Tizanidine
Uses of Tizanidine
The primary use of Tizanidine is in the management of spasticity associated with conditions such as multiple sclerosis, spinal cord injuries, and stroke. It belongs to the group of skeletal muscle relaxants.
Secondary uses of Tizanidine include off-label applications for conditions such as migraines, insomnia, and rebound headaches associated with analgesic withdrawal.
Side effects of Tizanidine
Dry mouth
Drowsiness
Weakness
Dizziness
Urinary tract infections
How Tizanidine works
Tizanidine is a skeletal muscle relaxant. It operates by acting as an α2-adrenergic agonist. To put it simply, it works on the brain and spinal cord to slow down nerve signals that cause muscle spasticity and spasms. Further, it reduces the release of certain chemicals in the body called excitatory amino acids which are involved in causing spasms and spasticity.
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Written By
Bachelor of Dental Surgery
Reviewed By
Doctor of Medicine
Expert Advice
Dosage Forms Available
Tizanidine is available in the form of oral tablets and capsules.
Age and Dose Restrictions
The use of Tizanidine is approved for adults of age above 18 years
Contraindications
It is contraindicated in patients with known hypersensitivity to tizanidine.
Other Medications to Avoid
Tizanidine may interact with potent inhibitors of CYP1A2 (such as fluvoxamine or ciprofloxacin), beta-blockers (such as metoprolol and bisoprolol), angiotensin-converting enzyme (ACE) inhibitors (like lisinopril and perindopril), and benzodiazepines (like diazepam and alprazolam).
Overdose and Missed Dose
An overdose of Tizanidine may lead to symptoms such as extreme tiredness, weakness, slurred speech, slow heartbeat, difficulty breathing, and even loss of consciousness. If you suspect an overdose, contact your doctor immediately.
In case you forget a dose, take it as soon as you remember it. But if it's almost time for your next dose, then skip the missed dose and return to your regular dosing schedule.
Management of Side Effects
Most side effects will resolve once you discontinue Tizanidine. However, if severe side effects or worsening of symptoms occur, consult your doctor.
Drinking plenty of water can help manage constipation.
Resting or lying down can assist with managing feelings of dizziness or fatigue.
Use in Driving and Operating Machinery
Tizanidine may impair your ability to drive or operate heavy machinery. It is advised to avoid such activities if you feel drowsy or dizzy after taking this medicine.
Use in Pregnancy and Lactation
The use of this medicine during pregnancy and breastfeeding should only be considered if the potential benefit outweighs the possible risk. Consult your doctor before using this medicine if you are pregnant or breastfeeding.
Caution in Other Conditions
People with liver disease or kidney disease should be cautious while using Tizanidine. Your doctor may need to adjust your dose based on your condition.
Special Dietary and Lifestyle Recommendations
Regular physical therapy can help in managing the muscle spasms and stiffness associated with the conditions Tizanidine is used to manage.
Consumption of a balanced diet rich in vitamins and minerals may support overall health.
Adequate rest and good sleep hygiene may also aid in managing symptoms associated with neurological conditions.
Frequently asked questions
Is Tizanidine a painkiller?
No, Tizanidine is not a painkiller. It is a skeletal muscle relaxant used to manage muscle spasms and spasticity.
Can Tizanidine cause weight gain?
Not typically. Weight gain is not listed as a common side effect of Tizanidine. However, everyone responds differently to medicine and if you notice any major changes in your body weight, consult your doctor.
Does Tizanidine have any effect on mood?
Some patients taking Tizanidine have reported experiencing mood changes, including increased anxiety and depression. If you notice any changes in your mood, inform your doctor immediately.
Can I suddenly stop taking Tizanidine?
No, do not suddenly stop taking Tizanidine without consulting your doctor first. Abrupt discontinuation can lead to rebound symptoms such as increased heart rate and high blood pressure.
Does Tizanidine have any effect on the menstrual cycle?
No, Tizanidine does not have any effect on the menstrual cycle.
Does Tizanidine have any effect on sleep?
Yes, Tizanidine can potentially cause drowsiness or somnolence, which might impact your sleep. This is considered a common side effect of the medication.
Will Tizanidine affect fertility?
Tizanidine is not associated with affecting fertility. However, if you have concerns about this, you should consult your doctor.
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