Tamoxifen
Uses of Tamoxifen
The primary use of Tamoxifen is in the management of hormone-receptor-positive breast cancer in both women and men. It belongs to the group of medicines known as selective estrogen receptor modulators (SERMs).
Secondary uses of Tamoxifen include the reduction of risk of invasive breast cancer in high-risk women, adjuvant treatment after primary therapy like surgery to decrease recurrence, treatment of ductal carcinoma in situ (DCIS), and stimulation of ovulation in some premenopausal women.
Side effects of Tamoxifen
Hot flashes
Vaginal discharge or bleeding
Menstrual irregularities
Nausea and vomiting
Skin rash
How Tamoxifen works
Tamoxifen is a selective oestrogen receptor modulator (SERM).
As an anti-oestrogen, Tamoxifen competes with oestrogen to bind to oestrogen receptors in the cells of the breast. In simple terms, it acts like a key fitting into a lock, blocking the real key, which is oestrogen, from getting in. By doing this, it helps to stop oestrogen from sending messages to these cells to grow and multiply. However, in other tissues, like the uterus, it behaves more like oestrogen itself, which can lead to some side effects.
Once inside the body, Tamoxifen is broken down by the liver into active substances called metabolites, which also help to block oestrogen's effect on breast cells. It stays in the body for quite a long time, with a half-life of 5-7 days. This means that after 5-7 days, around half of the Tamoxifen will have left your body.
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Written By
Bachelor of Dental Surgery
Reviewed By
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Expert Advice
Dosage Forms Available
- Tamoxifen is available in the form of tablets for oral administration.
Age and Dose Restrictions
- This medicine is meant for both adult men and women.
- It is also suitable for pre-and post-menopausal women.
- Always consult your doctor before taking this medication and follow the dosage prescribed by them.
Contraindications
- This medication is contraindicated in patients with known hypersensitivity to Tamoxifen or any of its components.
- It is also contraindicated in patients with a history of deep vein thrombosis or pulmonary embolism.
Other Medications to Avoid
- This medication can interact with inhibitors and inducers of CYP2D6 and CYP3A4 enzymes (such as fluoxetine, paroxetine, quinidine, and ritonavir), concurrent chemotherapy agents, and anticoagulants (such as warfarin).
- It's crucial to consult a doctor before starting any prescription medications while on Tamoxifen therapy.
Overdose and Missed Dose
- An overdose of Tamoxifen may cause symptoms like shaking, unsteady walking, dizziness, seizures, or difficulty breathing. If you observe any of these symptoms, immediately seek medical help.
- If you forget a dose, take it as soon as you remember it. However, if it is almost time for your next dose, skip the forgotten one. Do not double your dose to make up for the missed one.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
- For common side effects like hot flashes, try to stay cool and avoid triggers like spicy foods or alcohol.
- If you experience nausea, try taking the medicine after meals.
Use in Driving and Operating Machinery
- Tamoxifen can cause side effects like dizziness and blurred vision that may affect your ability to drive or operate machinery. Avoid these activities if you experience such symptoms.
Use in Pregnancy and Lactation
- Tamoxifen is not recommended for use during pregnancy as it may cause harm to the unborn baby.
- The medicine is also not recommended during breastfeeding due to potential risks to the infant.
- Always consult your doctor before using this medicine if you are pregnant or nursing.
Caution in Other Conditions
- Patients with a history of blood clots, stroke, or atherosclerosis should take Tamoxifen with caution, as it can increase the risk of these conditions.
- Regular gynecologic exams are necessary during Tamoxifen therapy due to an increased risk of endometrial cancer.
Special Dietary and Lifestyle Recommendations
- Limit consumption of grapefruits and grapefruit juice as they may increase Tamoxifen levels in the body.
- Regular physical activity can help manage side effects like fatigue and improve overall health.
- Aim for a balanced diet rich in fruits, vegetables, lean proteins, and whole grains to maintain a healthy weight and improve overall health.
- Avoid smoking and limit alcohol consumption as they can increase the risk of breast cancer.
Frequently asked questions
Can I take Tamoxifen at any time of the day?
Yes, you can take it at any time that suits you best but tries to take it at the same time every day to help you remember.
Can I take Tamoxifen with food?
Yes, you can take Tamoxifen with or without food.
Can I stop taking Tamoxifen if I feel better?
No, you should not stop taking Tamoxifen without consulting your doctor, even if you feel better. Stopping suddenly may lead to a recurrence of your symptoms or condition.
Does Tamoxifen affect fertility?
Tamoxifen may interfere with your menstrual cycle, which could affect your fertility. However, this effect is usually temporary and your periods should return to normal after stopping treatment.
Can Tamoxifen cause weight gain?
Yes, weight gain can be a side effect of Tamoxifen. If you notice significant weight changes, consult your doctor.
Does Tamoxifen cause hair loss?
Hair thinning or hair loss can be side effects of Tamoxifen. However, this is usually temporary and your hair should grow back after stopping the medicine.
Can Tamoxifen cause mood swings?
Yes, some people taking Tamoxifen have reported mood swings and changes in their mood.
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