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Tetrabenazine

Uses of Tetrabenazine

  • Tetrabenazine is primarily used to manage chorea, which are abnormal involuntary movements associated with Huntington's disease. It falls under the category of medicines known as vesicular monoamine transporter 2 (VMAT2) inhibitors.

  • Apart from managing chorea in Huntington's disease, Tetrabenazine may also be used off-label to manage other movement disorders, such as tics in Tourette's syndrome, upon the advice of a doctor.

Side effects of Tetrabenazine

  • Drowsiness

  • Sedation

  • Depression

  • Nausea and Vomiting

  • Difficulty swallowing

How Tetrabenazine works

  • Tetrabenazine is a vesicular monoamine transporter 2 (VMAT2) inhibitor.

  • It operates by reducing the amount of certain neurotransmitters in your brain. Neurotransmitters are chemicals that nerves use to communicate with each other. Tetrabenazine specifically targets neurotransmitters such as dopamine, serotonin, norepinephrine, and histamine.

Certified content

Written By

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Dr. Michelle FrankMedical Content Writer| 8 years

Doctor of Medicine

Reviewed By

Dr. Chhavi Rosha
Dr. Chhavi Rosha Health & Medical Content Writer| 8 years

BMS, FMC, MD Resident

Expert Advice

Dosage Forms Available

  • Tetrabenazine is available for use via the oral route in the form of tablets.

Age and Dose Restrictions

  • This medicine is meant for adults of age above 18 years.

Contraindications

  • Tetrabenazine is contraindicated in patients who are actively suicidal or have untreated or inadequately treated depression.

  • This medicine is also contraindicated in patients who are taking monoamine oxidase inhibitors (MAOIs) or reserpine.

Other Medications to Avoid

  • Tetrabenazine may interact with several medications, including antidepressants (such as fluoxetine or sertraline), antipsychotics (like risperidone), and other medications that affect serotonin levels (such as tramadol).

Overdose and Missed Dose

  • An overdose of Tetrabenazine may cause symptoms such as drowsiness, sedation, hypotension, tachycardia, and extrapyramidal symptoms. If you observe any of these symptoms, inform your doctor immediately.

  • If you forget to take your dose of Tetrabenazine, take it as soon as you remember. However, skip the missed dose if it is almost time for your next dose. Do not double your dose to make up for the missed one.

Management of Side Effects

Most side effects of Tetrabenazine are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

  • If you experience drowsiness or sedation, try taking your dose at bedtime.

  • For nausea or vomiting, try taking your dose with a light snack or meal.

  • Stay hydrated to help manage dizziness or lightheadedness.

Use in Driving and Operating Machinery

  • Tetrabenazine may cause sedation and drowsiness, which can impair your ability to drive or operate heavy machinery. Avoid these activities if you feel dizzy or sleepy after taking this medicine.

Use in Pregnancy and Lactation

  • The use of Tetrabenazine during pregnancy and breastfeeding is not recommended unless advised by your doctor. Consult your doctor if you are pregnant, planning to conceive, or breastfeeding.

Caution in Other Conditions

  • Tetrabenazine should be used with caution in patients with liver impairment, as it is extensively metabolized by the liver. Regular monitoring of liver function may be necessary while taking this medicine.

  • It should also be used with caution in patients with a history of QT prolongation or other heart problems, as Tetrabenazine may prolong the QT interval.

Special Dietary and Lifestyle Recommendations

  • Maintain a balanced diet to support overall health and well-being.

  • Regularly engage in physical activity to improve cardiovascular health and mobility.

  • Practice relaxation and mindfulness techniques to help manage anxiety or depression associated with Huntington's disease.

Frequently asked questions

Tetrabenazine may affect mood and can sometimes lead to depression and anxiety. It is essential to notify your doctor if you experience any significant mood changes.

No, Tetrabenazine is not classified as a controlled substance; it is a prescription medication used to manage chorea associated with Huntington's disease.

The common side effects of Tetrabenazine do not directly mention weight gain. However, some associated side effects like fatigue and sedation may indirectly alter physical activity levels and dietary habits, which could lead to weight changes.

It is not advisable to stop taking any prescribed medication abruptly without consulting your doctor as it might lead to withdrawal symptoms or recurrence of symptoms.

No, Tetrabenazine is not a steroid. It is a medication used for managing symptoms of certain neurological conditions.

Yes, Tetrabenazine can cause drowsiness, sedation, and insomnia in some individuals.

The time taken for Tetrabenazine to show its effect can vary among individuals based on factors such as the severity of symptoms and individual response to medication. Please consult your doctor for more information.

Terms & Conditions

Available medicines for TETRABENAZINE
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