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Tegaserod

Uses of Tegaserod

  • The primary use of Tegaserod is to manage irritable bowel syndrome with constipation (IBS-C) in women under 65 years of age. It falls under the category of gastrointestinal agents.

  • Tegaserod is also used to manage chronic constipation of unknown cause in women under 55 years of age.

Side effects of Tegaserod

  • Diarrhoea

  • Headache

  • Abdominal pain

  • Nausea

  • Flatulence

  • Dizziness

How Tegaserod works

  • Tegaserod is a serotonin type 4 (5-HT4) receptor agonist.

  • It works by stimulating the 5-HT4 receptors present in the gastrointestinal tract. These receptors, when activated, enhance the movement of stool through the bowels. This improvement in bowel motility helps to relieve symptoms such as constipation, bloating, and abdominal discomfort associated with irritable bowel syndrome with constipation (IBS-C).

  • Additionally, Tegaserod also decreases sensitivity to abdominal pain and discomfort by inhibiting the transmission of pain signals in the intestines. Hence, this medication not only aids in stool passage but also reduces the pain and discomfort typically experienced by individuals with IBS-C.

Certified content

Written By

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Dr. Osama AhmedDental/Medical Writer, Editor, Reviewer| 2 years

Bachelor of Dental Surgery

Reviewed By

Ashmita Borgohain
Ashmita BorgohainMedical Content Writer & Editor| 12 years

MSc (Applied Genetics)

Expert Advice

Dosage Forms Available

  • Tegaserod can be taken orally (tablets).

Age and Dose Restrictions

  • This medicine is predominantly meant for adult women under the age of 65 years.

Contraindications

  • This medicine is contraindicated in patients with a history of ischemic colitis, stroke, heart attack, or transient ischemic attacks.

  • It is also contraindicated in patients with moderate or severe renal impairment or end-stage renal disease.

  • Additionally, it should not be used by those with moderate or severe liver impairment.

Other Medications to Avoid

  • Tegaserod may interact with CYP3A4 inhibitors (such as ketoconazole and clarithromycin), CYP3A4 inducers (like rifampin and carbamazepine), certain cardiac medications (like digoxin) and oral contraceptives.

Overdose and Missed Dose

  • An overdose of Tegaserod may result in symptoms like diarrhoea, headache, dizziness, and flushing. If you suspect an overdose, immediately consult your doctor.

  • If you miss a dose of this medicine, take it as soon as you remember. But if it's nearly time for your next dose, skip the missed dose and continue with your regular dosing schedule.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

  • In case of diarrhoea, ensure to stay hydrated by drinking plenty of water.

  • If you experience a headache or dizziness, rest and avoid sudden movements.

Use in Driving and Operating Machinery

  • Tegaserod may cause dizziness. Therefore, it is advised to avoid driving or operating heavy machinery until you know how this medicine affects you.

Use in Pregnancy and Lactation

  • It is not known whether Tegaserod is safe for use during pregnancy or breastfeeding. Therefore, it is advisable to consult your doctor before taking this medicine if you are pregnant or breastfeeding.

Caution in Other Conditions

  • Patients with a history of cardiovascular issues or bowel obstruction, kidney or liver disease should exercise caution when using Tegaserod.

Special Dietary and Lifestyle Recommendations

  • Incorporating a diet high in fibre can help manage the symptoms of irritable bowel syndrome.

  • Regular light exercises like walking or yoga may be beneficial.

  • It's also advisable to maintain a regular eating schedule and avoid skipping meals to help regulate bowel function.

Frequently asked questions

No, Tegaserod is not a steroid. It falls under the class of medications known as selective serotonin type 4 receptor agonists.

There is no mention of Tegaserod causing sleep disturbances in the provided references. However, if you experience any adverse effects such as sleep problems while taking this medicine, consult your doctor.

If you are planning to conceive or are concerned about fertility, discuss this with your doctor.

Tegaserod requires a prescription from a doctor and is not available over the counter.

Tegaserod should be taken as prescribed by your doctor. The dosage will depend on your personal medical condition.

Tegaserod may start to show its effect within a few days of treatment, but the full effect can take up to 4-6 weeks.

The ideal time to take Tegaserod will be recommended by your doctor. It is usually taken 30 minutes before meals.

Terms & Conditions

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