Tigecycline
Uses of Tigecycline
- Tigecycline is primarily used to manage susceptible bacterial infections such as complicated skin and skin structure infections, complicated intra-abdominal infections, and community-acquired bacterial pneumonia in adults and children above 18 years of age. It is a glycylcycline antibiotic.
Side effects of Tigecycline
Nausea
Vomiting
Diarrhoea
Abdominal pain
Headache
How Tigecycline works
Tigecycline is a broad-spectrum glycylcycline antibiotic.
It works by blocking the production of essential proteins that bacteria need to grow and multiply. Specifically, it targets a part of the bacterial cell machinery called the 30S ribosomal subunit. Tigecycline binds to this subunit, stopping the bacteria from making the proteins they need. Without these proteins, the bacteria can't grow or spread, helping to control the infection.
Certified content
Written By
BDS, MDS
Reviewed By
Bachelor of Dental Surgery
Expert Advice
Dosage Forms Available
Tigecycline is available in injection form and it can be administered intravenously (lyophilised (freeze-dried) powder solution for injection).
Age and Dose Restrictions
Tigecycline is intended for use in adults and children over the age of 18.
Contraindications
Tigecycline is contraindicated in individuals who have a known hypersensitivity to Tigecycline or any other tetracycline antibiotics.
Other Medications to Avoid
Tigecycline may interact with anticoagulants (eg., warfarin), and contraceptives (eg., desogestrel, ethinyl estradiol).
Overdose and Missed Dose
Overdosage is unlikely as it is administered by a healthcare professional. An overdose of Tigecycline can lead to an exacerbation of its side effects such as nausea, and vomiting. If you suspect an overdose, seek immediate medical attention.
If you miss a dose of Tigecycline, Consult your doctor for the next dose.
Management of Side Effects
Most side effects are temporary, generally harmless, and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
If you experience a headache, you may use a regular over-the-counter painkiller, but consult your doctor before doing so.
In case of diarrhoea, ensure to keep hydrated by drinking plenty of fluids.
Use in Driving and Operating Machinery
Tigecycline can cause dizziness or confusion in some people. If you experience these effects, avoid driving or operating heavy machinery until you feel well again.
Use in Pregnancy and Lactation
Tigecycline may cause harm to the fetus when administered to a pregnant woman. Therefore, it is important to consult your doctor if you are pregnant or plan to become pregnant while on this medication. Nursing mothers should discuss this with their doctor before administering this medication.
Caution in Other Conditions
Patients with severe hepatic (liver) impairment should exercise caution when taking Tigecycline and a reduced maintenance dose may be required.
Patients with known hypersensitivity to other tetracycline-class antibiotics should also exercise caution while taking this medication.
Special Dietary and Lifestyle Recommendations
Adequate hydration is crucial for eliminating toxins from the body, so ensure to drink plenty of fluids.
Frequently asked questions
Is Tigecycline a steroid?
No, Tigecycline is not a steroid. It is an antibiotic that belongs to the glycylcycline class of medications.
How long does it take for Tigecycline to start working?
Tigecycline starts working soon after administration but the time taken for you to start feeling better could vary depending on the type of infection. It is crucial to follow your doctor's instructions and complete the course of medication, even if you start feeling better before finishing the prescribed course.
Can Tigecycline affect my mood or behaviour?
No such effects of Tigecycline on mood or behaviour have been reported. However, if you experience any changes in your mood or behaviour after starting this medication, consult your doctor immediately.
Does Tigecycline have any impact on menstruation?
If you notice any changes in your menstrual pattern, consult your doctor.
Are there any natural alternatives to Tigecycline?
There are no known natural alternatives that have the same broad-spectrum antibiotic capabilities as Tigecycline. It is always best to consult your doctor for advice on managing serious bacterial infections.
Can Tigecycline cause allergies?
Yes, allergic reactions to Tigecycline may occur, particularly in individuals who have a known hypersensitivity to tetracycline-class antibiotics. Signs of an allergic reaction can include itching, rash, swelling, severe dizziness, or trouble breathing.
Is there a vegetarian alternative to Tigecycline?
Tigecycline itself does not contain animal-derived ingredients and thus is suitable for vegetarians and vegans. However, you should always check with your pharmacist or doctor if you have specific dietary needs or concerns.
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