Tenofovir Alfenamide
Uses of Tenofovir Alfenamide
- Tenofovir Alafenamide is primarily used to manage chronic hepatitis B virus (HBV) infection and HIV-1 infection. It is a part of the antiviral medication group known as nucleotide reverse transcriptase inhibitors (NtRTIs).
Side effects of Tenofovir Alfenamide
- Headache
- Stomach pain
- Diarrhoea
- Fatigue
- Nausea
How Tenofovir Alfenamide works
- Tenofovir Alafenamide is a nucleotide reverse transcriptase inhibitor (NtRTI).
- Tenofovir Alafenamide starts as an inactive "prodrug" and is converted in the body to its active form, tenofovir diphosphate. This active form blocks key enzymes that HIV and hepatitis B viruses need to multiply, helping to lower the virus levels in your body. It's more efficiently absorbed by cells, allowing for lower doses and reducing the risk of kidney problems, making it a safer long-term treatment option.
Certified content
Written By
Doctor of Medicine
Reviewed By
BMS, FMC, MD Resident
Expert Advice
Dosage Forms Available
- Tenofovir Alafenamide is available in the form of oral tablets. This medicine is administered through the oral route.
Age and Dose Restrictions
- Tenofovir Alafenamide is prescribed for adults and for children who are at least 12 years old.
Contraindications
- Tenofovir Alafenamide should not be taken by individuals who are hypersensitive or allergic to it or any of its components.
Other Medications to Avoid
- Tenofovir Alafenamide can interact with other antiretroviral medication (such as lamivudine, efavirenz), medication for liver problems (such as rifampicin, rifabutin), and medication for kidney problems (like cimetidine, probenecid).
- Prior to starting any prescription, over-the-counter medications or supplements, it is important to consult your doctor.
Overdose and Missed Dose
- In case of an overdose of Tenofovir Alafenamide, immediate medical attention is necessary. Symptoms may include severe dizziness, fainting, or changes in heartbeat.
- If a dose is missed, it should be taken as soon as remembered. However, if it is close to the time for the next dose, the missed dose should be skipped. Do not double up on doses.
Management of Side Effects
Most side effects of Tenofovir Alafenamide are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any symptoms, please consult your doctor.
- Drinking plenty of fluids may help to manage certain side effects such as headaches.
- Resting and avoiding bright lights may help manage cases of dizziness.
- Eating bland foods and avoiding rich or spicy meals may help manage stomach related side effects.
Use in Driving and Operating Machinery
- Tenofovir Alafenamide may cause dizziness. Driving or operating machinery should be avoided if such side effects are experienced.
Use in Pregnancy and Lactation
- Tenofovir Alafenamide should only be used during pregnancy and breastfeeding if the potential benefit justifies the potential risk to the mother and child. It is always advisable to consult your doctor before use.
Caution in Other Conditions
- Caution should be exercised when using Tenofovir Alafenamide in patients with severe renal (kidney) impairment.
- Patients with liver problems should also exercise caution while taking this medicine.
Special Dietary and Lifestyle Recommendations
- Regular blood tests may be required to monitor your health while using Tenofovir Alafenamide.
- Always practice safe sex, even if you are taking medication for HIV or hepatitis B, to avoid passing the infection to others.
- Regular exercise can strengthen the immune system and improve overall health, which is beneficial for people with chronic infections such as hepatitis B or HIV.
Frequently asked questions
What is Tenofovir Alafenamide used for?
Tenofovir Alafenamide is mainly used to manage chronic hepatitis B virus (HBV) infection and HIV-1 infection. This medicine belongs to the class of antiviral medications known as nucleotide reverse transcriptase inhibitors (NtRTIs).
Can Tenofovir Alafenamide be taken daily?
Yes, Tenofovir Alafenamide is typically taken daily as prescribed by your doctor. Consistent daily use is important for effective management of HIV or hepatitis B.
Can Tenofovir Alafenamide cause liver problems?
Yes, severe liver problems are a potentially serious side effect of Tenofovir Alafenamide. It is important to monitor liver function regularly while using this medicine.
Does Tenofovir Alafenamide affect appetite or mood?
Tenofovir Alafenamide generally does not have a significant impact on appetite or mood. However, if you experience any unusual symptoms, including changes in appetite or mood, consult your doctor.
Can Tenofovir Alafenamide be taken by patients with kidney disease?
Tenofovir Alafenamide is not recommended for patients with severe renal impairment.
Can Tenofovir Alafenamide affect fertility?
There is no strong evidence suggesting that Tenofovir Alafenamide directly affects fertility. If you have concerns about fertility, consult your doctor for personalized advice.
Is Tenofovir Alafenamide available over-the-counter or with a prescription?
Tenofovir Alafenamide is available only with a prescription. You need to see a doctor to obtain this medication and to receive appropriate dosing instructions.
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