Ruxolitinib
Uses of Ruxolitinib
The primary use of Ruxolitinib is for managing certain types of bone marrow disorders like myelofibrosis and polycythemia vera. This medication belongs to a class of medicines known as kinase inhibitors.
Ruxolitinib is also effective in controlling the overproduction of blood cells in these disorders, which can lead to an enlarged spleen and other complications.
Side effects of Ruxolitinib
Anemia (low red blood cell count)
Thrombocytopenia (low platelet count)
Neutropenia (low white blood cell count)
Dizziness and headaches
Gastrointestinal disturbances
How Ruxolitinib works
Ruxolitinib is a type of medicine known as a kinase inhibitor.
It operates by selectively obstructing the action of certain enzymes called Janus Associated Kinases (JAK) 1 and 2. These enzymes play an important role in signalling pathways that manage the production of blood cells. By blocking JAK1 and JAK2, Ruxolitinib helps control the abnormal multiplication of blood cells in conditions like myelofibrosis and polycythemia vera. Therefore, it manages the symptoms associated with these conditions by reducing the overproduction of blood cells.
Certified content
Written By
BDS, MDS
Reviewed By
BMS, FMC, MD Resident
Expert Advice
Dosage Forms Available
Ruxolitinib is available for oral administration in the form of tablets.
Age and Dose Restrictions
Ruxolitinib is primarily intended for adult use. It is recommended for individuals who are at least 18 years of age.
Contraindications
Ruxolitinib is contraindicated in patients with known hypersensitivity to the medicine or any of its components.
Patients with severe liver problems should avoid the use of Ruxolitinib.
Other Medications to Avoid
Ruxolitinib can interact with strong antifungals (such as ketoconazole, itraconazole) and antibiotics (such as rifampin).
Before starting any prescription or over-the-counter medications, it is crucial to consult a doctor.
Overdose and Missed Dose
An overdose of Ruxolitinib may result in severe side effects like anaemia, thrombocytopenia, and neutropenia. If you suspect an overdose, contact your doctor immediately.
If you miss a dose of Ruxolitinib, take it as soon as you remember. However, do not double the dose if it is near the time for your next scheduled dose.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
Drinking plenty of fluids can help manage side effects like dry mouth or constipation.
Resting or getting enough sleep might help if you experience fatigue or weakness.
Use in Driving and Operating Machinery
Ruxolitinib may cause dizziness in some individuals. Therefore, if you feel dizzy after taking this medication, avoid driving or operating heavy machinery.
Use in Pregnancy and Lactation
The safety of Ruxolitinib during pregnancy and breastfeeding has not been established. It is advised to consult a doctor before using this medication during these periods.
Caution in Other Conditions
Patients with liver or kidney conditions should exercise caution when taking Ruxolitinib. Regular monitoring of liver function tests is recommended for such patients.
Special Dietary and Lifestyle Recommendations
Maintaining a balanced diet can help manage the underlying condition for which Ruxolitinib is prescribed.
Adequate rest and hydration are essential while on this medication.
Smoking and alcohol consumption should be avoided as they might worsen the condition or interfere with the effectiveness of the medication.
Frequently asked questions
How quickly does Ruxolitinib start working in the body?
The onset of action for Ruxolitinib can vary between individuals. However, it is generally observed that peak plasma concentrations of the medication are achieved within 1 to 2 hours post oral administration.
Can Ruxolitinib be taken for a longer duration?
Ruxolitinib is a prescription medicine and its duration of use should be determined by your doctor. It is essential to not self-medicate or alter the dosage without medical advice.
Is Ruxolitinib safe for people with liver or kidney problems?
Ruxolitinib should be used with caution in patients with liver or kidney impairment. It is necessary to discuss your medical history with your doctor before starting the medication.
Does Ruxolitinib affect mood or behaviour?
There is no specific information suggesting that Ruxolitinib impacts mood or behaviour. However, if you experience any changes in mood or behaviour while taking this medicine, consult your doctor immediately.
Does Ruxolitinib interact with food items?
There are no known specific interactions between Ruxolitinib and food items. However, it is always advisable to discuss your diet and lifestyle with your doctor before starting any new medication.
Can Ruxolitinib cause dependency or withdrawal symptoms?
There is no evidence to suggest that Ruxolitinib causes dependency or withdrawal symptoms. It's important to follow your doctor's instructions when starting or stopping any medication.
What medical tests are required while taking Ruxolitinib?
While taking Ruxolitinib, regular blood cell count monitoring is recommended, particularly for thrombocytopenia and neutropenia. Liver function tests should also be performed periodically.
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