Mycophenolate Mofetil
Uses of Mycophenolate Mofetil
Primary use of Mycophenolate Mofetil is to prevent organ rejection in patients who have received transplants such as kidney, heart, or liver. It falls under the immunosuppressant class of medications specifically known as antimetabolites.
Off-label, it is sometimes used to manage autoimmune diseases such as lupus nephritis, autoimmune hepatitis, and pemphigus vulgaris.
Side effects of Mycophenolate Mofetil
Diarrhoea
Nausea
Vomiting
Abdominal pain
Blood disorders
How Mycophenolate Mofetil works
Mycophenolate Mofetil is an immunosuppressant medicine.
It works by inhibiting an enzyme known as inosine monophosphate dehydrogenase (IMPDH). This enzyme is crucial for the growth of T and B lymphocytes, which are types of white blood cells integral to your body's immune defence. By blocking IMPDH, Mycophenolate Mofetil suppresses the proliferation of these lymphocytes. This action weakens the immune response that might otherwise lead to organ transplant rejection. As a result, Mycophenolate Mofetil helps to manage the immune system and prevent it from rejecting transplanted organs.
Certified content
Written By
BDS, MDS
Reviewed By
BMS, FMC, MD Resident
Expert Advice
Dosage Forms Available
Mycophenolate Mofetil can be taken orally (capsules, oral suspensions and tablets) and intravenously (injection).
Age and Dose Restrictions
Mycophenolate Mofetil is meant for adults.
Contraindications
Mycophenolate Mofetil is contraindicated in patients with a known hypersensitivity to the medicine or its inactive ingredients. Patients with active serious digestive system disease or severe renal impairment should avoid taking this medication.
Other Medications to Avoid
Mycophenolate Mofetil may interact with antacids (such as calcium carbonate and aluminium hydroxide), bile acid sequestrants (such as cholestyramine) antiviral medications (like acyclovir, ganciclovir and valacyclovir).
Overdose and Missed Dose
An overdose of Mycophenolate Mofetil may cause severe side effects such as gastrointestinal disturbances, blood disorders, and increased susceptibility to infections. In case of suspected overdose, consult your doctor immediately.
If you miss a dose, take it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
To manage gastrointestinal side effects such as diarrhoea and vomiting, try taking the medicine after meals.
Ensure to keep yourself well hydrated to avoid dehydration caused by diarrhoea.
Use in Driving and Operating Machinery
Mycophenolate Mofetil may cause dizziness or confusion. If you experience these side effects, avoid driving or operating heavy machinery until you feel well again.
Use in Pregnancy and Lactation
Mycophenolate Mofetil is not recommended during pregnancy or breastfeeding unless advised by your doctor. Women of childbearing potential must have a negative pregnancy test before starting therapy and use effective contraception.
Caution in Other Conditions
Patients with renal impairment or active serious digestive system disease should exercise caution when taking Mycophenolate Mofetil.
Elderly patients may be more sensitive to the medicine's adverse effects.
Special Dietary and Lifestyle Recommendations
Maintain personal hygiene to minimize the risk of infections due to suppressed immunity.
Protect your skin from the sun to reduce the risk of skin cancer, a potential side effect of this medicine.
Regular monitoring through complete blood counts is necessary to detect any blood disorders early.
Frequently asked questions
Is Mycophenolate Mofetil a steroid?
No, Mycophenolate Mofetil is not a steroid. It belongs to the class of immunosuppressive medicines known as antimetabolites, which function differently from steroids.
Can Mycophenolate Mofetil affect my mood?
Mycophenolate Mofetil is not directly associated with affecting mood. However, if you are experiencing mood changes, consult your doctor as these could be related to your overall health condition rather than the medicine.
Will Mycophenolate Mofetil interfere with my menstrual cycle?
Mycophenolate Mofetil does not typically interfere with the menstrual cycle. However, if you notice any irregularities or changes in your menstrual cycle, it might be worth discussing this with your doctor.
Does Mycophenolate Mofetil cause weight gain?
Weight gain is not typically associated with Mycophenolate Mofetil. However, if you notice unexplained weight gain while taking this medicine, consult your doctor for advice.
Is Mycophenolate Mofetil addictive?
No, Mycophenolate Mofetil is not a habit-forming medicine.
How long does It take for Mycophenolate Mofetil to start working?
The onset of action of Mycophenolate Mofetil is usually within a few days. However, the maximum immunosuppressive effect may take up to several weeks to become evident.
Will Mycophenolate Mofetil affect fertility?
Mycophenolate Mofetil may have potential effects on fertility. Women of reproductive potential must have a negative pregnancy test before starting therapy and use effective contraception. The medicine may also be present in semen, so sexually active men are advised to use condoms during and for 90 days after treatment.
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