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Naltrexone

Uses of Naltrexone

  • Naltrexone is used to manage alcohol and opioid dependence. It belongs to a group of medicines known as opioid antagonists.

  • It has also been studied for potential use in managing other conditions like gambling addiction, binge eating disorder, and self-injurious behaviours in autism.

Side effects of Naltrexone

  • Nausea

  • Headache

  • Dizziness

  • Fatigue

  • Anxiety

How Naltrexone works

  • Naltrexone is an opioid receptor antagonist.

  • It works by selectively binding to opioid receptors, specifically the mu-opioid receptors, in the central nervous system. By occupying these receptors, it prevents the activation of these pathways by opioid substances, thus blocking their effects and reducing cravings for opioids.

Certified content

Written By

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Dr Nikita LoboMedical Editor & Reviewer| 7 years

BDS, MDS

Reviewed By

Dr. Chhavi Rosha
Dr. Chhavi Rosha Health & Medical Content Writer| 8 years

BMS, FMC, MD Resident

Expert Advice

Dosage Forms Available

  • Naltrexone is available as oral tablets for individuals to take by mouth.

  • It is also available as an extended-release injectable suspension, which is administered through the intramuscular route by a healthcare provider.

Age and Dose Restrictions

  • This medicine is meant for adults. It is not typically prescribed for children or adolescents.

Contraindications

  • Naltrexone is contraindicated in patients with acute opioid withdrawal.

  • It is contraindicated in those who have current opioid dependence or a positive opioid urine screen.

  • Patients with acute hepatitis or liver failure should not use this medicine.

Other Medications to Avoid

  • This medicine can interact with opioid-containing medications (such as morphine and methadone), CNS depressants (like benzodiazepines and alcohol), and any other substance that may act on the opioid receptors or enhance CNS depression.

Overdose and Missed Dose

  • An overdose of Naltrexone may result in symptoms like nausea, severe headache, or confusion. If you suspect an overdose, it is important to seek immediate medical attention from your doctor.

  • If you miss a dose of Naltrexone, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take an extra dose to make up for the missed one.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any symptoms, please consult your doctor.

  • For nausea, try taking the medicine with food unless instructed otherwise by your doctor.

  • If experiencing dizziness, ensure you rest and avoid movements that may exacerbate the condition until you feel stable.

Use in Driving and Operating Machinery

  • Naltrexone may cause dizziness or tiredness. You should avoid driving or operating heavy machinery until you know how this medication affects you.

Use in Pregnancy and Lactation

  • The use of this medicine during pregnancy or breastfeeding is not recommended without a doctor's advice. It is best to consult your doctor before taking this medication if you are pregnant or nursing.

Caution in Other Conditions

  • Individuals with liver issues need to exercise caution when using Naltrexone due to its potential impact on liver function. Regular monitoring of liver function tests is recommended.

  • Those who have recently used opioids should be aware that starting Naltrexone too soon after opioid use can cause severe withdrawal symptoms.

Special Dietary and Lifestyle Recommendations

  • For individuals managing alcohol dependence with Naltrexone, avoiding alcoholic beverages is crucial as the combination can lead to significant health issues including potential liver damage.

  • Maintaining a balanced diet that supports liver health can be beneficial. This includes consuming foods rich in antioxidants such as leafy greens, fruits, and whole grains.

  • Engaging in regular physical activity can help improve overall health and aid in the recovery process from substance dependency.

  • It is also important to engage in therapeutic activities that support mental health such as mindfulness practices, counselling sessions, and stress management techniques.

Frequently asked questions

No, Naltrexone is not an opioid. It is actually an opioid antagonist, which means that it works by blocking the effects of opioids in the brain.

Naltrexone is not typically associated with weight gain. However, everyone's body responds differently to medications, and if you notice any significant changes in weight while taking Naltrexone, you should discuss this with your doctor.

While Naltrexone is primarily prescribed for alcohol and opioid dependence, it is currently being studied for use in managing other conditions as well, such as gambling addiction and binge eating disorder.

No, you should not start taking Naltrexone until you have been free from opioids for at least 7-10 days. Starting Naltrexone too early could cause you to suddenly go into withdrawal.

While Naltrexone primarily works by affecting the way the brain responds to alcohol and opioids, it can potentially have some impact on mood as well. Some people may experience side effects such as anxiety or depression while taking this medicine.

The duration of treatment with Naltrexone can vary depending on individual needs and responses. Typically, it is prescribed for several months to a year as part of a comprehensive treatment programme.

After discontinuing Naltrexone, your body may be more sensitive to the effects of opioids. This means that if you start using opioids again, you could be at risk of an overdose.

Terms & Conditions

Available medicines for NALTREXONE
Nodict 50 MG Tablet 10
Nodict 50 MG Tablet 10
Sun Pharma Laboratories Ltd.
Pack of 10 Units
₹610.90
MRP ₹745.00
18.00% OFF
Addtrex 50 MG Tablet 10
Addtrex 50 MG Tablet 10
Rusan Healthcare Pvt. Ltd
Pack of 10 Units
₹657.56
MRP ₹801.90
18.00% OFF
Naltrawave Tablet 10
Naltrawave Tablet 10
Brainwave Healthcare Pvt Ltd
Pack of 10 Units
₹705.20
MRP ₹860.00
18.00% OFF
Opinat Tablet 10
Opinat Tablet 10
Chemo Health Care Pvt Ltd
Pack of 10 Units
₹703.56
MRP ₹858.00
18.00% OFF
Naltivia 50 Tablet 10
Naltivia 50 Tablet 10
Healing Pharma
Pack of 10 Units
₹531.02
MRP ₹875.00
39.31% OFF
Naltox 50  MG Tablet 10
Naltox 50 MG Tablet 10
Dd Pharmaceuticals Pvt. Ltd.
Pack of 10 Units
₹623.20
MRP ₹760.00
18.00% OFF
Naltivive 25 MG Tablet 10
Naltivive 25 MG Tablet 10
Gentech Healtcare Ltd
Pack of 10 Units
₹328.00
MRP ₹400.00
18.00% OFF
Naltima 50 MG Tablet 10
Naltima 50 MG Tablet 10
Intas Pharmaceuticals Ltd
Pack of 10 Units
₹628.12
MRP ₹766.00
18.00% OFF

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