Spironolactone
Uses of Spironolactone
- Spironolactone is a diuretic that treats high blood pressure and heart failure, and it can also reduce swelling related to heart, kidney, or liver disease.
- It is mainly used to manage conditions like high blood pressure, heart failure, hyperaldosteronism, and edema, and belongs to a category of medicines known as potassium-sparing diuretics.
- Additionally, it is utilized for the diagnosis and management of Conn's syndrome—an adrenal gland disorder causing hypertension—and is often used as part of add-on therapy to help lower blood pressure.
Side effects of Spironolactone
Upset stomach
Vomiting
Diarrhoea
Dizziness
Drowsiness
How Spironolactone works
Spironolactone is a potassium-sparing diuretic.
It operates by inhibiting the effects of the hormone aldosterone, which typically regulates water and salt balance in our bodies. Normally, aldosterone acts on the kidneys to promote the absorption of sodium and water while enhancing the excretion of potassium.
Certified content
Written By
BDS, MDS
Reviewed By
Bachelor of Dental Surgery
Expert Advice
Dosage Forms Available
Spironolactone can be taken orally (tablets and oral suspensions).
Age and Dose Restrictions
Spironolactone is intended for use by adults and children who are older than 3 years.
Contraindications
This medicine is contraindicated for patients who have Addison's disease.
It is also not advised for those with severe kidney disease or high levels of potassium in their blood.
Other Medications to Avoid
Spironolactone may interact with nonsteroidal anti-inflammatory medicines (such as ibuprofen), cardiac glycosides (like digoxin), bile acid sequestrants (like cholestyramine) and salicylates (like aspirin).
Overdose and Missed Dose
An overdose of Spironolactone can lead to severe health issues such as hyperkalemia (high potassium levels), dehydration, drowsiness and confusion. Seek immediate medical attention if you suspect an overdose.
If you miss a dose of this medicine, take it as soon as you remember. However, if it is nearly time for your next dose, skip the missed dose - do not double up on doses.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
Drinking plenty of water can help manage side effects like dizziness and headaches.
Resting or lying down can often help with feelings of drowsiness or fatigue.
Use in Driving and Operating Machinery
Spironolactone may cause dizziness or drowsiness, which could affect your ability to drive or operate machinery. It is advised to avoid these activities until you know how the medication affects you.
Use in Pregnancy and Lactation
It is generally not recommended to use Spironolactone during pregnancy unless advised by your doctor.
Though this medicine may pass into breast milk, it is unlikely to harm a nursing infant. Always consult your doctor before using this medicine while breastfeeding.
Caution in Other Conditions
Patients with kidney or liver impairment should be cautious when taking Spironolactone and always consult their doctor for advice.
Special Dietary and Lifestyle Recommendations
Avoid using potassium supplements or salt substitutes containing potassium without consulting your doctor, as Spironolactone can increase potassium levels in the body.
Frequently asked questions
Is Spironolactone a steroid?
Yes, Spironolactone is a steroid. It falls in the category of medicines known as aldosterone antagonists.
How long does it take for Spironolactone to start working?
The onset of action for Spironolactone is usually around 2-3 days, but full effects may need a few weeks to manifest. However, this can vary depending on the individual and the condition being managed.
Can Spironolactone be used for acne or excessive hair growth in women?
Yes, Spironolactone has anti-androgen properties and is sometimes used off-label to manage hormonally-driven conditions such as acne and hirsutism (excessive hair growth) in women.
Can I stop taking Spironolactone suddenly?
No, it is not advised to stop taking Spironolactone abruptly without consulting your doctor as this might worsen your condition. Your doctor will guide you on how to safely taper off the medication if needed.
Is Spironolactone vegetarian or vegan-friendly?
Spironolactone itself does not contain any animal-derived products. However, some formulations may contain inactive ingredients derived from animal sources. It is best to check with your pharmacist or read the product label carefully.
Can Spironolactone enhance athletic performance?
No, Spironolactone does not enhance athletic performance. In fact, its diuretic properties may lead to dehydration and electrolyte imbalances, which can hinder athletic performance.
Is Spironolactone addictive?
No, Spironolactone is not known to be addictive. It is a prescription medication used to manage certain medical conditions and should always be used as directed by your doctor.
Spironolactone in other salts
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