Terlipressin
Uses of Terlipressin
The main use of Terlipressin is for the management of bleeding esophageal varices and hepatorenal syndrome type 1 (HRS-1). It belongs to the class of vasopressin analogs.
Side effects of Terlipressin
Abdominal pain
Nausea
Diarrhea
Respiratory failure
Fluid overload
How Terlipressin works
Terlipressin functions by activating specific receptors, called V1 receptors, on the muscle cells of our blood vessels. This activation causes these muscles to tighten, leading to narrowing or constricting of the blood vessels.
Certified content
Written By
Bachelor of Dental Surgery
Reviewed By
MSc (Applied Genetics)
Expert Advice
Dosage Forms Available
Terlipressin is available in the form of a powder for solution to be administered intravenously.
Age and Dose Restrictions
Terlipressin is meant for adult use only.
Contraindications
Terlipressin is contraindicated in patients with a known hypersensitivity to this medicine. It is also contraindicated in patients with coronary artery disease, heart failure, bronchial asthma, or uncontrolled hypertension due to the risk of ischaemic complications.
Other Medications to Avoid
Terlipressin may interact with antihypertensive medications (e.g., lisinopril, amlodipine), and diuretics (e..g, furosemide, hydrochlorothiazide).
Overdose and Missed Dose
An overdose of Terlipressin can cause serious side effects like chest pain, irregular heartbeat, or seizures. If you observe any of these symptoms, inform your doctor and follow their advice accordingly.
If you forget to administer this medicine, do it as soon as you remember. But avoid repeating the dose.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing Terlipressin. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
Drinking plenty of water can help manage some side effects, such as nausea and diarrhea.
For abdominal pain, lying down and resting can provide relief.
Try taking this medication with food if it causes stomach upset.
Use in Driving and Operating Machinery
Terlipressin may cause dizziness; therefore, it can affect your ability to drive or operate heavy machinery. Avoid these activities if you feel dizzy after taking this medicine.
Use in Pregnancy and Lactation
Terlipressin should be used during pregnancy only if the benefits justify the potential risks. It is unknown if Terlipressin is excreted in breast milk. Consult your doctor before using this medicine during pregnancy and breastfeeding.
Caution in Other Conditions
Patients with liver or kidney conditions should exercise caution when taking Terlipressin.
Special Dietary and Lifestyle Recommendations
Reduce intake of salt as it can exacerbate fluid retention and edema associated with liver disease.
Limit alcohol consumption as it can worsen liver damage.
Avoid smoking as it can increase the risk of esophageal varices.
Frequently asked questions
Is Terlipressin a steroid?
No, Terlipressin is not a steroid. It is a synthetic analog of vasopressin, a hormone that helps regulate the body's water balance.
Does the Terlipressin have any effect on sleep?
There is no direct mention of Terlipressin affecting sleep in the available scientific literature. However, if you experience any sleep disturbances after taking this medication, you should consult your doctor.
Will Terlipressin affect fertility?
Currently, there is no evidence to suggest that Terlipressin can directly affect fertility. If you have any concerns about fertility and the use of this medicine, you should discuss them with your doctor.
Are there any particular diet restrictions while taking Terlipressin?
There are no specific food restrictions for those taking Terlipressin. However, maintaining a balanced diet is always beneficial for overall health. It is advisable to consult your doctor if you have specific dietary concerns.
Is it safe to take Terlipressin daily?
Terlipressin should be taken as prescribed by your doctor. The frequency and duration of use will depend on the condition it is being used to manage.
How much time does Terlipressin take to work?
For hepatorenal syndrome type 1 (HRS-1), improvement in renal function is usually seen within 3-7 days of starting treatment. For variceal bleeding, hemostasis is typically achieved within 48 hours.
What is the best time to take Terlipressin?
Terlipressin is administered by intravenous injection or infusion under medical supervision; therefore, the timing of administration will be decided by the healthcare professionals managing your condition.
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