Ofloxacin + Metronidazole
ANTIBIOTICUses of Ofloxacin + Metronidazole
- Ofloxacin + Metronidazole is a combination medication used to treat a variety of bacterial and parasitic infections, including diarrhea, dysentery, pelvic inflammatory disease (PID), and bacterial vaginosis.
- Ofloxacin, a fluoroquinolone antibiotic, and Metronidazole, an antibiotic and antiprotozoal agent, provide broad-spectrum activity, making this combination effective for mixed infections caused by bacteria and amoeba.
Side effects of Ofloxacin + Metronidazole
- Low blood sugar
- Disturbance in attention
- Disorientation
- Agitation
- Nervousness
How Ofloxacin + Metronidazole works
- Ofloxacin is an antibiotic that works by inhibiting an enzyme called DNA gyrase, which is essential for bacteria to replicate their DNA. Without functional DNA gyrase, bacteria cannot reproduce and the infection is cleared.
- Metronidazole acts in several ways against bacteria and parasites. It disrupts their DNA replication and may also damage their cell membranes.
- When used together, Ofloxacin + Metronidazole provide a broader spectrum of activity by targeting both bacteria and parasites.
- Ofloxacin primarily targets bacteria, while Metronidazole tackles both bacteria and parasites.
Certified content
Written By
B. Pharm
Reviewed By
B. Pharm, MSc.
Expert Advice
Dosage Forms Available
- Ofloxacin + Metronidazole can be taken orally (suspension).
Age And Dose Restrictions
- It can be used by adults above 18 years of age.
Contraindications
- It is contraindicated in patients with a history of hypersensitivity to ofloxacin or metronidazole.
Other Medications To Avoid With This Medicine
- Avoid taking nutritional supplements, anti-inflammatory medications (theophylline, fenbufen), uricosurics (probenecid), antiarrhythmics (quinidine), antidepressants (sertraline) and anticoagulants (warfarin) with Ofloxacin + Metronidazole. These medications may alter the safety and effectiveness of Ofloxacin + Metronidazole.
Overdose And Missed Dose
- If you take an overdose of this combination by accident and experience worsening of any of the symptoms, please consult your doctor. It is advised to adhere to the prescribed dose.
- If you miss a dose of this combination, take it as soon as you remember. But, if the next dose is near, skip the missed dose and resume the regular dosing regime.
Management Of Side Effects
- The side effects resolve after the combination is discontinued. If side effects worsen or persist, consult your doctor for a possible treatment plan adjustment.
Use In Driving And Operating Machinery
- It is not recommended to drive, operate machinery, or do other activities that require mental alertness or coordination after taking this medicine.
Use In Pregnancy And Lactation
- Caution is advised in pregnant and breastfeeding women.
Caution In Other Conditions
- Caution should be taken in older patients especially with kidney dysfunction, liver impairment, heart problems, and patients on corticosteroids.
Special Dietary And Lifestyle Recommendation
- Make sure you drink plenty of water or other fluids every day.
- Exercise regularly for the best physical and mental health.
- Take a balanced diet to nourish the body and the brain.
- Maintain proper hygiene to avoid bacterial infections.
- Eat fibre-rich food like whole grains, beans, lentils, berries, broccoli, peas and bananas.
- Avoid foods rich in calcium, such as grapefruit and grapefruit juice, as they might hinder the absorption of antibiotics.
- Avoid consumption of alcohol and usage of tobacco.
- Antibiotics can alter the useful bacteria in the stomach, which can cause indigestion. Therefore, you are advised to take foods rich in probiotics, such as yoghurt/curd, kefir, sauerkraut, tempeh, kimchi, miso, kombucha, buttermilk, natto and cheese.
Frequently asked questions
1. How long is Ofloxacin + Metronidazole used?
This combination is used as long as the doctor prescribes it. The duration of the treatment depends upon the severity of the disease, the individual's condition and the patient's response towards the treatment.
2. Is Ofloxacin + Metronidazole an anti-fungal?
This combination comprises antifungal and antibacterial medications.
3. Is Ofloxacin + Metronidazole good for bacterial infections?
Yes, this combination is good for bacterial infections.
4. Does Ofloxacin + Metronidazole work immediately?
This combination takes more than 2-4 days to show the complete effect. The immediate effect of the medicine is seen within 1-2 hours. However, the response varies from one individual to another individual.
5. Can the use of Ofloxacin + Metronidazole cause diarrhoea?
Yes, the use of Ofloxacin + Metronidazole can cause diarrhoea as a side effect due to its impact on gut bacteria.
6. Is Ofloxacin + Metronidazole a very strong antibiotic?
Ofloxacin + Metronidazole is not classified as a very strong antibiotic, but it’s effective against certain infections.
7. How many days is it safe to take Ofloxacin + Metronidazole?
It is generally safe to take Ofloxacin + Metronidazole for 7-10 days, as prescribed by a doctor. The duration of use depends on the specific condition and your doctor’s recommendation.
8. Who should not use Ofloxacin + Metronidazole?
Individuals with a history of allergic reactions to quinolones or nitroimidazoles should avoid using Ofloxacin + Metronidazole. People with irregular heart rhythms or certain allergies should avoid it.
9. How long does it take for Ofloxacin + Metronidazole to get rid of infection?
It typically takes a few days to a week for Ofloxacin + Metronidazole to effectively clear an infection, depending on its severity.
Ofloxacin + Metronidazole in other salts
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