Palbociclib
Uses of Palbociclib
Palbociclib is mainly used to manage hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced or metastatic breast cancer. It belongs to a class of medications known as cyclin-dependent kinase (CDK) 4/6 inhibitors.
Side effects of Palbociclib
Low white blood cell counts
Low red blood cell counts
Low blood platelet counts
How Palbociclib works
Palbociclib is a Cyclin-Dependent Kinase (CDK) 4/6 Inhibitor.
It works by interrupting the process of cell division in cancer cells. Specifically, it blocks the action of proteins known as cyclin-dependent kinases 4 and 6. These proteins are involved in cell cycle progression, which controls cell growth and division. By inhibiting their action, Palbociclib slows down the rapid cell division seen in cancer cells, thereby slowing the growth of tumours. Palbociclib has also been found to inhibit a cellular process called Rb phosphorylation, which is another critical process involved in allowing cells to progress from one stage of cell division to the next. Ultimately, through these actions, Palbociclib helps in managing the spread and progression of certain types of advanced or metastatic breast cancers.
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Expert Advice
Dosage Forms Available
Palbociclib can be taken orally (capsules and tablets).
Age and Dose Restrictions
Palbociclib is intended for use by both adult men and women aged 18 and above.
Contraindications
As per the available information, there are no medical conditions listed where the use of Palbociclib is contraindicated. However, it is always advisable to inform your doctor about your complete medical history before starting any new medication.
Other Medications to Avoid
Palbociclib may interact with strong inhibitors of the enzyme CYP3A (such as ketoconazole, itraconazole, and clarithromycin), strong inducers of CYP3A (such as rifampin, phenytoin, and carbamazepine), and substrates of the enzyme CYP3A (such as ergotamine).
Overdose and Missed Dose
There is no specific antidote known for a Palbociclib overdose. In case of an overdose, the treatment should be symptomatic (based on symptoms) and supportive (to support vital functions). Contact your doctor immediately.
If you realise that you have missed a dose of Palbociclib, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
Management of Side Effects
Most side effects of Palbociclib are temporary and generally harmless, resolving when you discontinue this medicine. However, if you experience any severe side effects or worsening of any symptoms, please consult your doctor.
Drinking plenty of water may help manage side effects like dry mouth and dehydration.
Eating small, frequent meals may help manage nausea.
Use in Driving and Operating Machinery
Palbociclib does not usually affect your ability to drive or operate machinery. However, if you feel dizzy or tired after taking this medicine, avoid these activities.
Use in Pregnancy and Lactation
Palbociclib can harm the foetus if used during pregnancy. Use effective contraception during treatment with Palbociclib and for at least 3 weeks after the last dose. Women are advised not to breastfeed during treatment with Palbociclib and for 3 weeks after the last dose.
Caution in Other Conditions
No specific precautions are needed for patients with renal (kidney) or hepatic (liver) impairment. However, always inform your doctor if you have kidney disease, liver disease, or any other serious medical conditions before starting this medication.
Special Dietary and Lifestyle Recommendations
Try to get enough rest to help manage fatigue, a potential side effect of this medicine.
Frequently asked questions
Can Palbociclib cause hair loss?
Yes, one of the common side effects of Palbociclib is hair loss, also known as alopecia. However, the extent of hair loss can vary among individuals.
Does Palbociclib impact mood swings?
Palbociclib does not have direct effects on mood swings. However, any prolonged illness may impact a person's mood. If you experience mood changes while using this medication, consult your doctor.
Can Palbociclib cause an increase in appetite?
No known effect of Palbociclib on appetite has been reported. In fact, decreased appetite is a common side effect of this medicine.
Are there any natural alternatives to Palbociclib?
There are no natural alternatives that can replace the specific action of Palbociclib. This medicine has a unique mechanism of action and is specifically used to manage certain types of advanced or metastatic breast cancer.
Is Palbociclib safe to use for a long duration?
With a doctor's supervision, Palbociclib can be safely taken for the required duration of therapy, which varies from patient to patient.
Does the effect of Palbociclib last all day?
Yes, the effect of Palbociclib lasts all day. However, the responses may vary from individual to individual.
What tests are required before starting treatment with Palbociclib?
Before starting treatment with Palbociclib, your doctor may require certain blood tests, including complete blood count and liver function tests.
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