Always consult your doctor before giving any medicine to a child.

Older Patients

Older patients should take Azorase Tablet 10 under medical supervision as they may be more susceptible to its side effects. Caution is advised if patients are over 70 years of age. Your doctor will guide you based on your health status.

Drug-Drug Interactions

Azorase Tablet 10 interacts with the following medicines:

Immunosuppressants: Combining azathioprine with other immunosuppressants like cyclosporine can increase the risk of severe immunosuppression and infections.
ACE Inhibitors: Medications such as lisinopril can increase the risk of blood dyscrasias, including leukopenia.
Aminosalicylates: Medicines like mesalamine and sulfasalazine can increase the bone marrow suppression effects of azathioprine.

Drug-Food Interactions

There are no known specific food interactions with Azorase Tablet 10.

Drug-Disease Interactions

Azorase Tablet 10 interacts with the following diseases:

Liver Disease: If you have liver disease, Azorase Tablet 10 might worsen your condition, so you must be extra careful.
Infections: If you have an infection, taking Azorase Tablet 10 could make it harder for your body to fight it off because this medicine weakens your immune system.

Daily Dose

Your doctor determines the daily dose of Azorase Tablet 10, considering factors like the severity of your condition and how you respond to the medication. Stick to the prescribed regimen and don't exceed it without consulting your doctor.

Over Dose

If you mistakenly take more Azorase Tablet 10 than prescribed, you might feel nauseous or experience vomiting and diarrhoea. However, do not panic and inform your doctor about it.

Missed Dose

If you miss a dose of Azorase Tablet 10, take it as soon as you remember. But if it's nearly time for your next dose, skip the missed one and continue with your regular schedule. Never adjust the dosage without discussing it with your doctor.

Store Azorase Tablet 10 away from direct sunlight and moist environments.
Keep the packaging tightly closed when not in use to protect it from air and light exposure.
Always place the medicine out of the reach of children and pets.
Ensure you use this medicine before its expiry date.

If you're managing rheumatoid arthritis with Azorase Tablet 10, incorporate gentle exercise routines into your daily schedule. This can help maintain joint flexibility and reduce stiffness.
Maintaining a balanced diet low in sodium and fibre is recommended for patients who have undergone kidney transplantation. This supports kidney health and helps manage overall well-being. Always consult your doctor for individual dietary advice.

Fact Box

Drug Category	Immunosuppressant Antimetabolite
Therapeutic Category	Immunosuppressive Medication
Available Dosage Types	Tablet
Habit Forming	No
Ailment	Kidney Transplant Rejection, Rheumatoid Arthritis

What is Azorase Tablet 10 used for?

It's used to prevent the body from rejecting a kidney after a transplant and to manage severe rheumatoid arthritis symptoms.

How does Azorase Tablet 10 work in the body?

It contains azathioprine, which suppresses the immune system by disrupting DNA synthesis in rapidly dividing cells like T and B lymphocytes.

Are there any contraindications to using Azorase Tablet 10?

Yes, it should not be taken if you're allergic to azathioprine or if you're a pregnant woman with rheumatoid arthritis. Always consult your doctor for personalised guidance.

Can Azorase Tablet 10 interact with other medications?

Yes, it can interact with several medicines, such as allopurinol and warfarin, potentially leading to adverse effects. Always inform your doctor about all the medicines you're taking.

What are some precautions I should take while using Azorase Tablet 10?

Regular blood tests are crucial to monitor for side effects such as liver damage, infections, and blood disorders. Report any unusual symptoms promptly.

Are there any side effects associated with Azorase Tablet 10?

Common side effects include nausea and fatigue. Serious ones include liver damage, infections, and blood disorders, among others. Promptly report any unusual symptoms to your doctor.

How should I store my Azorase Tablet 10?

Store it in its original package, away from light and moisture, and out of the reach of children and pets.

Certified Content

Written by

Dr Nikita Lobo

Medical Editor & Reviewer | 7 years

BDS, MDS

Reviewed by

Dr. Chhavi Rosha

Health & Medical Content Writer | 8 years

BMS, FMC, MD Resident

Check out Editorial Policy

Manufacturer details

F. NO. 01, ISHANYA BLOSSOM APTS, S. NO 65/3/3/2, P. NO 23, ANANDWALI SHIWAR, GANGAPUR ROAD NASHIK Nashik MH 422013 IN

Country of origin: INDIA

References

FDA. (2002). IMURAN (azathioprine) 50-mg Scored Tablets. https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/016324s034s035lbl.pdf
NEW ZEALAND DATA SHEET. (n.d.). IMURAN 25mg, 50mg tablets. In NEW ZEALAND DATA SHEET. https://www.medsafe.govt.nz/profs/datasheet/i/Imurantab.pdf
Mohammadi, O., & Kassim, T. A. (2023, May 1). Azathioprine. StatPearls - NCBI Bookshelf. https://www.ncbi.nlm.nih.gov/books/NBK542190/
Azathioprine: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB00993
Azathioprine: MedlinePlus Drug Information. (n.d.). https://medlineplus.gov/druginfo/meds/a682167.html

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