Tranexamic Acid
ANTI-FIBRINOLYTIC CATEGORYUses of Tranexamic Acid
- Tranexamic acid is used to prevent and treat bleeding in various conditions, including heavy menstrual bleeding in women, gastrointestinal bleeding, hemorrhagic urinary disorders, post-operative bleeding, and bleeding following blood clot treatments.
- It may be used by teenage females but is not intended for use before the onset of menstruation.
Side effects of Tranexamic Acid
- Feeling sick
- Being sick
- Diarrhoea
How Tranexamic Acid works
Tranexamic Acid is an antifibrinolytic agent that prevents blood clot breakdown. It works by binding to the lysine binding sites of plasminogen, which is responsible for the breakdown of fibrin, a protein essential for blood clot formation. By inhibiting the action of plasminogen, it helps stabilise blood clots and prevent excessive bleeding. In menstrual bleeding, it is thought to reduce bleeding by inhibiting the breakdown of fibrin in the lining of the uterus.
Certified content
Written By
B. Pharm
Reviewed By
B. Pharm, MSc.
Expert Advice
Dosage Forms Available
- Tablet and Injection.
Age and Dose Restrictions
- It is intended for adults and children above one year of age.
Contraindications
- It is contraindicated in patients with a history of hypersensitivity to Tranexamic Acid and patients with renal insufficiency, currently having blood clots or disease leading to blood clots, consumption coagulopathy, and a history of convulsions.
Other Medications To Avoid With This Medicine
- Avoid taking other anti-fibrinolytic medicines (aprotinin), thrombolytic medicines (streptokinase), and oral contraceptives (ethinylestradiol). These medications may alter the safety and effectiveness of Tranexamic Acid.
Overdose and Missed Dose
- Overdose can cause dizziness, headache, nausea, vomiting, diarrhoea, orthostatic symptoms hypotension and convulsions. These symptoms need to be managed as an emergency in a hospital setting. Therefore, strict adherence to the prescribed dose is essential.
- If you miss a dose of Tranexamic Acid, take it as soon as you remember. But, if the next dose is near, skip the missed dose and resume the regular dosing regime.
Use In Driving And Operating Machinery
- It does not affect the ability to drive or operate machinery.
Use in Pregnancy and Lactation
- Caution is advised in pregnancy. It is not recommended during breastfeeding.
Caution In Other Conditions
- Caution is advised in older adults and in patients who have had blood in their urine.
Special Dietary & Lifestyle Recommendation
- Consume a well-balanced diet rich in fruits, vegetables, whole grains, lean proteins, and healthy fats.
- Incorporate iron-rich foods, such as spinach, lentils, lean red meat, and fortified cereals, to support blood production.
- Limit or avoid foods that can thin the blood or increase bleeding, such as excessive garlic, ginger, turmeric, and omega-3 fatty acid supplements.
- Follow a low-sodium diet to help maintain optimal blood pressure levels.
- Limit the intake of processed and packaged foods, often high in sodium.
- Engage in regular exercise, such as walking or swimming, to help manage blood pressure.
- Maintain good oral hygiene habits, including regular brushing, flossing, and dental check-ups.
- Avoid taking alcohol with this medication to avoid the risk of side effects.
Frequently asked questions
How long does Tranexamic Acid take to stop bleeding?
It shows its effects within a few hours after administration. The time it takes to stop bleeding varies depending on the individual and the specific condition being treated.
Is Tranexamic Acid considered safe?
It is generally considered safe when used as prescribed by a doctor. However, it is contraindicated in patients with deep vein thrombosis, pulmonary embolism, kidney problems, brain haemorrhage, visual defects, and seizures.
Can you take Tranexamic Acid on an empty stomach?
It is generally recommended to be taken with food to reduce the risk of stomach upset or irritation.
Does Tranexamic Acid affect fertility?
It is not known to affect fertility in either males or females. It is an antifibrinolytic medication primarily used to control bleeding, and its mechanism of action does not interfere with fertility or reproductive functions.
Can Tranexamic Acid cause pulmonary embolism?
It is not known to cause a pulmonary embolism directly.
Can Tranexamic Acid be used for piles?
It is not typically used to treat piles (haemorrhoids).
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