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Promethazine

Uses of Promethazine

  • The primary use of Promethazine is to manage symptoms of allergies such as itching, runny nose, watery eyes and sneezing. It falls under the class of first-generation antihistamines.
  • Additionally, it is utilised to prevent and control motion sickness, nausea and vomiting. It can also be used short-term for treating insomnia and to cause sedation before or after surgeries.

Side effects of Promethazine

  • Drowsiness and Sedation
  • Dry Mouth
  • Dizziness
  • Constipation
  • Blurred Vision

How Promethazine works

  • Promethazine is a first-generation antihistamine and a phenothiazine derivative.
  • The main way it works is by acting as an antagonist to histamine-1 (H1) receptors. In simpler terms, it obstructs the effects of histamine, a chemical produced by the body during allergic reactions. This mechanism reduces the ordinary allergic response like itching and inflammation.

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Written By

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Dr Nikita LoboMedical Editor & Reviewer| 7 years

BDS, MDS

Reviewed By

Dr. Osama Ahmed
Dr. Osama Ahmed Dental/Medical Writer, Editor, Reviewer| 2 years

Bachelor of Dental Surgery

Expert Advice

Dosage Forms Available

  • Promethazine can be taken orally(tablets or syrup), intravenously and intramuscularly (injection).

Age and Dose Restrictions

  • Promethazine is recommended for use in adults and children aged over 2 years.

Contraindications

  • Promethazine is contraindicated in individuals with known hypersensitivity to Promethazine or other phenothiazines.
  • It is also contraindicated in patients who are comatose or have severe central nervous system depression.

Other Medications to Avoid

  • Promethazine may interact with sedatives (such as benzodiazepines and barbiturates), opioids (like morphine and codeine), anticholinergics (for example, atropine and benztropine), and certain antipsychotics (like haloperidol, chlorpromazine).

Overdose and Missed Dose

  • In case of an overdose of Promethazine, one might experience symptoms such as severe drowsiness, seizures, abnormal heart rhythms, and respiratory failure. If you suspect an overdose, seek immediate medical attention.
  • If you miss a dose of this medicine, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve after discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor. Here are some tips to manage common side effects:

  • For dry mouth, sip on water or suck on ice chips.
  • If you experience drowsiness or dizziness, avoid activities that require mental alertness, such as driving.
  • If you get constipated, increase your fibre intake and drink plenty of fluids.

Use in Driving and Operating Machinery

  • This medicine may cause drowsiness or impair your thinking or reactions. Therefore, avoid driving or operating heavy machinery until you know how Promethazine affects you.

Use in Pregnancy and Lactation

  • Promethazine should be used during pregnancy only if the potential benefits to the mother outweigh the potential risks to the fetus. This medicine can pass into breast milk. Consult your doctor before breastfeeding while taking this medicine.

Caution in Other Conditions

  • Patients with liver disease or a history of seizures need to be cautious while using Promethazine.
  • People with cardiovascular disease or glaucoma should also use this medicine with caution as it may worsen these conditions.

Special Dietary and Lifestyle Recommendations

  • If you are taking Promethazine for allergies, avoid known allergens in your diet and environment as much as possible.
  • Maintain a regular sleep schedule if you are using it for insomnia.
  • If you are using it for motion sickness, try to sit in the front seat of a car or in the middle of a boat or plane where there is less motion. Avoid reading during travel if that causes motion sickness.

Frequently asked questions

While Promethazine may potentially cause an increase in appetite as a side effect, it does not directly contribute to weight gain or loss. However, any changes in weight should be reported to your doctor.

Promethazine is an antihistamine and can cause drowsiness, which may impact the mood of some individuals. If you experience any mood changes while taking this medicine, consult your doctor.

If you notice any irregularities in your cycle while taking this medicine, consult your doctor.

Promethazine may increase the sedative effects of caffeine and other stimulants. It is advisable to discuss with your doctor before consuming these substances together.

Promethazine remains effective as long as it is taken as per your doctor's advice. However, if you feel that the medicine is not working as effectively as it should, consult your doctor.

The effects of Promethazine on fertility are not well-studied. However, if you have concerns about fertility or are trying to conceive, it would be best to consult your doctor before taking this medication.

Yes, Promethazine can cause drowsiness and sedation as it has a mildly sedative effect due to the inhibition of the central nervous system. You should avoid driving or operating machinery until you know how this medicine affects you.

Terms & Conditions


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