Oxaliplatin
Uses of Oxaliplatin
Oxaliplatin is primarily used to manage advanced colorectal cancer and stage III colon cancer after complete surgical removal of the tumour. It belongs to the group of platinum-based anti-neoplastic agents.
It is also utilized as a first-line therapy in combination with 5-fluorouracil and leucovorin or as a second-line therapy in patients who have relapsed or become resistant to other treatments.
Side effects of Oxaliplatin
Nausea and vomiting
Fatigue and weakness
Mouth sores and throat pain
Altered taste sensations
Decreased appetite and weight loss
How Oxaliplatin works
Oxaliplatin is used to treat advanced colon or rectal cancer.
Oxaliplatin is a platinum-based anti-neoplastic agent, a type of chemotherapy medication.
It operates by forming reactive platinum complexes within the cancer cells. These complexes bind to and crosslink DNA strands, causing interference with the process of DNA synthesis and repair. This resultant damage to the DNA prevents the cancer cells from growing and dividing, leading to cell death.
Specifically, Oxaliplatin uses a unique 1,2-diaminocyclohexane ligand to form these adducts with the DNA. This specific ligand contributes to its effectiveness and reduced resistance compared with other platinum agents. Thus, through this process, Oxaliplatin can manage advanced colorectal cancer effectively.
Certified content
Written By
MSc (Applied Genetics)
Reviewed By
BMS, FMC, MD Resident
Expert Advice
Dosage Forms Available
Oxaliplatin is available for use via the intravenous route (infusion).
Age and Dose Restrictions
Oxaliplatin is typically recommended for adults and children (in combination with other chemotherapy medications).
Contraindications
Oxaliplatin is contraindicated in patients with known hypersensitivity to the agent or other platinum-containing compounds. It is also contraindicated in patients with severe kidney impairment.
Other Medications to Avoid
Oxaliplatin may interact with other chemotherapy medications (such as 5-FU, irinotecan, and topotecan), anticoagulants (like warfarin, heparin), aminoglycosides (such as neomycin, gentamicin), NSAIDs (such as Ibuprofen, naproxen), loop diuretics (such as furosemide, torsemide), and live vaccines (smallpox vaccine, MMR vaccine).
Overdose and Missed Dose
In case of an overdose of Oxaliplatin, may lead to serious side effects such as severe allergic reactions and kidney problems. If an overdose is suspected, urgent medical attention should be sought.
If a dose of Oxaliplatin is missed, it should be administered as soon as possible. However, if it is nearly time for the next dose, the missed dose should be skipped. Doubling up on doses should be avoided.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve after discontinuing this medicine. However, if you experience any severe side effects or worsening of any symptoms, please consult your doctor.
Drinking plenty of fluids can help manage side effects like nausea and vomiting.
Resting and avoiding strenuous activities may help to manage fatigue and weakness.
To manage numbness and tingling in the hands and feet, avoid exposure to cold temperatures.
Use in Driving and Operating Machinery
Oxaliplatin may cause side effects that can affect your ability to drive or operate machinery, such as dizziness or fatigue. Avoid these activities if you experience these side effects.
Use in Pregnancy and Lactation
Oxaliplatin is not recommended for use during pregnancy or while breastfeeding, as it may harm the baby. Always consult a doctor before using this medication during these periods.
Caution in Other Conditions
Caution should be taken when using Oxaliplatin in patients with pre-existing nerve damage, liver disease, or kidney disease.
Special Dietary and Lifestyle Recommendations
Stay well-hydrated before, during, and after Oxaliplatin infusions to help prevent kidney problems.
Practice good oral hygiene to help prevent mouth sores associated with chemotherapy.
Frequently asked questions
Is Oxaliplatin a steroid?
No, Oxaliplatin is not a steroid. It is a chemotherapy medication used mainly to manage advanced colorectal cancer.
Can Oxaliplatin cause sleep problems?
There is no specific mention of sleep problems as a side effect of Oxaliplatin in the references provided. However, it may cause fatigue and weakness, which might indirectly affect your sleep patterns.
Does Oxaliplatin affect fertility?
Yes, Oxaliplatin can potentially affect fertility as it is a potent chemotherapy medication.
Is it safe to take Oxaliplatin daily?
Oxaliplatin is usually given as a 2-hour infusion every two weeks. The frequency and duration of its administration should always be determined by your doctor.
How much time does Oxaliplatin take to work?
The time it takes for Oxaliplatin to start working can vary based on individual factors and the specific regimen being used. You should consult your doctor for this information.
What is the best time to take Oxaliplatin?
The best time to administer Oxaliplatin would be as directed by your healthcare provider, as it is an intravenous medication.
What is the duration of treatment with Oxaliplatin?
The duration of treatment with Oxaliplatin can vary based on individual patient factors and the specific regimen being used. It is important to adhere to the plan recommended by your doctor.
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