Rituximab
Uses of Rituximab
The primary use of Rituximab falls in the realm of managing various autoimmune disorders and types of cancer owing to its classification as a monoclonal antibody medication.
It finds applications in treating Non-Hodgkin's Lymphoma (NHL), Chronic Lymphocytic Leukaemia (CLL), Rheumatoid Arthritis (RA), Granulomatosis with Polyangiitis (GPA), Microscopic Polyangiitis (MPA), and Pemphigus Vulgaris (PV).
Side effects of Rituximab
Headache
Fever
Chills
Nausea
Skin Rashes
How Rituximab works
Rituximab is a cancer medication.
It is a monoclonal antibody medicine that works by specifically binding to a protein known as CD20, which is found on the surface of immune system cells called B-cells. Once it attaches itself to the CD20 protein, it sets off certain processes that lead to the destruction of these B-cells. These include. Calling other immune cells to attack and eliminate the B-cells, is a process called Antibody-dependent cellular cytotoxicity (ADCC). Activating a part of the immune system called the complement system, causes the rupture of the B-cell membrane.
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Expert Advice
Dosage Forms Available
Rituximab can be administered intravenously (infusion).
Age and Dose Restrictions
Rituximab is meant for adult patients.
Contraindications
This medicine is contraindicated in patients with known severe allergic reactions to Rituximab or any of its components.
Other Medications to Avoid
Rituximab may interact with immunosuppressive medicines (such as cyclosporine and azathioprine) and liver enzyme inhibitors (such as erythromycin).
Overdose and Missed Dose
Overdosing on Rituximab may cause severe infusion reactions like difficulty breathing and chest pain. If you observe these symptoms, inform your doctor immediately.
If you miss a scheduled dose of this medication, reschedule with your healthcare provider as soon as possible.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
Drinking plenty of water can help manage mild side effects like nausea.
Taking medicine with meals can help manage gastrointestinal disturbances.
Use in Driving and Operating Machinery
Rituximab does not usually impair your ability to drive or operate heavy machinery. But, if you feel dizzy or unsteady after an infusion, avoid such activities until these symptoms subside.
Use in Pregnancy and Lactation
This medicine is not recommended during pregnancy and breastfeeding unless recommended by your doctor. Consult your doctor before using this medicine during pregnancy and breastfeeding.
Caution in Other Conditions
Patients with heart problems, kidney disease, and severe infections should exercise caution when taking this medicine.
Rituximab may reactivate the hepatitis B virus in carriers, so it should be used with caution in patients with a history of hepatitis B.
Special Dietary and Lifestyle Recommendations
Regular check-ups can help monitor the effect of Rituximab on your condition and adjust the dosage if necessary.
Avoid close contact with people who have infections as this medication may weaken the immune system and increase susceptibility to infections.
Frequently asked questions
Is Rituximab a cure for cancer?
No, it is not a cure for cancer. It is a medication used to manage conditions such as non-Hodgkin's Lymphoma and Chronic Lymphocytic Leukaemia, but it does not cure these diseases.
Does Rituximab have any effect on the immune system?
Yes, this medicine targets specific cells in the immune system known as B-cells. By destroying these cells, it can help control certain autoimmune disorders and cancers.
Can Rituximab cause weight gain?
No, it is not directly associated with causing weight gain. However, if you notice any significant changes in your weight while using this medicine, you should consult your doctor.
Does Rituximab affect mood or behaviour?
This medicine is not directly associated with affecting mood or behaviour. However, experiencing a serious illness can have an impact on your emotional well-being. Always discuss any concerns with your doctor.
Is Rituximab safe for children?
It should only be given to children if prescribed by a doctor.
Can I exercise while taking Rituximab?
There are no specific restrictions regarding exercise while taking this medicine. However, as some people may experience fatigue or weakness as a side effect of the medicine, it is advisable to speak with your doctor before starting any new exercise regimen.
Can I consume alcohol while taking Rituximab?
You should consult your doctor for advice if you consume alcohol while taking this medicine.
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