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Raloxifene

Uses of Raloxifene

  • Raloxifene is primarily used for the prevention and treatment of osteoporosis in postmenopausal women. It belongs to the class of selective oestrogen receptor modulators (SERMs).

  • It also reduces the risk of invasive breast cancer in postmenopausal women who are either diagnosed with osteoporosis or are at high risk of invasive breast cancer.

Side effects of Raloxifene

  • Hot flashes

  • Leg cramps

  • Flu-like symptoms

  • Joint pain

  • Swelling in legs/ankles/feet

How Raloxifene works

  • Raloxifene is a Selective Oestrogen Receptor Modulator (SERM).

  • It selectively activates or blocks oestrogen receptors in different tissues. In bone tissue, raloxifene acts as an oestrogen agonist, helping to maintain bone density and reduce the risk of fractures. Conversely, in breast and uterine tissues, it acts as an oestrogen antagonist, reducing the risk of oestrogen-dependent cancers.

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Written By

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Dr Nikita LoboMedical Editor & Reviewer| 7 years

BDS, MDS

Reviewed By

Dr. Chhavi Rosha
Dr. Chhavi Rosha Health & Medical Content Writer| 8 years

BMS, FMC, MD Resident

Expert Advice

Dosage Forms Available

  • Raloxifene can be taken orally (tablet).

Age and Dose Restrictions

  • This medicine is meant for adults and, specifically, postmenopausal women.

Contraindications

  • Raloxifene is contraindicated in people with a history or current diagnosis of venous thromboembolism, which includes deep vein thrombosis, pulmonary embolism, and retinal vein thrombosis. It is also contraindicated in people with known hypersensitivity to Raloxifene or any of its components.

Other Medications to Avoid

  • Raloxifene can interact with bile acid sequestrants (such as cholestyramine and colestipol), antibiotics (such as ampicillin and amoxicillin) and highly protein-bound medications (like warfarin and diazepam).

Overdose and Missed Dose

  • If an overdose of Raloxifene is suspected, seek immediate medical attention. Overdose may cause symptoms such as leg cramps, dizziness, vomiting, rash, and swelling of legs/ankles/feet.

  • If you miss a dose of Raloxifene, take it as soon as you remember. However, if it is close to the time of your next dose, skip the missed dose and continue with your regular dosing schedule.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

  • Drinking plenty of water may help reduce the occurrence of hot flashes.

  • Resting and elevating the legs can help manage peripheral oedema (swelling in legs/ankles/feet).

Use in Driving and Operating Machinery

  • Raloxifene does not generally affect the ability to drive or operate machinery. However, if you feel dizzy or lightheaded after taking it, refrain from driving or operating heavy machinery until these symptoms subside.

Use in Pregnancy and Lactation

  • Raloxifene is not recommended for use during pregnancy or lactation as it may harm a developing foetus or nursing infant. Always consult your doctor if you are pregnant, planning to become pregnant, or breastfeeding.

Caution in Other Conditions

  • Caution should be exercised when using Raloxifene in patients with a history of stroke or transient ischemic attack (TIA), atrial fibrillation, cardiovascular disease, uncontrolled hypertension, renal impairment, and hepatic impairment.

Special Dietary and Lifestyle Recommendations

  • Regular check-ups with your doctor are advised for monitoring your condition while on medication.

Frequently asked questions

Raloxifene is not known to impact your mood. However, if you experience any significant mood changes while taking Raloxifene, you should consult your doctor.

No, Raloxifene is not a steroid. It is a medicine that belongs to a class of medicines known as selective oestrogen receptor modulators (SERMs).

Raloxifene is not known to impact your sleep. However, some side effects, like hot flashes, may indirectly affect sleep. If you are experiencing sleep disturbances after starting Raloxifene, consult with your doctor.

Raloxifene is not known to affect fertility, as it is primarily used to treat and prevent osteoporosis and reduce the risk of breast cancer rather than impacting reproductive function.

Yes, it is safe to take Raloxifene daily as recommended by your doctor.

In the case of osteoporosis, anti-fracture effectiveness can be seen within 1 year of starting Raloxifene therapy, but peak increases in bone density may take around 3 years.

Raloxifene can be taken at any time during the day with or without food, as per your doctor's instructions.

Terms & Conditions

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