N-butyl-2-cyanoacrylate
Uses of N-butyl-2-cyanoacrylate
N-Butyl-2-Cyanoacrylate is primarily used as a topical skin adhesive to close surgical incisions and lacerations. It is part of the cyanoacrylate family of medical adhesives.
It can be particularly beneficial in emergency settings for repairing lacerations, in laparoscopic surgery for closing incisions, post skin lesion removal or biopsies, and in conjunction with sutures or staples for high-tension wounds.
Side effects of N-butyl-2-cyanoacrylate
Skin irritation or inflammation at the application site
Rare allergic reactions
Wound reopening if used on wounds under high tension
Foreign body sensation as the adhesive polymerizes
How N-butyl-2-cyanoacrylate works
N-Butyl-2-Cyanoacrylate is a medical adhesive used for wound closure, tissue adhesion, and as a surgical sealant.
It works by polymerizing rapidly upon contact with moisture, forming a strong bond that holds tissues together. This adhesive is commonly used as an alternative to sutures or staples for minor cuts and surgical incisions. It is also used in various medical procedures like embolization of blood vessels.
Certified content
Written By
Doctor of Medicine
Reviewed By
BMS, FMC, MD Resident
Expert Advice
Dosage Forms Available
N-Butyl-2-Cyanoacrylate is applied topically (liquid).
Age and Dose Restrictions
N-Butyl-2-Cyanoacrylate is suitable for adults and children above the age of 2 years.
Contraindications
The use of N-Butyl-2-Cyanoacrylate is contraindicated in patients with known allergies to cyanoacrylates. It should also not be applied to infected wounds or near the eyes or inside the mouth.
Other Medications to Avoid
N-Butyl-2-Cyanoacrylate may interact with other topical adhesives (like octyl cyanoacrylate), as well as products containing alcohol or strong surfactants.
Overdose and Missed Dose
Overdose of N-Butyl-2-Cyanoacrylate is unlikely as it is intended for external use only. Using the prescribed dosage is recommended to avoid any side effects.
As a wound dressing, a missed dose situation generally does not apply to N-Butyl-2-Cyanoacrylate. If the adhesive has prematurely peeled off, consult with your doctor.
Management of Side Effects
Most side effects associated with N-Butyl-2-Cyanoacrylate are temporary and generally harmless, resolving once the adhesive naturally peels away. However, if you experience any severe side effects or worsening of symptoms, please consult your doctor.
Skin irritation can be eased by keeping the area clean and avoiding scratching.
If you feel a foreign body sensation as the adhesive polymerises, try to avoid touching or picking at the adhesive.
Use in Driving and Operating Machinery
N-Butyl-2-Cyanoacrylate is a topical medication and does not affect your ability to drive or operate machinery.
Use in Pregnancy and Lactation
As N-Butyl-2-Cyanoacrylate is applied on the skin and does not have systemic absorption, it is generally safe to use during pregnancy and lactation. However, it is always advisable to consult your doctor before using any medication during these periods.
Caution in Other Conditions
There are no specific medical conditions where caution needs to be exercised while using N-Butyl-2-Cyanoacrylate. However, it should not be applied to infected wounds or near the eyes or inside the mouth.
Special Dietary and Lifestyle Recommendations
Maintain good hygiene to support wound healing when using N-Butyl-2-Cyanoacrylate.
Avoid activities that may strain the wound site or interfere with the adhesive.
Ensure a balanced diet high in proteins, vitamins, and minerals to facilitate wound healing.
Stay well-hydrated, as dehydration can potentially slow down healing processes.
Frequently asked questions
Is N-Butyl-2-Cyanoacrylate a type of antibiotic?
No, N-Butyl-2-Cyanoacrylate is not an antibiotic. It is a type of medical adhesive used to close wounds, particularly in surgical settings.
Does N-Butyl-2-Cyanoacrylate have any effect on hormones or mood?
As N-Butyl-2-Cyanoacrylate does not get absorbed into the systemic circulation, it has no known influence on hormones or mood.
Are there any natural alternatives to N-Butyl-2-Cyanoacrylate for wound closure?
While there are natural products that facilitate wound healing, none can match the adhesive properties of N-Butyl-2-Cyanoacrylate for wound closure. Always consult a doctor before using any alternative methods for wound closure.
Does N-Butyl-2-Cyanoacrylate have any effect on sleep?
N-Butyl-2-Cyanoacrylate is not directly associated with affecting sleep. It is primarily used for wound closure and does not have systemic effects.
Will N-Butyl-2-Cyanoacrylate affect fertility?
N-Butyl-2-Cyanoacrylate is not associated with affecting fertility as this substance functions as an external adhesive for wound closure and does not have systemic absorption.
How much time does N-Butyl-2-Cyanoacrylate take to work?
N-Butyl-2-Cyanoacrylate works almost instantly. After being applied to the skin, it polymerizes within seconds to form a strong, flexible bond holding the wound edges together.
Are there any products that can weaken the bond of N-Butyl-2-Cyanoacrylate?
Yes, certain topical products like petroleum jelly can weaken the bond formed by N-Butyl-2-Cyanoacrylate and should therefore be avoided on the wound area.
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