Teriflunomide
Uses of Teriflunomide
The main use of Teriflunomide is for managing relapsing forms of multiple sclerosis (MS) in adults. It belongs to the class of disease-modifying therapies (DMTs).
It is also used in specific conditions associated with multiple sclerosis such as clinically isolated syndrome (CIS), relapsing-remitting MS (RRMS), and active secondary progressive MS (SPMS).
Side effects of Teriflunomide
Headache
Diarrhoea
Nausea
Hair thinning or hair loss
Elevated liver enzymes
How Teriflunomide works
Teriflunomide is a disease-modifying therapy for multiple sclerosis.
It works by selectively and reversibly blocking the action of an enzyme called dihydroorotate dehydrogenase (DHO-DH). This enzyme is crucial for the production of pyrimidine, a molecule that is necessary for cells to divide and multiply.
By inhibiting this enzyme, Teriflunomide reduces the multiplication of rapidly dividing cells, including certain types of white blood cells known as T-lymphocytes and B-lymphocytes. These cells are involved in the inflammatory process of multiple sclerosis.
By reducing the number of these inflammatory cells, Teriflunomide decreases inflammation in the central nervous system, which includes the brain and spinal cord. This helps in managing the symptoms of multiple sclerosis.
Certified content
Written By
Bachelor of Dental Surgery
Reviewed By
MSc (Applied Genetics)
Expert Advice
Dosage Forms Available
Teriflunomide is available for use via the oral route (tablet).
Age and Dose Restrictions
The medicine is intended for use in adults aged 18 years and above.
Contraindications
Teriflunomide is contraindicated in patients with known hypersensitivity to it.
Additionally, it should not be used by patients with severe hepatic impairment due to the potential for increased risk of liver injury.
Other Medications to Avoid
This medicine can interact with other hepatotoxic medicines (methotrexate), immunosuppressive or immunomodulating therapies (corticosteroids), medicines metabolised by CYP2C8 (such as paclitaxel) and BCRP transporters (rosuvastatin).
Overdose and Missed Dose
An overdose of Teriflunomide may lead to severe symptoms including abdominal pain, dizziness or fainting. If you suspect an overdose, seek immediate medical attention.
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the next dose at the regular time.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
Drinking plenty of water may help manage some of the minor gastrointestinal side effects like nausea and diarrhoea.
Resting or lying down may help manage feelings of dizziness or light-headedness.
Use in Driving and Operating Machinery
Teriflunomide may cause dizziness, therefore caution is advised while driving or operating heavy machinery after taking this medicine.
Use in Pregnancy and Lactation
Teriflunomide is not recommended for use in pregnancy and lactation. Women of childbearing potential must use effective contraception during and for a period of 2 years after treatment.
Caution in Other Conditions
Patients with pre-existing liver disease, hypertension, active infection, or a history of serious infection should exercise caution when taking Teriflunomide.
Additionally, patients with mild to moderate renal impairment should also be cautious when using this medicine.
Special Dietary and Lifestyle Recommendations
Engaging in regular physical activity can improve muscle strength and flexibility.
Avoid exposure to extreme temperatures as they can exacerbate symptoms.
Manage stress through relaxation techniques like meditation or yoga. Stress can potentially trigger MS symptoms.
Regular follow-ups with your doctor are recommended to monitor your progress and adjust the management plan as needed.
Frequently asked questions
Is Teriflunomide a steroid?
No, Teriflunomide is not a steroid. It is a disease-modifying therapy (DMT) used for the management of multiple sclerosis.
Can Teriflunomide affect my sleep pattern?
There are no direct indications that Teriflunomide affects sleep patterns. However, individual reactions to the medicine may vary. If you experience sleep disturbances after beginning this medication, consult your doctor.
Will taking Teriflunomide affect my fertility?
Please consult your doctor regarding concerns about fertility. Pregnant women are advised not to take this medicine due to the risk of birth defects. Women of childbearing potential must use effective contraception during and after treatment with Teriflunomide.
Can I take natural supplements while on Teriflunomide?
While some natural supplements may not interfere with Teriflunomide, it is recommended to consult your doctor before starting any new supplements alongside this medication.
Can I take Teriflunomide every day?
Teriflunomide is safe for daily use. However, always follow the dosage and schedule as prescribed by your doctor.
How long does it take for Teriflunomide to start working?
Teriflunomide may take several months to show full benefits. In clinical trials, effects were observed within 6-12 weeks of treatment. Results will vary according to individual conditions.
Can I buy Teriflunomide over the counter?
No, you cannot buy Teriflunomide over the counter; it requires a doctor's prescription.
Subscribe
Claim your complimentary health and fitness tips subscription and stay updated on our newest promotions.
Download Truemeds
Manage your health with ease Download Truemeds today!Get easy access to medicine refills, health information, and more. With our app, you'll never have to wait in line again. Download now and start taking control of your health.
Contact Us
Our customer representative team is available 7 days a week from 9 am - 9 pm.
v3.4.16
2024 - Truemeds | All rights reservedOur Payment Partners
