Actizo 20120 Mg Tablet 8

Actizo 20/120 MG Tablet 8

Ranbaxy Laboratories Ltd

Strip of 8 Units

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MRP ~~₹90.47~~

₹74.19

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Composition

Artemether (20 Mg) + Lumefantrine (120 Mg)

Actizo 20/120 MG Tablet 8 is primarily used to manage cases of uncomplicated malaria caused by Plasmodium falciparum. It is a combination medication in the category of antimalarial medicines. This medicine is typically prescribed when other antimalarial medicines prove ineffective.

Besides its principal use, this tablet is also employed in areas where the malaria-causing parasites have developed resistance to other antimalarial medicines. The medicine, being a combination of two active ingredients, works synergistically to inhibit the growth and reproduction of these malarial parasites.

It's crucial to take this medicine as directed by your doctor and consistently follow the prescribed regimen for optimal results. Before starting this medicine, be sure to inform your doctor about any existing health conditions or ongoing medications. If you experience any side effects while taking this medicine, notify your doctor immediately. Remember to continue the medication for the full duration prescribed by your doctor.

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Actizo 20/120 MG Tablet 8 is used for the following:

Managing uncomplicated malaria caused by Plasmodium falciparum, a type of malaria transmitted through infected mosquitoes.
Providing an alternative for patients resistant to other antimalarial medicines.

Directions for Use of Actizo 20/120 MG Tablet 8

Here's how you should take Actizo 20/120 MG Tablet 8:

Swallow the tablet whole with a glass of water.
If needed, you can crush the tablet and mix it with water to make it easier to swallow.
Always take this medicine along with food or drinks like milk, infant formula, pudding, porridge, or broth. This helps the medication be better absorbed and reduces the risk of stomach upset.
Never exceed the recommended dose unless advised differently by your doctor.

Actizo 20/120 MG Tablet 8 is taken orally.

Side Effects of Actizo 20/120 MG Tablet 8

Actizo 20/120 MG Tablet 8 may cause the following common side effects:

Headache
Dizziness
Fatigue
Nausea and vomiting
Abdominal pain
Cough
Anorexia: This is a loss of appetite, which could lead to weight loss.
Muscle and joint pain
Palpitations: This refers to an irregular or rapid beating of the heart.

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing the use of Actizo 20/120 MG Tablet 8. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are some general guidelines for managing common side effects:

Nausea and vomiting: Taking Actizo 20/120 MG Tablet 8 with food or drinks like milk can help manage these symptoms.
Abdominal pain: Consider taking this medicine after meals to lessen the discomfort.

Actizo 20/120 MG Tablet 8 contains two active ingredients:

Artemether (20 mg): This ingredient swiftly decreases the number of malaria-causing parasites by hampering their ability to metabolise haemoglobin, a vital nutrient for their survival. Essentially, it targets the early stages of the parasite's life cycle.
Lumefantrine (120 mg): This component acts on the residual parasites that survive after the artemether's action. Due to its extended half-life, it works over a longer period and zeroes in on the later stages of the parasite's life cycle. By doing so, it prevents any relapse of malaria infection.

Pregnancy

Actizo 20/120 MG Tablet 8 is not recommended during the first trimester of pregnancy. If you are pregnant or planning to conceive, make sure to discuss this with your doctor before starting this medicine.

Breastfeeding

While breastfeeding, it's best to consult your doctor before taking Actizo 20/120 MG Tablet 8. Your doctor will advise you based on the benefits and risks involved.

Alcohol

It's best to consult your doctor for advice on this matter.

Liver

Actizo 20/120 MG Tablet 8 should be used with caution if you have liver problems, as this medicine is metabolised by the liver. Discuss your liver health with your doctor before starting this medicine.

Kidney

Actizo 20/120 MG Tablet 8 is excreted by the kidneys. If you have kidney issues, consult your doctor before taking this medicine.

Using Machines & Driving

Actizo 20/120 MG Tablet 8 may cause side effects such as dizziness or fatigue, which may affect your ability to drive or use machines. It's best not to drive or operate heavy machinery until you know how this medicine affects you.

Allergy

If you have a history of allergies, especially to antimalarial medicines, inform your doctor before starting the Actizo 20/120 MG Tablet 8.

Children

Caution is advised while giving Actizo 20/120 MG Tablet 8 to children under 18 years of age. Always consult your doctor before giving any medicine to a child.

Older Patients

Older patients should take Actizo 20/120 MG Tablet 8 under medical supervision. They may be more susceptible to its side effects and might also have liver and kidney issues. Your doctor will guide you based on your health status.

Interactions of Actizo 20/120 MG Tablet 8

Drug-Drug Interactions

Actizo 20/120 MG Tablet 8 interacts with the following medicines:

Antiarrhythmics: Medicines such as quinidine, procainamide, and amiodarone can interact with Actizo 20/120 MG Tablet 8, potentially increasing the risk of QT prolongation, which could lead to irregular heart rhythms.
Antipsychotics: Medicines like haloperidol, risperidone, and ziprasidone, when taken with Actizo 20/120 MG Tablet 8, may increase the risk of side effects like QT prolongation.
Antibiotics: Medicines such as erythromycin, rifampin, and clarithromycin could interact with Actizo 20/120 MG Tablet 8, altering its effectiveness or increasing side effects.
Anticonvulsants: Carbamazepine and phenytoin may interact with Actizo 20/120 MG Tablet 8, possibly altering its effectiveness.
Antidepressants: Medications like amitriptyline and imipramine can have interactions with this medicine that might require dose adjustments or alternative medications.
Hormonal contraceptives: The medications may reduce the efficacy of hormonal contraceptives.
Antifungals, such as ketoconazole
Antiretroviral medicines: The concomitant use of HIV protease inhibitors and non-nucleoside reverse transcriptase inhibitors with Actizo 20/120 MG Tablet 8 may increase the risk of side effects like QT prolongation.

Drug-Food Interactions

Grapefruit or grapefruit juice should be avoided while taking Actizo 20/120 MG Tablet 8 as it could increase the risk of side effects.

Drug-Disease Interactions

Actizo 20/120 MG Tablet 8 interacts with the following diseases:

Cardiac Arrhythmias: Patients diagnosed with cardiac arrhythmias should use Actizo 20/120 MG Tablet 8 cautiously as it could exacerbate their condition.
Liver or Kidney Impairment: The medicine is metabolised by the liver and excreted by the kidneys, hence patients with liver or kidney impairment should be cautious while taking this medication.

Daily Dose

The Actizo 20/120 MG Tablet 8 should be consumed as directed by your doctor. The dosage can vary depending on factors like how serious your condition is and how well you respond to the medicine. Always adhere to the prescribed dosage, and never increase it without consulting your doctor.

Over Dose

If you accidentally take more Actizo 20/120 MG Tablet 8s than recommended, you might experience an intensification of common side effects, particularly palpitations and nausea. If these symptoms persist or worsen, inform your doctor.

Missed Dose

If you forget to take your dose of Actizo 20/120 MG Tablet 8, take it as soon as you remember. However, if it's almost time for your next dose, skip the missed one and go back to your usual schedule. Don't increase your dosage without consulting your doctor.

Store Actizo 20/120 MG Tablet 8 in its original packing to maintain its efficacy.
Store at 20ºC to 25ºC (68ºF to 77ºF); excursions permitted to 15ºC to 30ºC (59ºF to 86ºF).
Choose a dry location away from direct light and moisture to avoid product degradation.
Keep this medicine far from the reach of children for safety reasons.
Always check the expiry date before using the medication; consuming expired medication may not work effectively and can cause harm.

Since malaria is transmitted by mosquitoes, use mosquito nets and repellents, especially during evening and night hours, to prevent bites.
Drink plenty of water to maintain good hydration. This helps flush out toxins from your body and manage possible side effects like nausea or vomiting.

Fact Box

Drug Category	Antimalarial Agents
Therapeutic Category	Antimalarial Medicine
Available Dosage Types	Tablet
Habit Forming	No
Ailment	Uncomplicated Plasmodium falciparum Malaria

What Is Actizo 20/120 MG Tablet 8 Used For?

Actizo 20/120 MG Tablet 8 is used to manage uncomplicated malaria caused by Plasmodium falciparum, particularly when other antimalarial medicines do not work.

How Does Actizo 20/120 MG Tablet 8 Work?

The medicine works by directly targeting malaria-causing parasites in your blood, inhibiting their growth and reproduction, thereby managing the infection.

Can I Take Actizo 20/120 MG Tablet 8 If I Am Allergic To Artemether or Lumefantrine?

No, if you have known hypersensitivity to artemether or lumefantrine, you should avoid taking this medicine. Please consult your doctor for alternatives.

Can Pregnant Women Take This Medicine?

Pregnant women, especially in the first trimester, should only use Actizo 20/120 MG Tablet 8 if the benefits justify the potential risks. Always consult your doctor first.

What Are Some Common Side Effects Of Actizo 20/120 MG Tablet 8?

Common side effects can include headache, dizziness, fatigue, nausea, vomiting, abdominal pain, anorexia, joint pain, palpitations, and skin rash.

What Precautions Should I Take While Using This Medicine?

Use with caution if you have liver or kidney impairment. Avoid grapefruit and grapefruit juice during medication. Always let your doctor know about any allergies or medications you're on.

What Should I Do In Case Of An Overdose?

In case of an overdose, seek immediate medical help. Symptoms may include exacerbated side effects like irregular heartbeats and fainting. There is no information on overdoses of Actizo 20/120 MG Tablet 8 SR higher than the doses recommended for treatment.

Certified Content

Written by

Ashmita Borgohain

Medical Content Writer & Editor | 12 years

MSc (Applied Genetics)

Reviewed by

Dr. Chhavi Rosha

Health & Medical Content Writer | 8 years

BMS, FMC, MD Resident

Check out Editorial Policy

Manufacturer details

A-41 Industrial Area Phase VIII-A SAS Nagar PB 160071 IN ,

Country of origin: INDIA

References

Novartis Pharmaceuticals Corporation. (2019). HIGHLIGHTS OF PRESCRIBING INFORMATION [Prescribing information]. https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/022268s021lbl.pdf
Chilipi, K. K., Kappel, J., Thomas, Y., & Novartis. (2018). Regulatory Affairs COARTEM (artemether/lumefantrine) 20 mg/120 mg, 80 mg/480 mg Tablets International Package Leaflet [Book]. Novartis. https://rwandafda.gov.rw/wp-content/uploads/2024/02/Coartem_20_120mg_Artemether_20mg_and%20Lumefantrine_120mg_tablets_PIL.pdf
Artemether: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB06697
Lumefantrine: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB06708
PubChem. (n.d.). Artemether. PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/68911
PubChem. (n.d.). Lumefantrine. PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/Lumefantrine

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