Vortioxetine
Uses of Vortioxetine
Vortioxetine is primarily used to manage major depressive disorder (MDD) in adults and belongs to the group of antidepressant medications called serotonin modulators and stimulators (SMS).
Side effects of Vortioxetine
Nausea and vomiting
Constipation
Abdominal pain
Dizziness
Fatigue and drowsiness
How Vortioxetine works
Vortioxetine is a serotonin modulator and stimulator.
It starts its work by inhibiting the reuptake of serotonin, which leads to an increase in serotonin levels in the brain. It binds to 5-HT1A receptors and activates them, thus enhancing serotonergic transmission. This medicine also partially activates 5-HT1B receptors to control the release of serotonin. Vortioxetine is an antagonist at 5-HT3, 5-HT1D, and 5-HT7 receptors. By acting on serotonin and other neurotransmitters like norepinephrine, dopamine, histamine, and acetylcholine, Vortioxetine brings about its antidepressant effects.
Certified content
Written By
BDS, MDS
Reviewed By
BMS, FMC, MD Resident
Expert Advice
Dosage forms available
- Vortioxetine is available as oral tablets for administration.
Age and dose restrictions
- Vortioxetine is intended for the management of major depressive disorder in adult patients.
Contraindications
- Vortioxetine is contraindicated in individuals with a known hypersensitivity to the active substance or any of the excipients in the product.
Other medications to avoid with this medicine
- Vortioxetine can interact with other serotonergic medications (such as, selective serotonin reuptake inhibitors like fluoxetine and sertraline, serotonin-norepinephrine reuptake inhibitors such as venlafaxine), and certain types of painkillers (such as nonsteroidal-anti-inflammatory drugs like ibuprofen).
- It is also contraindicated in patients who are currently taking monoamine oxidase inhibitors (MAOIs), like phenelzine or selegiline, or have taken MAOIs within the last 14 days due to an increased risk of serotonin syndrome.
Overdose and missed dose
- Overdose of Vortioxetine may lead to an increase in usual side effects such as nausea, vomiting, and dizziness. In case of an overdose, seek immediate medical assistance.
- If you miss a dose of Vortioxetine, take it as soon as you remember. However, if it is near the time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed dose.
Management of side effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
- If you experience nausea or upset stomach, it may help to take Vortioxetine with food.
- Keep yourself well-hydrated to help manage dry mouth.
Use in driving and operating machinery
- Vortioxetine may cause side effects like dizziness or fatigue, affecting your ability to drive or operate machinery. Therefore, avoid such activities until you know how this medication affects you.
Use in pregnancy and lactation
- The use of Vortioxetine during pregnancy and lactation should only be if the potential benefits outweigh the potential risks. Always consult your doctor before using this medication if you are pregnant or breastfeeding.
Caution in other conditions
- Caution should be exercised in patients with a history of mania or seizures, as Vortioxetine may worsen these conditions.
- Patients with bleeding disorders should also use Vortioxetine with caution due to an increased risk of abnormal bleeding.
Special dietary and lifestyle recommendation
- Regular physical activity can help manage depression symptoms. Aim to incorporate moderate exercise into your routine on most days of the week.
- A balanced diet of fruits, vegetables, lean proteins, and whole grains can support overall health and well-being.
- Maintaining a regular sleep schedule to ensure adequate rest and recovery is also beneficial.
- Reducing caffeine and alcohol intake may also aid in managing symptoms of depression.
Frequently asked questions
I heard Vortioxetine is an antidepressant. Is it the same as SSRIs and SNRIs?
No, Vortioxetine is not the same as SSRIs (serotonin reuptake inhibitors) or SNRIs (serotonin-norepinephrine reuptake inhibitors). It belongs to a unique class of medications known as serotonin modulators and stimulators (SMS). While both of these classes of medications work to manage major depressive disorder, Vortioxetine has a unique method of action.
Does Vortioxetine have any impact on cognitive function?
Yes, Vortioxetine may have a positive impact on cognitive functions such as thinking, remembering, and problem-solving. This is due to its unique action on various neurotransmitters in the brain, including serotonin.
Can Vortioxetine cause dependency or addiction?
Vortioxetine is not known to cause dependency or addiction. However, it should be taken exactly as prescribed by your doctor and should not be stopped abruptly without medical advice due to the risk of withdrawal symptoms.
Are there non-pharmaceutical alternatives to Vortioxetine for managing depression?
While medications like Vortioxetine can be very effective for managing major depressive disorder, they are typically used in conjunction with other treatments such as psychotherapy or counselling. Lifestyle changes, such as regular physical activity and a healthy diet, can also support overall mental health.
How long should I expect to take Vortioxetine?
The duration of therapy with Vortioxetine varies from person to person depending on their response and the severity of their symptoms. It is typically used long-term to maintain control of symptoms.
If I am allergic to certain medicines, could I be allergic to Vortioxetine too?
Allergy to one medication does not necessarily mean you will be allergic to others. However, if you have had allergic reactions to medicines in the past, make sure to inform your doctor. They can decide whether Vortioxetine is the right medicine for you.
Are there any specific foods or drinks I should avoid while taking Vortioxetine?
While Vortioxetine does not usually interact with food, it is recommended to limit alcohol intake as it may exacerbate certain side effects like nausea and dizziness.
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