Ulipristal Acetate
Uses of Ulipristal Acetate
Ulipristal Acetate is primarily used for the management of moderate to severe symptoms of uterine fibroids in adult women of reproductive age. It comes under the class of selective progesterone receptor modulators.
Additionally, it serves as an emergency contraceptive to prevent pregnancy following unprotected sexual intercourse or a known or suspected contraceptive failure.
Side effects of Ulipristal Acetate
Headache
Nausea and vomiting
Abdominal pain
Fatigue and dizziness
Absence of menstrual periods (amenorrhea)
How Ulipristal Acetate works
Ulipristal Acetate is a selective progesterone receptor modulator.
It works by binding to progesterone receptors and inhibiting the effects of progesterone. This action prevents or delays ovulation by disrupting the hormonal signals required for follicle maturation and release. Additionally, it alters the endometrium, reducing its receptivity to implantation, which contributes to its effectiveness as an emergency contraceptive.
Certified content
Written By
Doctor of Medicine
Reviewed By
BMS, FMC, MD Resident
Expert Advice
Dosage Forms Available
Ulipristal Acetate is available for oral administration in the form of tablets.
Age and Dose Restrictions
This medicine is intended for use in adult women of reproductive age.
It is not recommended for use in children or men.
Contraindications
Ulipristal Acetate is contraindicated in individuals with known or suspected pregnancy.
It is also contraindicated in patients with undiagnosed abnormal genital bleeding and known or suspected breast cancer or other hormone-sensitive malignancies.
Other Medications to Avoid
Ulipristal Acetate may interact with anticonvulsants (such as phenytoin, carbamazepine) and antifungals (such as ketoconazole, itraconazole).
It's also advised to avoid hormonal contraceptives when using Ulipristal Acetate.
Overdose and Missed Dose
Overdose of Ulipristal Acetate can cause severe nausea and vomiting. If you experience these symptoms after taking more than the recommended dose, contact your doctor immediately.
If you miss a dose of Ulipristal Acetate, take it as soon as you remember. If it's almost time for your next dose, skip the missed dose and continue with your regular dosing schedule.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
Drinking plenty of water can help manage side effects such as nausea and vomiting.
Resting and avoiding strenuous activities can help manage fatigue and dizziness.
Wearing light, comfortable clothing can help manage hot flushes and sweating.
Use in Driving and Operating Machinery
Ulipristal Acetate may cause dizziness and fatigue, affecting your ability to drive or operate machinery. Avoid such activities if you experience these side effects.
Use in Pregnancy and Lactation
Ulipristal Acetate is not recommended for use in a pregnancy that you want to preserve or during breastfeeding. Inform your doctor if you are pregnant or breastfeeding before starting this medication.
Caution in Other Conditions
Patients with liver diseases should use Ulipristal Acetate with caution as it can cause elevated liver enzymes.
Caution should also be exercised in patients with a history of blood clots due to the hormone-modulating effects of Ulipristal Acetate.
Special Dietary and Lifestyle Recommendations
Maintain a balanced diet rich in iron to manage potential anaemia due to heavy menstrual bleeding in case of uterine fibroids.
Regular, light physical activity can help improve overall health and wellbeing.
Limit alcohol consumption as it can potentially worsen liver function in individuals taking Ulipristal Acetate.
Adequate rest and sleep are important to manage potential tiredness or fatigue associated with this medicine.
Frequently asked questions
Is Ulipristal Acetate a steroid?
No, Ulipristal Acetate is not a steroid. It belongs to the class of medicines known as selective progesterone receptor modulators.
Does Ulipristal Acetate have any effect on sleep?
No known direct effects on sleep have been reported with the use of Ulipristal Acetate. However, side effects such as dizziness and fatigue may indirectly impact sleep patterns.
Will Ulipristal Acetate affect fertility?
Ulipristal Acetate can temporarily delay ovulation, which might impact fertility. However, these effects are reversible, and the medicine does not have a long-term impact on a woman's fertility.
Are there any particular diet restrictions while taking Ulipristal Acetate?
There are no specific diet restrictions while taking Ulipristal Acetate unless specified by a doctor.
Is it safe to take Ulipristal Acetate daily?
Ulipristal Acetate should only be taken as per the instructions of a doctor. For managing uterine fibroids, it is usually taken for longer durations.
How much time does Ulipristal Acetate take to work?
As an emergency contraceptive, Ulipristal Acetate should be taken within 120 hours (5 days) of unprotected intercourse. It is most effective when taken within the first 24 hours.
What is the best time to take Ulipristal Acetate?
The best time to take Ulipristal Acetate will depend on its purpose of use and should be decided by the doctor.
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