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Progesterone

Uses of Progesterone

  • Progesterone is used for its critical role in regulating the menstrual cycle and maintaining pregnancy. It belongs to a class of hormones known as progestogens.

  • In addition to this primary use, Progesterone has several other applications. It is used in hormone replacement therapy (HRT) in combination with estrogen to alleviate menopausal symptoms and prevent endometrial hyperplasia.

Side effects of Progesterone

  • Fatigue and drowsiness

  • Headaches

  • Breast tenderness

  • Mood changes, such as irritability and depression

  • Gastrointestinal issues like nausea and bloating

  • Irregular vaginal bleeding or spotting

How Progesterone works

  • Progesterone is a female sex hormone.

  • This hormone plays a pivotal role in the female reproductive system. It works by helping to prepare the lining of the uterus (known as the endometrium) for implantation of a fertilised egg, that is, the early stage of pregnancy.

Certified content

Written By

docImg
Dr Vatsalya D GhanekarMedical Content Writer| 5 years

MD Ayurveda

Reviewed By

Dr. Chhavi Rosha
Dr. Chhavi Rosha Health & Medical Content Writer| 8 years

BMS, FMC, MD Resident

Expert Advice

Dosage Forms Available

  • Progesterone is available for use via oral route in the form of capsules.

  • It can also be administered vaginally in the form of gels, creams, and suppositories.

  • Progesterone is also available in the form of intramuscular injections.

  • Additionally, transdermal patches of Progesterone are also available for application on the skin.

Age and Dose Restrictions

  • This medicine is generally prescribed for adults.

Contraindications

  • This medicine is contraindicated in patients with known allergies to progesterone or any ingredients in the formulation.

  • It should not be used by patients with a history of breast cancer or other hormone-sensitive cancers.

  • Patients with undiagnosed abnormal vaginal bleeding should avoid this medicine.

  • It is also contraindicated for people with active liver disease or a history of liver problems.

  • Patients with a history of blood clots, stroke, or heart attack should not use this medicine.

Other Medications to Avoid

  • Progesterone can interact with anticonvulsants (such as carbamazepine and phenytoin), antibiotics (like rifampin), antifungals (like ketoconazole), and immunosuppressants (cyclosporine).

Overdose and Missed Dose

  • Overdosing on progesterone may result in symptoms such as dizziness, drowsiness, and abdominal pain. If you suspect an overdose, consult your doctor immediately.

  • If you miss a dose of progesterone, take it as soon as you remember. However, if it is close to the time for your next dose, skip the missed dose. Do not double the dose to make up for the missed one.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening symptoms, please consult your doctor.

  • For managing fatigue and drowsiness, take the medicine at bedtime or when you can rest.

  • If you experience headaches, try drinking plenty of water and resting in a quiet, dark room.

Use in Driving and Operating Machinery

  • Progesterone may cause dizziness and drowsiness. If you experience these side effects, avoid driving or operating heavy machinery.

Use in Pregnancy and Lactation

  • Progesterone is often used during pregnancy to support early pregnancy. However, consult your doctor before using this medicine.

  • Its use during lactation should be under the advice of a healthcare professional.

Caution in Other Conditions

  • Patients with liver disease should use this medicine with caution as it can impact liver function.

Special Dietary and Lifestyle Recommendations

  • A balanced diet rich in fruits, vegetables, lean proteins, and whole grains can support overall health and well-being while taking progesterone.

  • Regular gentle exercise can help manage some side effects like bloating and mood changes.

Frequently asked questions

Progesterone may cause mood changes, such as irritability and depression, in some people.

While weight gain is not listed as a common side effect, some patients may experience bloating while taking Progesterone.

Stopping any medicine abruptly can have potential side effects. Therefore, it is always recommended to consult your doctor before discontinuing any medication.

Yes, certain formulations of Progesterone medication are suitable for vegans and vegetarians. However, it is crucial to check with your doctor or pharmacist before starting any new medication.

Yes, Progesterone is used along with estrogen in hormone replacement therapy for postmenopausal women to alleviate menopausal symptoms.

Yes, Progesterone is used in combination with estrogen for hormone replacement therapy in postmenopausal women to alleviate menopausal symptoms and prevent endometrial hyperplasia.

Progesterone is a hormone rather than a narcotic or psychoactive substance, so there is no risk of dependency or addiction associated with its use.

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