Alrista 150 Mg Tablet Sr 10

Alrista Sr Tablet 10

Macleods Pharmaceuticals Pvt.ltd

Strip of 10 Units

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MRP ~~₹169.4~~

₹138.91

₹16.94/Units

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Composition

Epalrestat (150 Mg)

Alrista SR Tablet is primarily used for managing diabetic neuropathy, a nerve-related complication of diabetes. It falls under a class of medicines known as aldose reductase inhibitors which are known to be effective in managing complications arising from diabetes.

This tablet helps improve nerve function and reduce neuropathic pain in diabetic patients. Chronic high blood sugar levels can lead to damage in the nerves over time, and this tablet helps prevent this nerve damage.

It is crucial that this medicine is taken as directed by your doctor. Make sure to inform your doctor about pre-existing conditions or ongoing medications before starting this medicine. If you observe any side effects while on this medication, notify your doctor immediately. For optimal results, continue taking the medicine for the duration prescribed by your doctor.

Here are the conditions that Alrista SR Tablet helps manage:

Management of diabetic neuropathy, a condition where high blood sugar levels damage your nerves over time.
Aids in enhancing the functioning of nerves affected by diabetes.
Reduction of neuropathic pain caused by nerve damage in individuals with diabetes.

Directions for Use of Alrista Sr Tablet 10

Swallow the tablet whole with a glass of water. Do not crush or chew it.
You can take it with or without food, as directed by your doctor.
Try to take your medicine at the same time each day for consistent effectiveness.
Do not stop taking this medication without consulting your doctor first.

Alrista SR Tablet is taken orally.

Alrista SR Tablet may have the following common side effects:

Nausea
Diarrhoea
Abdominal pain
Flatulence
Dizziness
Headache
Rash
Itching

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve upon discontinuing the use of Alrista SR Tablet. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are some suggestions to manage a couple of common side effects:

Nausea: Try taking Alrista SR Tablet with food or milk.
Diarrhoea: Consider taking this medicine at night if it causes you diarrhoea during the day.

Alrista SR Tablet has a single active ingredient, Epalrestat (150 mg), which works on your body through two main mechanisms:

Aldose Reductase Inhibition: Epalrestat blocks an enzyme called aldose reductase in your body. This enzyme converts glucose into sorbitol when blood sugar levels are high.
Reduction of Sorbitol Accumulation: By blocking aldose reductase, Epalrestat significantly reduces the accumulation of sorbitol inside your nerve cells. This prevents structural damage and oxidative stress on the nerves caused by excessive sorbitol and improves nerve function in patients with diabetic neuropathy.

Pregnancy

Caution is advised while taking Alrista SR Tablet if you are pregnant. It is best to consult your doctor before taking this medicine.

Breastfeeding

Safety during breastfeeding has not been established for Alrista SR Tablet. Always consult your doctor if you are nursing.

Alcohol

Alrista SR Tablet can interact with alcohol, increasing the likelihood of side effects like dizziness and drowsiness. Limit your alcohol consumption while on this medication.

Liver

Use Alrista SR Tablet with caution if you have pre-existing liver conditions as it is metabolised by the liver. Regular monitoring of liver functions is advisable.

Kidney

The safety of Alrista SR Tablet in patients with kidney issues has not been established. It's advised to consult your doctor before initiating this medicine if you have a history of kidney problems.

Using Machines & Driving

Dizziness and drowsiness, which can be side effects of Alrista SR Tablet, may affect your ability to drive or operate machinery. Be cautious until you know how the medicine affects you.

Allergy

Avoid using Alrista SR Tablet if you are allergic to epalrestat or any other ingredients in the tablet. If you experience allergic symptoms such as skin rashes or difficulty breathing, contact your doctor immediately.

Children

Alrista SR Tablet is not recommended for use in children. Consult with your doctor for alternatives if needed.

Older Patients

Elderly patients should take Alrista SR Tablet under medical supervision as they may be more susceptible to its side effects, particularly those related to liver and kidney health. Your doctor will guide you based on your health status.

Drug-Drug Interactions

Alrista SR Tablet interacts with the following medicines:

Antidiabetic Medications (e.g., Metformin, Glimepiride): Epalrestat may enhance the effects of these medications, increasing the risk of hypoglycemia.
ACE Inhibitors (e.g., Lisinopril, Enalapril): When used together, there could be a risk of an additive effect on blood pressure, potentially leading to low blood pressure.
NSAIDs (e.g., Ibuprofen, Naproxen): Co-administration with NSAIDs may increase the risk of kidney function impairment, especially in patients with existing renal issues.
Diuretics: Epalrestat may alter the efficacy of furosemide and hydrochlorothiazide, potentially affecting their role in managing blood pressure or fluid retention.

Drug-Food Interactions

No specific food interactions have been reported with Alrista SR Tablet.

Drug-Disease Interactions

Alrista SR Tablet interacts with the following diseases:

Liver disease: Alrista SR Tablet should be used with caution in patients with pre-existing liver disease as epalrestat is metabolised in the liver. The medication might, therefore, affect how your liver functions.

Daily Dose

The daily dose of Alrista SR Tablet is taken as directed by your doctor. The dosage may vary based on individual factors. Always adhere to your doctor's prescribed dosage.

Over Dose

An overdose of Alrista SR Tablet might lead to enhanced side effects like diarrhoea, headache, or dizziness. If you suspect an overdose, it's recommended to consult your doctor.

Missed Dose

If you forget to take Alrista SR Tablet, take it as soon as you remember. However, skip the missed dose if it's nearly time for the next one.

Store Alrista SR Tablet at room temperature.
Keep the medicine away from direct sunlight, heat, and moisture.
Always keep it in its original packaging until you're ready to take it.
Ensure you place it out of reach of children.
Make sure to use this medicine before its expiry date.

Aim to maintain a balanced diet that's low in sugar. This can help manage your blood sugar levels efficiently, which is crucial when dealing with diabetic neuropathy.
Regularly exercise to improve circulation and reduce symptoms associated with diabetic neuropathy. However, remember to wear comfortable, well-fitted shoes during physical activities to prevent any foot injury. Always consult your doctor before starting any new exercise regimen.

Fact Box

Drug Category	Aldose Reductase Inhibitor
Therapeutic Category	Antidiabetic
Available Dosage Types	Tablet Sr
Habit Forming	No
Ailment	Diabetic Neuropathy, Nerve Pain

What is Alrista SR Tablet used for?

Alrista SR Tablet is used to manage diabetic neuropathy, a condition where high blood sugar levels damage nerves over time.

How does Alrista SR Tablet work?

The active ingredient in Alrista SR Tablet, epalrestat, inhibits an enzyme called aldose reductase, reducing the build-up of harmful substances in nerve cells.

Can I take Alrista SR Tablet with food?

Yes, Alrista SR Tablet can be taken with or without food. Consult your doctor for personalised advice.

What are the common side effects of Alrista SR Tablet?

Common side effects include gastrointestinal disturbances such as nausea and diarrhoea, dizziness, headache, rash or itching.

Are there any precautions I should take when using Alrista SR Tablet?

Use with caution if you have liver impairment, and always inform your doctor about other medications you're taking to avoid interactions.

Can I consume alcohol while using Alrista SR Tablet?

Limit your alcohol intake while on this medication, as it may increase drowsiness and dizziness.

How should I store my Alrista SR Tablets?

Store at room temperature in a dry place away from direct sunlight and moisture. Keep out of reach of children.

Certified Content

Written by

Dr Nikita Lobo

Medical Editor & Reviewer | 7 years

BDS, MDS

Reviewed by

Dr. Chhavi Rosha

Health & Medical Content Writer | 8 years

BMS, FMC, MD Resident

Check out Editorial Policy

Manufacturer details

Atlanta Arcade, Marol Church Rd, Bori Colony, Vijay Nagar Colony West, Marol, Andheri East, Mumbai, Maharashtra 400059

Country of origin: INDIA

References

Epalrestat: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB15293
Sharma, S., & Sharma, N. (2008). RETRACTED: Epalrestat, an aldose reductase inhibitor, in diabetic neuropathy: An Indian perspective. Annals of Indian Academy of Neurology, 11(4), 231. https://doi.org/10.4103/0972-2327.44558
Ramirez, M. A., & Borja, N. L. (2008). Epalrestat: an aldose reductase inhibitor for the treatment of diabetic neuropathy. Pharmacotherapy the Journal of Human Pharmacology and Drug Therapy, 28(5), 646–655. https://doi.org/10.1592/phco.28.5.646
Shi, W., Xu, G., Gao, Y., Zhao, J., Liu, T., Zhao, J., Yang, H., Wei, Z., Li, H., Xu, A., Bai, Z., & Xiao, X. (2023). Novel role for epalrestat: protecting against NLRP3 inflammasome-driven NASH by targeting aldose reductase. Journal of Translational Medicine, 21(1). https://doi.org/10.1186/s12967-023-04380-4

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