Nimesulide + Tizanidine
Uses of Nimesulide + Tizanidine
Nimesulide + Tizanidine is primarily used to manage painful muscle spasms associated with acute musculoskeletal conditions. This combination falls in the category of non-steroidal anti-inflammatory drugs (NSAIDs) and skeletal muscle relaxants.
It is also beneficial for managing symptoms related to conditions such as arthritis, lower back pain, neck pain, muscle strains, sports injuries, and post-operative pain.
Side effects of Nimesulide + Tizanidine
Abdominal pain
Nausea
Dizziness
Drowsiness
Low blood pressure
How Nimesulide + Tizanidine works
Nimesulide is a non-steroidal anti-inflammatory drug (NSAID). It works by blocking the action of a substance in the body called cyclooxygenase, responsible for making chemicals causing pain and inflammation. By reducing these chemicals, nimesulide helps relieve pain and reduce swelling.
Tizanidine is a muscle relaxant. It acts on the nervous system to calm down nerve impulses that cause muscle spasm and stiffness. By reducing these impulses, tizanidine helps to relax muscles, decreasing spasms and easing pain.
Certified content
Written By
MSc (Applied Genetics)
Reviewed By
BMS, FMC, MD Resident
Expert Advice
Dosage Forms Available
Nimesulide + Tizanidine is available for oral administration in the form of tablets.
Age and Dose Restrictions
This medicine is meant for adults and children above 12 years of age.
Contraindications
This medicine is contraindicated in patients with known hypersensitivity to nimesulide or tizanidine, and in patients with active peptic ulcer, severe liver impairment, severe kidney impairment and severe heart failure.
Other Medications to Avoid
This combination may interact with antidepressants (e.g., fluvoxamine, ciprofloxacin), oral contraceptives (e.g., norgestrel, desogestrel) CNS depressants (e.g., clonazepam, diazepam), antihypertensive agents (e.g., lisinopril, losartan) and anticoagulants (e.g., warfarin).
Overdose and Missed Dose
An overdose of this medication may cause symptoms such as drowsiness, dizziness, hypotension, bradycardia and potentially serious gastrointestinal events. If you observe these symptoms, inform your doctor immediately.
If you miss a dose of this medicine, take it as soon as you remember. However, if it's almost time for the next dose, skip the missed dose and continue with your regular schedule. Do not double up on the dose to make up for a missed one.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
Drinking plenty of water can help manage gastrointestinal side effects like nausea and abdominal pain.
Resting or lying down can help manage dizziness or fatigue.
Use in Driving and Operating Machinery
This medication may cause drowsiness or dizziness. Avoid driving or operating heavy machinery if you experience these side effects.
Use in Pregnancy and Lactation
Nimesulide + Tizanidine is not recommended for use during pregnancy or while breastfeeding. It's advised to consult your doctor before using this medicine during these periods.
Caution in Other Conditions
Patients with hepatic or renal conditions should exercise caution when taking this medicine.
Patients with cardiovascular diseases should also be careful as this medicine may cause low blood pressure or prolong the QT interval.
Special Dietary and Lifestyle Recommendations
No special dietary or lifestyle recommendations are required for this combination medicine.
Frequently asked questions
Is it safe to take Nimesulide + Tizanidine daily?
Yes, it is safe to take Nimesulide + Tizanidine daily only if prescribed by your doctor for managing painful muscle spasms from musculoskeletal conditions and injuries.
Does Nimesulide + Tizanidine make you feel sleepy?
Yes, one of the components of this combination, Tizanidine, is known to cause drowsiness and sedation. So, avoid activities requiring alertness, such as driving or operating machinery when taking this medicine.
Are there any particular diet restrictions while taking Nimesulide + Tizanidine?
There are no specific food restrictions when taking this combination medicine. However, it's generally advised to eat a balanced diet while on medication.
What is the duration of treatment with Nimesulide + Tizanidine?
The duration of treatment with Nimesulide + Tizanidine is determined by your doctor based on your condition and response.
Is the Nimesulide + Tizanidine available over the counter, or do I need a prescription?
The combination medicine generally requires a doctor's prescription, and it is not usually available over the counter.
Is Nimesulide + Tizanidine safe for long-term use?
Nimesulide + Tizanidine is generally safe for short-term use under a doctor's supervision due to the potential risk of stomach bleeding and liver problems with long-term use.
Can I stop taking Nimesulide + Tizanidine when my pain is relieved?
It is advised to complete the full course of Nimesulide + Tizanidine as prescribed by your doctor to avoid symptom recurrence, even if you feel better.
Nimesulide + Tizanidine in other salts
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