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Phenobarbitone + Phenytoin

Uses of Phenobarbitone + Phenytoin

  • The main use of Phenobarbitone + Phenytoin is to control and manage certain types of seizures in people with epilepsy. It belongs to the group of anticonvulsant medicines.

  • Additionally, this combination of medications is also indicated for managing complex partial seizures, preventing and treating seizures that may occur during or after neurosurgery, and controlling seizures associated with status epilepticus.

Side effects of Phenobarbitone + Phenytoin

  • Drowsiness

  • Nausea and vomiting

  • Headache and blurred or double vision

  • Skin rash and itching

  • Restlessness and confusion

How Phenobarbitone + Phenytoin works

  • Phenobarbitone + Phenytoin is an anticonvulsant combination.

  • Phenobarbitone falls under the category of barbiturates. It enhances the effect of GABA, a brain neurotransmitter that inhibits nerve impulses. By boosting GABA's activity, Phenobarbitone makes neurons less excitable and increases the seizure threshold.

  • Phenytoin is a hydantoin anticonvulsant. It selectively blocks voltage-sensitive sodium channels in neurons and stabilises the threshold for electrical stimulation in the motor cortex during a seizure. This extends the effective refractory period and curtails repetitive firing of action potentials.

  • Together, these two components work to suppress the rapid firing of neurons in the central nervous system that instigates a seizure, effectively managing different types of seizures.

Certified content

Written By

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Dr. Michelle FrankMedical Content Writer| 8 years

Doctor of Medicine

Reviewed By

Dr. Divya Chauhan
Dr. Divya Chauhan Medical Writer & Reviewer| 6 years

BAMS, APG, PG

Expert Advice

Dosage Forms Available

  • Phenobarbitone + Phenytoin is available in the form of oral tablets for administration.

Age and Dose Restrictions

  • Phenobarbitone + Phenytoin combination is intended for use in adults and children. The starting dose for children is usually calculated based on their body weight.

Contraindications

  • Phenobarbitone + Phenytoin combination should not be used by patients with a known hypersensitivity to either phenobarbitone or phenytoin.

  • It is also contraindicated in patients with conditions such as porphyria and severe respiratory depression.

Other Medications to Avoid

  • This combination can interact with cytochrome P450 inducers (e.g., rifampin, carbamazepine) and cytochrome P450 inhibitors (e.g., cimetidine, fluoxetine), and affect the effectiveness of oral contraceptives (e.g., ethinylestradiol, norethindrone), corticosteroids (e.g., hydrocortisone), cardiac glycosides (e.g., digoxin), tetracycline antibiotics (e.g., doxycycline), oral anticoagulants (e.g., rivaroxaban), and antiarrhythmics (e.g., quinidine).

Overdose and Missed Dose

  • Overdosing on Phenobarbitone + Phenytoin could lead to symptoms such as drowsiness, dizziness, nausea, and vomiting. In case of an overdose, seek immediate medical attention.

  • If a dose is missed, take it as soon as you remember. However, do not double the dose to make up for the missed one.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening symptoms, please consult your doctor.

  • Drinking plenty of water can help manage side effects such as constipation.

  • Resting and avoiding strenuous activities can help manage fatigue and dizziness.

Use in Driving and Operating Machinery

  • Phenobarbitone + Phenytoin may cause drowsiness and affect your ability to drive or operate heavy machinery. It is advisable to avoid these activities if you feel dizzy or sleepy after taking the medicine.

Use in Pregnancy and Lactation

  • The use of Phenobarbitone + Phenytoin during pregnancy and lactation should be done under the guidance of a doctor due to potential risks to the baby.

Caution in Other Conditions

  • Caution should be exercised while using Phenobarbitone + Phenytoin in patients with renal or hepatic impairment.

  • Elderly patients should also be careful while taking this medicine due to increased sensitivity to its effects.

Special Dietary and Lifestyle Recommendations

  • It is advisable to maintain a healthy, balanced diet to support overall health while managing epilepsy.

  • Adequate sleep is recommended, as lack of sleep can trigger seizures.

  • Stress management techniques such as meditation and yoga can be beneficial in managing epilepsy.

  • Regular follow-ups with the doctor are necessary for monitoring the condition and adjusting the dosage if required.

Frequently asked questions

No, Phenobarbitone + Phenytoin is not a steroid. It is a combination of two anticonvulsant medications used to manage certain types of seizures.

Yes, it can be safe to take Phenobarbitone + Phenytoin daily as long as it is prescribed by your doctor.

The onset of action for Phenobarbitone + Phenytoin varies from person to person. Your doctor can provide more specific information based on your condition and dosage.

Phenobarbitone + Phenytoin can be taken at any time of the day, consistently, either with or without food, as advised by your doctor.

The duration of treatment with Phenobarbitone + Phenytoin is decided by your doctor based on your specific condition and response to the medication.

Phenobarbitone + Phenytoin is not available over the counter and requires a prescription from a doctor.

Yes, one of the common side effects of Phenobarbitone + Phenytoin can be drowsiness. Therefore, it may affect your sleep patterns.

Terms & Conditions


Phenobarbitone + Phenytoin in other salts

Available medicines for PHENOBARBITONE + PHENYTOIN
Garoin 50/100 MG Tablet 10
Garoin 50/100 MG Tablet 10
Abbott Healthcare Pvt. Ltd
Pack of 10 Units
₹30.71
MRP ₹37.45
18.00% OFF
Epilan 30/100 MG Tablet 50
Epilan 30/100 MG Tablet 50
Anglo-french Drugs & Industries Ltd.
Pack of 50 Units
₹129.89
MRP ₹158.40
18.00% OFF
Barbitoin 30/100 MG Tablet 100
Barbitoin 30/100 MG Tablet 100
Medopharm
Pack of 100 Units
₹282.69
MRP ₹344.75
18.00% OFF
Cobarb 30/100 MG Tablet 10
Cobarb 30/100 MG Tablet 10
Sigmund Promedica
Pack of 10 Units
₹25.76
MRP ₹31.42
18.00% OFF
Barbitoin 30/100 MG Tablet 10
Barbitoin 30/100 MG Tablet 10
Medopharm
Pack of 10 Units
₹29.52
MRP ₹36.00
18.00% OFF
Epicom 30/100 MG Tablet 100
Epicom 30/100 MG Tablet 100
Abbott India Ltd.
Pack of 100 Units
₹74.87
MRP ₹91.30
18.00% OFF
Epilan 30/100 MG Tablet 150
Epilan 30/100 MG Tablet 150
Lupin Ltd
Pack of 150 Units
₹485.22
MRP ₹591.73
18.00% OFF
Cobarb 50/100 MG Tablet 10
Cobarb 50/100 MG Tablet 10
Sigmund Promedica
Pack of 10 Units
₹28.11
MRP ₹34.28
18.00% OFF

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