Reboxetine
Uses of Reboxetine
Reboxetine is primarily used to manage unipolar depression and belongs to the group of selective NRIs.
Side effects of Reboxetine
Dry mouth
Constipation
Headache
Nausea and vomiting
Fatigue
How Reboxetine works
Reboxetine is a selective norepinephrine reuptake inhibitor (NRI).
It operates by halting the reabsorption of the neurotransmitter norepinephrine, also known as noradrenaline, into the brain's neurones. By doing so, it increases the availability of norepinephrine in the gaps between neurones, enhancing the process of sending signals from one neurone to another through these neurotransmitters.
The heightened levels of norepinephrine are believed to positively influence mood and mitigate symptoms of depression.
Unlike certain other antidepressants, Reboxetine does not significantly affect serotonin levels.
Certified content
Written By
BDS, MDS
Reviewed By
BMS, FMC, MD Resident
Expert Advice
Dosage Forms Available
Reboxetine is available for oral use in the form of tablets.
Age and Dose Restrictions
This medicine is meant for use by adults only.
Contraindications
Reboxetine is contraindicated in patients with hypersensitivity to the active substance or any of the excipients.
It should not be used by individuals who have taken monoamine oxidase inhibitors (MAOIs) within the past two weeks.
Individuals with severe cardiovascular diseases, uncontrolled narrow-angle glaucoma, or those who have recently had a heart attack should avoid using this medication.
Other Medications to Avoid
Reboxetine may interact with MAOIs (such as phenelzine and tranylcypromine), other NRIs and serotonin-NRIs (SNRIs; such as duloxetine and venlafaxine), and tricyclic antidepressants (TCAs; such as amitriptyline and clomipramine). It can also interact with triptans (such as sumatriptan), serotonergic drugs (like SSRIs including fluoxetine and sertraline), cytochrome P450 3A4 inhibitors (such as ketoconazole), cytochrome P450 3A4 inducers (such as carbamazepine), and antihypertensives (like clonidine).
Overdose and Missed Dose
An overdose may lead to symptoms like increased heart rate, agitation, and potentially severe effects like seizures. If overdose is suspected, immediate medical advice should be sought.
If you miss a dose, take it as soon as you remember, unless it is close to the time for your next dose. Do not double the dose to catch up.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
To manage dry mouth, sip water regularly or chew sugar-free gum.
For constipation, consider increasing your intake of fibre.
If experiencing insomnia, try taking your dose earlier in the day.
In case of dizziness, move slowly from sitting to standing positions.
Use in Driving and Operating Machinery
This medicine may impair your ability to drive or operate heavy machinery. If you experience dizziness or sedation, you should avoid such activities.
Use in Pregnancy and Lactation
The safety of Reboxetine during pregnancy or breastfeeding has not been fully established. Consult your doctor before using this medicine if you are pregnant or breastfeeding.
Caution in Other Conditions
Patients with severe renal or hepatic impairment should use this medication under close medical supervision.
Patients with a history of urinary retention or seizures should use this medicine cautiously.
Special Dietary and Lifestyle Recommendations
Regular physical activity can help improve mood and energy levels. Aim for at least 30 minutes of moderate exercise most days of the week.
Establishing a regular sleep schedule can help improve mood and energy levels.
Avoid consumption of alcohol as it can interfere with the effectiveness of this medicine and worsen depression symptoms.
Frequently asked questions
Can Reboxetine affect my weight?
This medication can potentially affect your weight. Some patients might experience weight loss due to the medication's effect on appetite and metabolism. However, everyone's body reacts differently to medications; so, it is important to monitor your weight during your treatment and report any significant changes to your doctor.
Does Reboxetine interact with vitamins or supplements?
Certain vitamins and supplements may interact with this medicine, altering its effectiveness or causing side effects. For instance, St. John’s wort, a commonly used herbal supplement for depression, can increase the risk of serotonin syndrome when taken with Reboxetine. Always inform your doctor about all the vitamins and supplements you are taking.
Is there a specific time of day to take Reboxetine?
This medicine should be taken as prescribed by your doctor.
What should I do if I'm feeling more depressed or having suicidal thoughts after starting Reboxetine?
If you're feeling more depressed or having suicidal thoughts after starting Reboxetine, seek immediate medical attention. These could be signs of worsening depression or other mental health conditions, which require prompt treatment.
Can I become addicted to Reboxetine?
This medicine is not known to be addictive. However, abruptly stopping the medication can lead to withdrawal symptoms. So, it is crucial that discontinuation is done gradually under medical supervision.
Can I drink coffee or tea while taking Reboxetine?
There are no specific indications against drinking coffee or tea while taking this medicine. However, both drinks contain caffeine, which can stimulate the nervous system and may increase side effects like insomnia, nervousness, or rapid heartbeat. Discuss this with your doctor.
Can Reboxetine affect fertility?
This medicine does not interact with male or female fertility.
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